Want to keep track of the largest startup funding deals in 2023 with our new curated list of $100 million-plus venture deals to U.S.-based companies? Check out The Crunchbase Megadeals Tracker.

Investors turned their attention to biotech and health, as more than half the big rounds this week fell into that bucket. Biotech was the big winner, getting three rounds in the top five and four all told on the list. In general, it was a pretty slow week, but that is not out of the ordinary for this time of year.

1) Septerna, $150M, biotech: Biotech leads off this week, as South San Francisco, California-based Septerna closed a $150 million Series B led by new investor RA Capital Management. Septerna focuses on small molecule drugs that target proteins called G protein-coupled receptors, which control signals across cellular membranes and are often targeted by drug developers. Septerna is one of them, and is developing a treatment for hypoparathyroidism, a condition characterized by the deficiency of parathyroid hormone — which controls blood calcium and phosphate levels. Founded just last year, the company has now raised $250 million, per Crunchbase.

2) Hyperice, $100M-plus, health: Back in 2020, wellness brand Hyperice raised a $48 million Series A from noted athletes such as NBA stars Chris Paul and Anthony Davis, which puts the firm at a $700 million valuation. Since then, the Irvine, California-based company — which sells a variety of devices to help people move and recover better — has been a little quiet on the fundraising front. However, this week it locked up a $100 million-plus investment from private equity firm Atlas Credit Partners. No new valuation was given. Hyperice said it will use the cash to grow after introducing five new products in the last year. The firm has raised nearly $148 million, per Crunchbase.

3) SpyGlass Pharma, $90M, biotech: More biotech, as Aliso Viejo, California-based SpyGlass Pharma locked up a $90 million Series C led by RA Capital Management. The ophthalmic therapeutics company has developed a system that helps deliver medical therapy to address glaucoma management as well as other chronic ophthalmic diseases when implanted at the time of cataract surgery. Founded in 2019, the firm has raised nearly $110 million, according to Crunchbase data.

4) Avnos, $80M, environmental engineering: Carbon storage and removal is big business and popular in venture right now. Los Angeles-based Avnos became one of the latest in the space to raise big cash, signing “multi-year strategic and investment partnerships” worth more than $80 million with ConocoPhillips, JetBlue Ventures and Shell Ventures. The company has developed a “hybrid direct air capture” unit for carbon dioxide removal. Avnos expects to deliver commercial-ready HDAC units by the end of 2025. This is the first disclosed round, per Crunchbase, for the company founded in 2021.

4) Crossbow Therapeutics, $80M, biotech: Are you getting the idea it was a big week for biotech and health? Cambridge, Massachusetts-based Crossbow Therapeutics joined the hit parade after raising an $80 million Series A funding round led by MPM BioImpact and Pfizer Ventures. The company is developing antibody therapies to treat a broad range of cancers. Founded in 2021, this is the company’s first announced funding, per Crunchbase.

5) Arthrosi Therapeutics, $75M, biotech: San Diego-based Arthrosi Therapeutics, a clinical-stage biotechnology company, closed a $75 million Series D led by Guangrun Health Industry. Founded in 2020, the company has raised more than $117 million, per Crunchbase.

6) Bobbie, $70M, food: San Francisco-based Bobbie, an organic infant formula company, raised a $70 million Series C led by PowerPlant Partners to acquire Nature’s One, a pediatric nutrition company. Founded in 2018, the company has raised nearly $92 million, according to Crunchbase.

7) HawkEye 360, $58M, aerospace: Herndon, Virginia-based HawkEye 360, a defense company for space-based radio frequency data and analytics, closed a $58 million Series D-1 led by funds and accounts managed by BlackRock. Founded in 2015, the company has raised more than $362 million, per Crunchbase.

8) Collective, $50M, fintech: San Francisco-based Collective, which offers an online back-office platform for self-employed business owners, locked up a $50 million round  from a syndicate of investors including General Catalyst, QED and others. Founded in 2020, the company has raised nearly $79 million, per Crunchbase.

9) CurvaFix, $39M, medical devices: Bellevue, Washington-based CurvaFix, a developer of medical devices to repair fractures, closed a $39 million financing led by MVM Partners. Founded in 2013, the company has raised $60 million, per Crunchbase.

Big global deals

Septerna’s round was big, but it was basically matched — depending on the exchange rate — by an Australian startup.

• Sydney-based Wollemi, a global climate specialist investment firm, raised a Series A worth approximately $150 million.

Methodology

We tracked the largest announced rounds in the Crunchbase database that were raised by U.S.-based companies for the seven-day period of July 8 to July 14. Although most announced rounds are represented in the database, there could be a small time lag as some rounds are reported late in the week.

Illustration: Dom Guzman