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Tag: gene expression

Illumina: DNA giant in troubled waters  

A botched acquisition deal and unrest among company investors amid plummeting stocks have plagued Illumina, which was once part of the biotech big leagues...

Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner – Nature Communications

Acute platelet depletion rapidly recruits quiescent HSCs into proliferationIn line with previous studies9, administration of a single dose of anti-GPIbα antibody to Vwf-GFP mice,...

To Defend the Genome, These Cells Destroy Their Own DNA | Quanta Magazine

IntroductionMarie Delattre was studying the sexual reproduction practices of microscopic worms when she noticed something unexpected. Under the microscope, an embryo of the nematode...

How Cells Safeguard the Genome by Destroying Their Own DNA: Insights from Quanta Magazine

How Cells Safeguard the Genome by Destroying Their Own DNA: Insights from Quanta MagazineThe genome, the complete set of genetic material in an organism,...

Eight anti-aging startups on a mission to extend lives

The longevity biotech industry revolves around the goal of increasing the period of life that a person spends in good health. There has been...

Aberrant differentiation of epithelial progenitors is accompanied by a hypoxic microenvironment in the paraquat-injured human lung – Cell Discovery

Dear Editor,Paraquat is a toxic herbicide that can cause severe lung injury, leading to alveolar epithelial cell death, subsequent lung fibrosis and respiratory failure....

Four novel receptors may link endometrial cancer to PCOS

“These findings hold significant promise for improving our understanding of mechanistic pathways leading to EC in PCOS.” Credit: 2023 Alqutami et al. “These findings hold significant...

Base editing hits the clinic in the U.S.

Over the past couple of years, base editing, a recent offshoot of the heralded CRISPR/Cas 9 technology, has been doing its rounds in the...

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9 – Nature Communications

Ethics statementAll iPSC lines were previously derived from skin biopsy fibroblasts, following signed informed consent, collected under ethical approval granted by the South Wales...

Abnormal developmental trajectory and vulnerability to cardiac arrhythmias in tetralogy of Fallot with DiGeorge syndrome – Communications Biology

Generation and characterisation of patient-specific hiPSCs and hiPSC-CMshiPSC lines were established from two TOF-DG patients, two TOF-ND patients, and two healthy controls with pluripotency...

Long non-coding RNA SNHG8 drives stress granule formation in tauopathies – Molecular Psychiatry

Bodea LG, Eckert A, Ittner LM, Piguet O, Götz J. Tau physiology and pathomechanisms in frontotemporal lobar degeneration. J Neurochem. 2016;138:71–94.Article  CAS  PubMed  PubMed...

Defining epigenetic reprogramming, cellular reprogramming & rejuvenation – The Niche

Epigenetic reprogramming is a term used in cell biology that is increasingly ending up in news stories too. Unfortunately, some folks, especially in the cellular...

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