Barber, G. N. STING: infection, inflammation and cancer. Nat. Rev. Immunol. 15, 760–770 (2015).
Srikanth, S. et al. The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum. Nat. Immunol. 20, 152–162 (2019).
Li, S. et al. Prolonged activation of innate immune pathways by a polyvalent STING agonist. Nat. Biomed. Eng. 5, 455–466 (2021).
Corrales, L. et al. Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11, 1018–1030 (2015).
Li, L. et al. Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nat. Chem. Biol. 10, 1043–1048 (2014).
Shae, D. et al. Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy. Nat. Nanotechnol. 14, 269–278 (2019).
Kato, K. et al. Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1. Nat. Commun. 9, 1–8 (2018).
Pan, B.-S. et al. An orally available non-nucleotide STING agonist with antitumor activity. Science 369, eaba6098 (2020).
Chin, E. N. et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science 369, 993–999 (2020).
Konno, H. et al. Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production. Oncogene 37, 2037–2051 (2018).
Xia, T., Konno, H. & Barber, G. N. Recurrent loss of STING signaling in melanoma correlates with susceptibility to viral oncolysis. Cancer Res. 76, 6747–6759 (2016).
Tse, S.-W. et al. mRNA-encoded, constitutively active STINGV155M is a potent genetic adjuvant of antigen-specific CD8+ T cell response. Mol. Ther. 29, 2227–2238 (2021).
Hong, C. et al. cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers. Nature 607, 366–373 (2022).
Tu, X. et al. Interruption of post-Golgi STING trafficking activates tonic interferon signaling. Nat. Commun. 13, 6977 (2022).
Zhang, C. et al. Structural basis of STING binding with and phosphorylation by TBK1. Nature 567, 394–398 (2019).
Shang, G., Zhang, C., Chen, Z. J., Bai, X.-c & Zhang, X. Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP. Nature 567, 389–393 (2019).
Zhao, B. et al. A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature 569, 718–722 (2019).
Wang, C., Sharma, N., Kessler, P. M. & Sen, G. C. Interferon induction by STING requires its translocation to the late endosomes. Traffic 24, 576–586 (2023).
Wang, C. et al. STING-mediated interferon induction by herpes simplex virus 1 requires the protein tyrosine kinase Syk. Mbio 12, e03228–03221 (2021).
Li, C. et al. Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine. Nat. Immunol. 23, 543–555 (2022).
Stetefeld, J. et al. Crystal structure of a naturally occurring parallel right-handed coiled coil tetramer. Nat. Struct. Biol. 7, 772–776 (2000).
Wu, J., Dobbs, N., Yang, K. & Yan, N. Interferon-independent activities of mammalian STING mediate antiviral response and tumor immune evasion. Immunity 53, 115–126 (2020).
Barber, G. N. STING-dependent cytosolic DNA sensing pathways. Trends Immunol. 35, 88–93 (2014).
de Oliveira Mann, C. C. et al. Modular architecture of the STING C-terminal tail allows interferon and NF-κB signaling adaptation. Cell Rep. 27, 1165–1175. e1165 (2019).
Abe, T. & Barber, G. N. Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1. J. Virol. 88, 5328–5341 (2014).
Liu, T., Zhang, L., Joo, D. & Sun, S.-C. NF-κB signaling in inflammation. Signal Transduct. Target. Ther. 2, 1–9 (2017).
Tak, P. P. & Firestein, G. S. NF-κB: a key role in inflammatory diseases. J. Clin. Investig. 107, 7–11 (2001).
Xu, J. et al. Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer. Nat. Nanotechnol. 14, 388–397 (2019).
Hotz, C. et al. Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models. Sci. Transl. Med. 13, eabc7804 (2021).
Hewitt, S. L. et al. Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs. Sci. Transl. Med. 11, eaat9143 (2019).
Akita, H. Development of an SS-cleavable pH-activated lipid-like material (ssPalm) as a nucleic acid delivery device. Biol. Pharm. Bull. 43, 1617–1625 (2020).
Cheng, Q. et al. Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing. Nat. Nanotechnol. 15, 313–320 (2020).
Augustine, C. et al. Blood parameters of wistar albino rats fed processed tropical sickle pod (Senna obtusifolia) leaf meal-based diets. Transl. Anim. Sci. 4, 778–782 (2020).
Marcus, A. et al. Tumor-derived cGAMP triggers a STING-mediated interferon response in non-tumor cells to activate the NK cell response. Immunity 49, 754–763 (2018).
Li, W. et al. cGAS-STING–mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy. Sci. Transl. Med. 12, eaay9013 (2020).
Krishna, S. et al. Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer. Science 370, 1328–1334 (2020).
Tkach, M. & Théry, C. Communication by extracellular vesicles: where we are and where we need to go. Cell 164, 1226–1232 (2016).
Torralba, D. et al. Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts. Nat. Commun. 9, 2658 (2018).
Ishii, H. et al. miR-130a and miR-145 reprogram Gr-1+ CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity. Nat. Commun. 9, 2611 (2018).
Yang, J. et al. MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene. Oncogene 33, 3014–3023 (2014).
Ji, Y., Hocker, J. D. & Gattinoni L. in Seminars in Immunology (eds Kroemer, G. & Mantovani, A.) 45–53 (Elsevier, 2016).
Lee, S. Y. et al. Wnt/Snail signaling regulates cytochrome c oxidase and glucose metabolismregulation of mitochondria and metabolism by Wnt/Snail. Cancer Res. 72, 3607–3617 (2012).
Stemmer, V., De Craene, B., Berx, G. & Behrens, J. Snail promotes Wnt target gene expression and interacts with β-catenin. Oncogene 27, 5075–5080 (2008).
Xu, X., Zhang, M., Xu, F. & Jiang, S. Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities. Mol. Cancer 19, 35 (2020).
Tokar, T. et al. mirDIP 4.1—integrative database of human microRNA target predictions. Nucleic Acids Res. 46, D360–D370 (2018).
Hashiba A. et al. The use of design of experiments with multiple responses to determine optimal formulations for in vivo hepatic mRNA delivery. J. Control. Release 327, 467–476 (2020).
Sabnis, S. et al. A novel amino lipid series for mRNA delivery: improved endosomal escape and sustained pharmacology and safety in non-human primates. Mol. Ther. 26, 1509–1519 (2018).
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