Zephyrnet Logo

Game-changing alternatives to conventional fungicides: small RNAs and short peptides

Date:

    • Steinberg G.
    • Gurr S.J.

    Fungi, fungicide discovery and global food security.

    Fungal Genet. Biol. 2020; 144103476

    • Fones H.N.
    • et al.

    Threats to global food security from emerging fungal and oomycete crop pathogens.

    Nat. Food. 2020; 1: 332-342

    • Brauer V.S.
    • et al.

    Antifungal agents in agriculture: friends and foes of public health.

    Biomolecules. 2019; 9: 521

  • The USA lags behind other agricultural nations in banning harmful pesticides.

    Environ. Health. 2019; 18: 1-12

    • Yadav P.K.
    • et al.

    Role of aptamers in plant defense mechanism against viral diseases.

    in: Yadav G. Aptamers. Springer, 2019: 169-174

    • Taning C.N.T.
    • et al.

    Does RNAi-based technology fit within EU sustainability goals?.

    Trends Biotechnol. 2021; 39: 644-647

    • Martins V.
    • et al.

    Metabolic changes of Vitis vinifera berries and leaves exposed to Bordeaux mixture.

    Plant Physiol. Biochem. 2014; 82: 270-278

    • Alengebawy A.
    • et al.

    Heavy metals and pesticides toxicity in agricultural soil and plants: ecological risks and human health implications.

    Toxics. 2021; 9: 42

    • Katsoulas N.
    • et al.

    Current use of copper, mineral oils and sulphur for plant protection in organic horticultural crops across 10 European countries.

    Org. Agric. 2020; 10: 159-171

    • Jouzani G.S.
    • et al.

    Bacillus thuringiensis: a successful insecticide with new environmental features and tidings.

    Appl. Microbiol. Biotechnol. 2017; 101: 2691-2711

    • Tavormina P.
    • et al.

    The plant peptidome: an expanding repertoire of structural features and biological functions.

    Plant Cell. 2015; 27: 2095-2118

    • Wang G.
    • et al.

    APD3: the antimicrobial peptide database as a tool for research and education.

    Nucleic Acids Res. 2016; 44: D1087-D1093

    • Huan Y.
    • et al.

    Antimicrobial peptides: classification, design, application and research progress in multiple fields.

    Front. Microbiol. 2020; 11: 2559

    • Giacomelli L.
    • et al.

    Identification and characterization of the defensin-like gene family of grapevine.

    Mol. Plant-Microbe Interact. 2012; 25: 1118-1131

    • Velivelli S.L.S.
    • et al.

    Antifungal symbiotic peptide NCR044 exhibits unique structure and multifaceted mechanisms of action that confer plant protection.

    Proc. Natl. Acad. Sci. 2020; 117: 16043-16054

    • Umadevi P.
    • et al.

    Proteomics assisted profiling of antimicrobial peptide signatures from black pepper (Piper nigrum L.).

    Physiol. Mol. Biol. Plants. 2018; 24: 379-387

    • Marik T.
    • et al.

    Structural diversity and bioactivities of peptaibol compounds from the longibrachiatum clade of the filamentous fungal genus Trichoderma.

    Front. Microbiol. 2019; 10: 1434

    • De Zotti M.
    • et al.

    Targeted amino acid substitutions in a Trichoderma peptaibol confer activity against fungal plant pathogens and protect host tissues from Botrytis cinerea infection.

    Int. J. Mol. Sci. 2020; 21: 7521

    • Xu Q.
    • et al.

    Engineering a peptide aptamer to target calmodulin for the inhibition of Magnaporthe oryzae.

    Fungal Biol. 2019; 123: 489-496

    • Colombo M.
    • et al.

    NoPv1: a synthetic antimicrobial peptide aptamer targeting the causal agents of grapevine downy mildew and potato late blight.

    Sci. Rep. 2020; 10: 17574

    • Lee S.C.
    • et al.

    Novel peptide-based inhibitors for microtubule polymerization in Phytophthora capsici.

    Int. J. Mol. Sci. 2019; 20: 2641

    • Fire A.
    • et al.

    Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

    Nature. 1998; 391: 806-811

    • Wang M.
    • et al.

    Bidirectional cross-kingdom RNAi and fungal uptake of external RNAs confer plant protection.

    Nat. Plants. 2016; 2: 16151

    • Nerva L.
    • et al.

    Double-stranded RNAs (dsRNAs) as a sustainable Tool against gray mold (Botrytis cinerea) in grapevine: effectiveness of different application methods in an open-air environment.

    Biomolecules. 2020; 10: 200

    • Cai Q.
    • et al.

    Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes.

    Science. 2018; 360: 1126-1129

    • Qiao L.
    • et al.

    Spray-induced gene silencing for disease control is dependent on the efficiency of pathogen RNA uptake.

    Plant Biotechnol. J. 2021; ()

    • Haile Z.M.
    • et al.

    Double-stranded RNA targeting Dicer-like genes compromises the pathogenicity of Plasmopara viticola on grapevine.

    Front. Plant Sci. 2021; 12667539

    • McLoughlin A.G.
    • et al.

    Identification and application of exogenous dsRNA confers plant protection against Sclerotinia sclerotiorum and Botrytis cinerea.

    Sci. Rep. 2018; 8: 7320

    • Gaffar F.Y.
    • et al.

    Different components of the RNA interference machinery are required for conidiation, ascosporogenesis, virulence, deoxynivalenol production, and fungal inhibition by exogenous double-stranded RNA in the head blight pathogen Fusarium graminearum.

    Front. Microbiol. 2019; 10: 1662

    • Gu K.X.
    • et al.

    A β2-tubulin dsRNA derived from Fusarium asiaticum confers plant resistance to multiple phytopathogens and reduces fungicide resistance.

    Pestic. Biochem. Physiol. 2019; 153: 36-46

    • Song X.S.
    • et al.

    Secondary amplification of siRNA machinery limits the application of spray-induced gene silencing.

    Mol. Plant Pathol. 2018; 19: 2543-2560

    • Lee T.H.
    • et al.

    Antimicrobial peptide structure and mechanism of action: a focus on the role of membrane structure.

    Curr. Top. Med. Chem. 2015; 16: 25-39

    • Parisi K.
    • et al.

    The evolution, function and mechanisms of action for plant defensins.

    Semin. Cell Dev. Biol. 2019; 88: 107-118

    • Henriques S.T.
    • et al.

    Cell-penetrating peptides and antimicrobial peptides: how different are they?.

    Biochem. J. 2006; 399: 1-7

    • Ulmschneider J.P.

    Charged antimicrobial peptides can translocate across membranes without forming channel-like pores.

    Biophys. J. 2017; 113: 73-81

    • Sakamoto K.
    • et al.

    Direct entry of cell-penetrating peptide can be controlled by maneuvering the membrane curvature.

    Sci. Rep. 2021; 11: 31

    • van der Weerden N.L.
    • et al.

    The plant defensin, NaD1, enters the cytoplasm of Fusarium oxysporum hyphae.

    J. Biol. Chem. 2008; 283: 14445-14452

    • Järvå M.
    • et al.

    X-ray structure of a carpet-like antimicrobial defensin-phospholipid membrane disruption complex.

    Nat. Commun. 2018; 9: 1962

    • Van Der Weerden N.L.
    • et al.

    Permeabilization of fungal hyphae by the plant defensin NaD1 occurs through a cell wall-dependent process.

    J. Biol. Chem. 2010; 285: 37513-37520

    • Ramamoorthy V.
    • et al.

    Glucosylceramide synthase is essential for alfalfa defensin-mediated growth inhibition but not for pathogenicity of Fusarium graminearum.

    Mol. Microbiol. 2007; 66: 771-786

    • Spelbrink R.G.
    • et al.

    Differential antifungal and calcium channel-blocking activity among structurally related plant defensins.

    Plant Physiol. 2004; 135: 2055-2067

    • Stoppacher N.
    • et al.

    The comprehensive peptaibiotics database.

    Chem. Biodivers. 2013; 10: 734-743

    • Milov A.D.
    • et al.

    Review conformation, self-aggregation, and membrane interaction of peptaibols as studied by pulsed electron double resonance spectroscopy.

    Pept. Sci. 2016; 106: 6-24

    • Afanasyeva E.F.
    • et al.

    Peptide antibiotic trichogin in model membranes: self-association and capture of fatty acids.

    Biochimica et Biophysica Acta (BBA)-Biomembranes. 2019; 1861: 524-531

    • Shi M.
    • et al.

    Antimicrobial peptaibols from Trichoderma pseudokoningii induce programmed cell death in plant fungal pathogens.

    Microbiology. 2012; 158: 166-175

    • Zhao P.
    • et al.

    Antimicrobial peptaibols, trichokonins, inhibit mycelial growth and sporulation and induce cell apoptosis in the pathogenic fungus Botrytis cinerea.

    Appl. Biochem. Microbiol. 2018; 54: 396-403

    • Cai Q.
    • et al.

    Cross-kingdom RNA trafficking and environmental RNAi – nature’s blueprint for modern crop protection strategies.

    Curr. Opin. Microbiol. 2018; 46: 58-64

    • Huang C.Y.
    • et al.

    Small RNAs – big players in Plant–microbe interactions.

    Cell Host Microbe. 2019; 26: 173-182

    • Weiberg A.
    • et al.

    Fungal small RNAs suppress plant immunity by hijacking host RNA interference pathways.

    Science. 2013; 342: 118-123

    • Zeng
    • et al.

    Cross-kingdom Small RNAs among animals, plants and microbes.

    Cells. 2019; 8: 371

    • Uslu V.V.
    • et al.

    High-pressure-sprayed double stranded RNA does not induce RNA interference of a reporter gene.

    Front. Plant Sci. 2020; 11534391

    • Das K.
    • et al.

    Expression of antimicrobial peptide snakin-1 confers effective protection in rice against sheath blight pathogen, Rhizoctonia solani.

    Plant Biotechnol. Rep. 2021; 15: 39-54

    • Niu L.
    • et al.

    Enhanced tolerance to Phytophthora root and stem rot by over-expression of the plant antimicrobial peptide CaAMP1 gene in soybean.

    BMC Genet. 2020; 21: 1-10

    • Cai Q.
    • et al.

    Small RNAs and extracellular vesicles: New mechanisms of cross-species communication and innovative tools for disease control.

    PLoS Pathog. 2019; 15e1008090

    • Song Y.
    • Thomma B.P.H.J.

    Host-induced gene silencing compromises Verticillium wilt in tomato and Arabidopsis.

    Mol. Plant Pathol. 2018; 19: 77-89

    • Capriotti L.
    • et al.

    Biotechnological approaches: gene overexpression, gene silencing, and genome editing to control fungal and oomycete diseases in grapevine.

    Int. J. Mol. Sci. 2020; 21: 5701

    • Koch A.
    • Kogel K.H.

    New wind in the sails: improving the agronomic value of crop plants through RNAi-mediated gene silencing.

    Plant Biotechnol. J. 2014; 12: 821-831

    • Khajuria C.
    • et al.

    Development and characterization of the first dsRNA-resistant insect population from western corn rootworm, Diabrotica virgifera virgifera LeConte.

    PLoS One. 2018; 13e0197059

    • Wang M.
    • Jin H.

    Spray-induced gene silencing: a powerful innovative strategy for crop protection.

    Trends Microbiol. 2017; 25: 4-6

    • Mezzetti B.
    • et al.

    RNAi: what is its position in agriculture?.

    J. Pest. Sci. 2020; 93: 1125-1130

    • Gebremichael D.E.
    • et al.

    RNA interference strategies for future management of plant pathogenic fungi: prospects and challenges.

    Plants. 2021; 10: 650

    • Fischer J.
    • et al.

    Targeted drug delivery in plants: enzyme-responsive lignin nanocarriers for the curative treatment of the worldwide grapevine trunk disease Esca.

    Adv. Sci. 2019; 61802315

    • Mitter N.
    • et al.

    Clay nanosheets for topical delivery of RNAi for sustained protection against plant viruses.

    Nat. Plants. 2017; 3: 16207

    • Thagun C.
    • et al.

    Simultaneous introduction of multiple biomacromolecules into plant cells using a cell-penetrating peptide nanocarrier.

    Nanoscale. 2020; 12: 18844-18856

    • Yoshizumi T.
    • et al.

    Selective gene delivery for integrating exogenous DNA into plastid and mitochondrial genomes using peptide–DNA complexes.

    Biomacromolecules. 2018; 19: 1582-1591

    • Gillet F.X.
    • et al.

    Investigating engineered ribonucleoprotein particles to improve oral RNAi delivery in crop insect pests.

    Front. Physiol. 2017; 8: 256

    • Terada K.
    • et al.

    Artificial cell-penetrating peptide containing periodic α-aminoisobutyric acid with long-term internalization efficiency in human and plant cells.

    ACS Biomater. Sci. Eng. 2020; 6: 3287-3298

    • Schwinges P.
    • et al.

    A bifunctional dermaseptin-thanatin dipeptide functionalizes the crop surface for sustainable pest management.

    Green Chem. 2019; 21: 2316-2325

    • Duman-Scheel M.

    Saccharomyces cerevisiae (baker’s yeast) as an interfering RNA expression and delivery system.

    Curr. Drug Targets. 2019; 20: 942-952

    • De S.
    • et al.

    Established tools and emerging trends for the production of recombinant proteins and metabolites in Pichia pastoris.

    Essays Biochem. 2021; 65: 293-307

    • Nieto-Taype M.A.
    • et al.

    Continuous cultivation as a tool toward the rational bioprocess development with Pichia pastoris cell factory.

    Front. Bioeng. Biotechnol. 2020; 8: 632

    • Tavares L.S.
    • et al.

    Antimicrobial activity of recombinant Pg-AMP1, a glycine-rich peptide from guava seeds.

    Peptides. 2012; 37: 294-300

    • Gaglione R.
    • et al.

    Cost-effective production of recombinant peptides in Escherichia coli.

    New Biotechnol. 2019; 51: 39-48

    • Gentilucci L.
    • et al.

    Chemical modifications designed to improve peptide stability: incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclization.

    Curr. Pharm. Des. 2010; 16: 3185-3203

    • Arpaia S.
    • et al.

    Biosafety of GM crop plants expressing dsRNA: data requirements and EU regulatory considerations.

    Front. Plant Sci. 2020; 11: 940

  • Phytophthora infestans: the itinerant invader; ‘late blight’: the persistent disease.

    Phytoparasitica. 2020; 48: 87-94

    • Dean R.
    • et al.

    The Top 10 fungal pathogens in molecular plant pathology.

    Mol. Plant Pathol. 2012; 13: 414-430

    • Bosland P.W.

    Think global, breed local: specificity and complexity of Phytophthora capsici.

    in: Proceedings of the 19th International Pepper Conference. International Pepper Community, Atlantic City, NJ2008

    • Buonassisi D.
    • et al.

    Breeding for grapevine downy mildew resistance: a review of ‘omics’ approaches.

    Euphytica. 2017; 213: 103

    • Marburger D.A.
    • et al.

    Impact of Fusarium graminearum on early-season soybean growth and seed yield under field conditions.

    Can. J. Plant Pathol. 2017; 39: 464-474

    • Wilson W.W.
    • et al.

    Economic impact of USWBSI’s Scab initiative to reduce FHB.

    Agribus. Appl. Econ. 2017; 774: 1-149

    • Nalley L.
    • et al.

    Economic and environmental impact of rice blast pathogen (Magnaporthe oryzae) alleviation in the United States.

    PLoS One. 2016; 11e0167295

    • Luciano-Rosario D.
    • et al.

    Penicillium expansum: biology, omics, and management tools for a global postharvest pathogen causing blue mould of pome fruit.

    Mol. Plant Pathol. 2020; 21: 1391-1404

    • Schumann G.L.
    • D’Arcy C.J.

    Late blight of potato and tomato.

    Plant Health Instr. 2000; ()

    • Feliziani E.
    • Romanazzi G.

    Postharvest decay of strawberry fruit: Etiology, epidemiology, and disease management.

    J. Berry Res. 2016; 6: 47-63

    • Gourgues M.
    • et al.

    The tetraspanin BcPls1 is required for appressorium-mediated penetration of Botrytis cinerea into host plant leaves.

    Mol. Microbiol. 2003; 51: 619-629

    • Sagehashi Y.
    • et al.

    Partial peptides from rice defensin OsAFP1 exhibited antifungal activity against the rice blast pathogen Pyricularia oryzae.

    J. Pestic. Sci. 2017; 42: 172-175

    • Tóth L.
    • et al.

    Biofungicidal potential of Neosartorya (Aspergillus) fischeri antifungal protein NFAP and novel synthetic γ-core peptides.

    Front. Microbiol. 2020; 11: 820

    • Brand G.D.
    • et al.

    Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells.

    J. Biol. Chem. 2002; 277: 49332-49340

    • Sundaresha S.
    • et al.

    Spraying of dsRNA molecules derived from Phytophthora infestans, as a plant protection strategies for the management of potato late blight.

    Preprints. 2021; ()

    • Koch A.
    • et al.

    An RNAi-based control of Fusarium graminearum infections through spraying of long dsRNAs involves a plant passage and is controlled by the fungal silencing machinery.

    PLoS Pathog. 2016; 12e1005901

    • Forster H.
    • Shuai B.

    Exogenous siRNAs against chitin synthase gene suppress the growth of the pathogenic fungus Macrophomina phaseolina.

    Mycologia. 2020; 112: 699-710

    • Yin C.
    • et al.

    Silencing Dicer-like genes reduces virulence and sRNA generation in Penicillium italicum, the cause of citrus blue mold.

    Cells. 2020; 9: 363

    • Colombo M.
    • et al.

    Peptide aptamers: the versatile role of specific protein function inhibitors in plant biotechnology.

    J. Integr. Plant Biol. 2015; 57: 892-901

    • Mehla J.
    • et al.

    A comparison of two-hybrid approaches for detecting protein–protein interactions.

    Methods Enzymol. 2017; 586: 333-358

    • Hoppe-Seyler F.
    • et al.

    Peptide aptamers: specific inhibitors of protein function.

    Curr. Mol. Med. 2004; 4: 529-538

    • Joung J.K.
    • et al.

    A bacterial two-hybrid selection system for studying protein–DNA and protein–protein interactions.

    Proc. Natl. Acad. Sci. 2000; 97: 7382-7387

    • Smith G.P.
    • Petrenko V.A.

    Phage display.

    Chem. Rev. 1997; 97: 391-410

    • Bowman S.M.
    • Free S.J.

    The structure and synthesis of the fungal cell wall.

    Bioessays. 2006; 28: 799-808

  • Fungal cell wall organization and biosynthesis.

    Adv. Genet. 2013; 81: 33-82

    • Mélida H.
    • et al.

    Analyses of extracellular carbohydrates in oomycetes unveil the existence of three different cell wall types.

    Eukaryot. Cell. 2013; 12: 194-203

    • Hinkel L.
    • Ospina-Giraldo M.D.

    Structural characterization of a putative chitin synthase gene in Phytophthora spp. and analysis of its transcriptional activity during pathogenesis on potato and soybean plants.

    Curr. Genet. 2017; 63: 909-921

    • Klinter S.
    • et al.

    Diversity and evolution of chitin synthases in oomycetes (Straminipila: Oomycota).

    Mol. Phylogenet. Evol. 2019; 139106558

    • Guerriero G.
    • et al.

    Chitin synthases from Saprolegnia are involved in tip growth and represent a potential target for anti-oomycete drugs.

    PLoS Pathog. 2010; 6e1001070

    • Samalova M.
    • et al.

    The β-1,3-glucanosyltransferases (Gels) affect the structure of the rice blast fungal cell wall during appressorium-mediated plant infection.

    Cell. Microbiol. 2017; 19e12659

    • Geoghegan I.
    • et al.

    The role of the fungal cell wall in the infection of plants.

    Trends Microbiol. 2017; 25: 957-967

    • Latgé J.P.

    The cell wall: a carbohydrate armour for the fungal cell.

    Mol. Microbiol. 2007; 66: 279-290

    • Denning D.W.

    Echinocandin antifungal drugs.

    Lancet. 2003; 362: 1142-1151

    • Grenville-Briggs L.J.
    • et al.

    Cellulose synthesis in Phytophthora infestans is required for normal appressorium formation and successful infection of potato.

    Plant Cell. 2008; 20: 720-738

    • Kong L.A.
    • et al.

    Different chitin synthase genes are required for various developmental and plant infection processes in the rice blast fungus Magnaporthe oryzae.

    PLoS Pathog. 2012; 8e1002526

    • Soulie M.C.
    • et al.

    Botrytis cinerea virulence is drastically reduced after disruption of chitin synthase class III gene (Bcchs3a).

    Cell. Microbiol. 2006; 8: 1310-1321

  • PlatoAi. Web3 Reimagined. Data Intelligence Amplified.
    Click here to access.

    Source: https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(21)00174-8?rss=yes

    spot_img

    Latest Intelligence

    spot_img