Food safety. World Health Organization https://www.who.int/health-topics/food-safety/ (2020).
Devleesschauwer, B., Haagsma, J. A., Mangen, M.-J. J., Lake, R. J. & Havelaar, A. H. in Food Safety Economics, Food Microbiology and Food Safety (ed. Roberts, T.) 107–122 (Springer, 2018).
Fritsche, J. Recent developments and digital perspectives in food safety and authenticity. J. Agric. Food Chem. 66, 7562–7567 (2018).
Zhang, L., Peng, D., Liang, R.-P. & Qiu, J.-D. Graphene-based optical nanosensors for detection of heavy metal ions. Trends Anal. Chem. 102, 280–289 (2018).
Wang, D. et al. Functionalized copper nanoclusters-based fluorescent probe with aggregation-induced emission property for selective detection of sulfide ions in food additives. J. Agric. Food Chem. 68, 11301–11308 (2020).
Tang, N. et al. A fully integrated wireless flexible ammonia sensor fabricated by soft nano-lithography. ACS Sens. 4, 726–732 (2019).
Xiao, X. et al. Rational engineering of chromic material as near-infrared ratiometric fluorescent nanosensor for H2S monitoring in real food samples. Sens. Actuators B 323, 128707 (2020).
Yang, T. et al. Real-time monitoring of pesticide translocation in tomato plants by surface-enhanced Raman spectroscopy. Anal. Chem. 91, 2093–2099 (2019).
Wu, Y. et al. Engineered gold nanoparticles as multicolor labels for simultaneous multi-mycotoxin detection on the immunochromatographic test strip nanosensor. Sens. Actuators B 316, 128107 (2020).
Wang, Y., Schill, K. M., Fry, H. C. & Duncan, T. V. A quantum dot nanobiosensor for rapid detection of botulinum neurotoxin serotype E. ACS Sens. 5, 2118–2127 (2020).
Xiong, Y., Zhang, D., Hao, Y., Liu, Y. & Si, M. Label-free detection of wild mushrooms DNA based on surface-enhanced Raman spectroscopy. J. Raman Spectrosc. 51, 46–54 (2020).
Rippa, M. et al. Octupolar plasmonic nanosensor based on ordered arrays of triangular Au nanopillars for selective rotavirus detection. ACS Appl. Nano Mater. 3, 4837–4844 (2020).
Kearns, H., Goodacre, R., Jamieson, L. E., Graham, D. & Faulds, K. SERS detection of multiple antimicrobial-resistant pathogens using nanosensors. Anal. Chem. 89, 12666–12673 (2017).
Jimenez-Falcao, S. et al. Enzyme-controlled mesoporous nanosensor for the detection of living Saccharomyces cerevisiae. Sens. Actuators B 303, 127197 (2020).
Ehgartner, J. et al. Simultaneous determination of oxygen and pH inside microfluidic devices using core–shell nanosensors. Anal. Chem. 88, 9796–9804 (2016).
Gupta, S. P., Pawbake, A. S., Sathe, B. R., Late, D. J. & Walke, P. S. Superior humidity sensor and photodetector of mesoporous ZnO nanosheets at room temperature. Sens. Actuators B 293, 83–92 (2019).
Borisov, S. M., Mayr, T. & Klimant, I. Poly(styrene-block-vinylpyrrolidone) beads as a versatile material for simple fabrication of optical nanosensors. Anal. Chem. 80, 573–582 (2008).
Nanotechnologies—Vocabulary—Part 1: Core Terms ISO/TS 80004-1:2015(en) (ISO, 2015).
Wang, Y. & Duncan, T. V. Nanoscale sensors for assuring the safety of food products. Curr. Opin. Biotechnol. 44, 74–86 (2017).
Duncan, T. V. Applications of nanotechnology in food packaging and food safety: barrier materials, antimicrobials and sensors. J. Colloid Interface Sci. 363, 1–24 (2011).
Caon, T., Martelli, S. M. & Fakhouri, F. M. in Nanobiosensors (ed. Grumezescu, A. M.) 773–804 (Academic Press, 2017).
Srivastava, A. K., Dev, A. & Karmakar, S. Nanosensors and nanobiosensors in food and agriculture. Environ. Chem. Lett. 16, 161–182 (2018).
Vikesland, P. J. Nanosensors for water quality monitoring. Nat. Nanotechnol. 13, 651–660 (2018).
Giraldo, J. P., Wu, H., Newkirk, G. M. & Kruss, S. Nanobiotechnology approaches for engineering smart plant sensors. Nat. Nanotechnol. 14, 541–553 (2019).
Schebesta, H. & Candel, J. J. L. Game-changing potential of the EU’s Farm to Fork Strategy. Nat. Food 1, 586–588 (2020).
Langer, J. et al. Present and future of surface-enhanced Raman scattering. ACS Nano 14, 28–117 (2020).
Fuertes, G. et al. Intelligent packaging systems: sensors and nanosensors to monitor food quality and safety. J. Sens. 2016, 4046061 (2016).
Kempahanumakkagari, S., Deep, A., Kim, K.-H., Kumar Kailasa, S. & Yoon, H.-O. Nanomaterial-based electrochemical sensors for arsenic—a review. Biosens. Bioelectron. 95, 106–116 (2017).
Weng, X., Chen, L., Neethirajan, S. & Duffield, T. Development of quantum dots-based biosensor towards on-farm detection of subclinical ketosis. Biosens. Bioelectron. 72, 140–147 (2015).
Weerathunge, P. et al. Ultrasensitive colorimetric detection of murine norovirus using NanoZyme aptasensor. Anal. Chem. 91, 3270–3276 (2019).
Yang, T. et al. Mapping of pesticide transmission on biological tissues by surface enhanced Raman microscopy with a gold nanoparticle mirror. ACS Appl. Mater. Interfaces 11, 44894–44904 (2019).
Hayter, C. S., Rasmussen, E. & Rooksby, J. H. Beyond formal university technology transfer: innovative pathways for knowledge exchange. J. Technol. Transf. 45, 1–8 (2020).
Van Norman, G. A. & Eisenkot, R. Technology transfer: from the research bench to commercialization: part 2: the commercialization process. JACC Basic Transl. Sci. 2, 197–208 (2017).
What is the process of technology transfer? Centers of Disease Control and Prevention https://www.cdc.gov/os/technology/techtransfer/technology-transfer-process.htm (2021).
Héder, M. From NASA to EU: the evolution of the TRL scale in public sector innovation. Innov. J. 22, 3 (2017).
Communication from the Commission to the European Parliament, the Council, the European Economic and Social Committee and the Committee of the Regions— Preparing for Our Future: Developing A Common Strategy for Key Enabling Technologies in the EU (Commission of the European Communities, 2009).
Milana, S. The lab-to-fab journey of 2D materials. Nat. Nanotechnol. 14, 919–921 (2019).
Paliwal, R., Babu, R. J. & Palakurthi, S. Nanomedicine scale-up technologies: feasibilities and challenges. AAPS PharmSciTech 15, 1527–1534 (2014).
Fadel, T. R. et al. Toward the responsible development and commercialization of sensor nanotechnologies. ACS Sens. 1, 207–216 (2016).
Stavis, S. M., Fagan, J. A., Stopa, M. & Liddle, J. A. Nanoparticle manufacturing—heterogeneity through processes to products. ACS Appl. Nano Mater. 1, 4358–4385 (2018).
Peng, H.-I., Krauss, T. D. & Miller, B. L. Aging induced Ag nanoparticle rearrangement under ambient atmosphere and consequences for nanoparticle-enhanced DNA biosensing. Anal. Chem. 82, 8664–8670 (2010).
Shi, Y., Ji, Y., Hui, F. & Lanza, M. On the ageing mechanisms of graphene-on-metal electrodes. In Proc. 10th Spanish Conference on Electron Devices (CDE) (Eds. Álvarez, Á. L. & Coya, C.) 1–4 (IEEE, 2015).
Ahn, J. J., Kim, Y., Corley, E. A. & Scheufele, D. A. Laboratory safety and nanotechnology workers: an analysis of current guidelines in the USA. NanoEthics 10, 5–23 (2016).
Lanza, G. A., Perez-Taborda, J. A. & Avila, A. Time temperature indicators (TTIs) based on silver nanoparticles for monitoring of perishables products. J. Phys. Conf. Ser. 1247, 012055 (2019).
Duncan, T. V. & Pillai, K. Release of engineered nanomaterials from polymer nanocomposites: diffusion, dissolution, and desorption. ACS Appl. Mater. Interfaces 7, 2–19 (2015).
Guidance for Industry: Preparation of Premarket Submissions for Food Contact Substances: Chemistry Recommendations (US FDA, 2007); http://www.fda.gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/IngredientsAdditivesGRASPackaging/ucm081818.htm
Werner, B. G., Koontz, J. L. & Goddard, J. M. Hurdles to commercial translation of next generation active food packaging technologies. Curr. Opin. Food Sci. 16, 40–48 (2017).
Mitter, N. & Hussey, K. Moving policy and regulation forward for nanotechnology applications in agriculture. Nat. Nanotechnol. 14, 508–510 (2019).
Horwitz, W. Evaluation of analytical methods used for regulation of foods and drugs. Anal. Chem. 54, 67–76 (1982).
Guidelines for the Validation of Chemical Methods in Food, Feed, Cosmetics, and Veterinary Products 3rd edn (US FDA, 2019).
Guidelines for the Validation of Analytical Methods for the Detection of Microbial Pathogens in Foods and Feeds 3rd edn (US FDA, 2019).
Appendix K: Guidelines for Dietary Supplements and Botanicals, Part 1 AOAC Guidelines for Single-Laboratory Validation of Chemical Methods for Dietary Supplements and Botanicals (AOAC International, 2013).
UN FAO Codex Alimentarius Commission Procedural Manual 21st edn (Secretariat of the Joint FAO/WHO Food Standards Programme, 2014).
Taverniers, I., De Loose, M. & Van Bockstaele, E. Trends in quality in the analytical laboratory. I. Traceability and measurement uncertainty of analytical results. Trends Anal. Chem. 23, 480–490 (2004).
Faucher, S., Le Coustumer, P. & Lespes, G. Nanoanalytics: history, concepts, and specificities. Environ. Sci. Pollut. Res. 26, 5267–5281 (2019).
Taverniers, I., De Loose, M. & Van Bockstaele, E. Trends in quality in the analytical laboratory. II. Analytical method validation and quality assurance. Trends Anal. Chem. 23, 535–552 (2004).
Horwitz, W. Problems of sampling and analytical methods. J. AOAC 59, 1197–1203 (1976).
Tsai-hsuan, Ku. S. Forming interdisciplinary expertise: one organization’s journey on the road to translational nanomedicine. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 4, 366–377 (2012).
Faigman, D. L., Slobogin, C. & Monahan, J. Gatekeeping science: using the structure of scientific research to distinguish between admissibility and weight in expert testimony. Northwest. Univ. Law Rev. 110, 859–904 (2016).
Faigman, D. L. Is science different for lawyers? Science 297, 339–340 (2002).
Rodricks, J. V. in Reference Manual on Scientific Evidence 3rd edn (ed. Council, N. R.) 503–548 (National Academies Press, 2011).
Murphy, M. J. in Veterinary Toxicology 3rd edn (ed Gupta, R. C.) 173–194 (Academic Press, 2018).
Report to the President—Forensic Science in Criminal Courts: Ensuring Scientific Validity of Feature-Comparison Methods (Executive Office of the President of the United States, President’s Council of Advisors on Science and Technology, 2016).
Muehlethaler, C., Leona, M. & Lombardi, J. R. Towards a validation of surface-enhanced Raman scattering (SERS) for use in forensic science: repeatability and reproducibility experiments. Forensic Sci. Int. 268, 1–13 (2016).
Popa, C., Holvoet, K., Van Montfort, T., Groeneveld, F. & Simoens, S. Risk–return analysis of the biopharmaceutical industry as compared to other industries. Front. Pharmacol. 9, 1108 (2018).
Ledley, F. D., McCoy, S. S., Vaughan, G. & Cleary, E. G. Profitability of large pharmaceutical companies compared with other large public companies. JAMA 323, 834–843 (2020).
Han, J.-W., Ruiz-Garcia, L., Qian, J.-P. & Yang, X.-T. Food packaging: a comprehensive review and future trends. Compr. Rev. Food Sci. Food Saf. 17, 860–877 (2018).
Chowdhury, P., Gogoi, M., Borchetia, S. & Bandyopadhyay, T. Nanotechnology applications and intellectual property rights in agriculture. Environ. Chem. Lett. 15, 413–419 (2017).
Morris, E. M. The irrelevance of nanotechnology patents. Conn. Law Rev. 49, 499–552 (2016).
Zingg, R. & Fischer, M. The nanotechnology patent thicket revisited. J. Nanopart. Res. 20, 267 (2018).
Rothaermel, F. T. & Thursby, M. The nanotech versus the biotech revolution: sources of productivity in incumbent firm research. Res. Policy 36, 832–849 (2007).
Atalla, K. et al. in Wireless Computing in Medicine (ed Eshaghian‐Wilner, M. M.) 567–600 (Wiley, 2016).
Genet, C., Errabi, K. & Gauthier, C. Which model of technology transfer for nanotechnology? A comparison with biotech and microelectronics. Technovation 32, 205–215 (2012).
Wu, L., Zhu, H., Chen, H. & Roco, M. C. Comparing nanotechnology landscapes in the US and China: a patent analysis perspective. J. Nanopart. Res. 21, 180 (2019).
Weiss, K. D. & Almeda, L. G. Competitive intelligence—understanding current trends in the patent landscape for nanomaterials. In Proc. 17th IEEE 17th International Conference on Nanotechnology (IEEE-NANO) 1003–1009 (IEEE, 2017).
Tahmooresnejad, L. & Beaudry, C. Collaboration or funding: lessons from a study of nanotechnology patenting in Canada and the United States. J. Technol. Transf. 44, 741–777 (2019).
Rausand, M. & Utne, I. B. Product safety—principles and practices in a life cycle perspective. Saf. Sci. 47, 939–947 (2009).
Duncan, T. V. & Singh, G. in: Nanotechnology in Foods 2nd edn (eds Chaudhry, Q. et al.) Ch. 8 (Royal Society of Chemistry, 2017).
Zhang, M. et al. Detection of engineered nanoparticles in aquatic environments: current status and challenges in enrichment, separation, and analysis. Environ. Sci. Nano 6, 709–735 (2019).
Fadeel, B. et al. Advanced tools for the safety assessment of nanomaterials. Nat. Nanotechnol. 13, 537–543 (2018).
Weiner, R. G., Sharma, A., Xu, H., Gray, P. J. & Duncan, T. V. Assessment of mass transfer from poly(ethylene) nanocomposites containing noble-metal nanoparticles: a systematic study of embedded particle stability. ACS Appl. Nano Mater. 1, 5188–5196 (2018).
Gray, P. J. et al. Influence of different acids on the transport of CdSe quantum dots from polymer nanocomposites to food simulants. Environ. Sci. Technol. 52, 9468–9477 (2018).
Bott, J. & Franz, R. Investigations into the potential abrasive release of nanomaterials due to material stress conditions—part A: carbon black nano-particulates in plastic and rubber composites. Appl. Sci. 9, 214 (2019).
Addo Ntim, S. et al. Effects of consumer use practices on nanosilver release from commercially available food contact materials. Food Addit. Contam. A 35, 2279–2290 (2018).
Liu, C., Leng, W. & Vikesland, P. J. Controlled evaluation of the impacts of surface coatings on silver nanoparticle dissolution rates. Environ. Sci. Technol. 52, 2726–2734 (2018).
Molleman, B. & Hiemstra, T. Time, pH, and size dependency of silver nanoparticle dissolution: the road to equilibrium. Environ. Sci. Nano 4, 1314–1327 (2017).
Garg, S., Rong, H., Miller, C. J. & Waite, T. D. Oxidative dissolution of silver nanoparticles by chlorine: implications to silver nanoparticle fate and toxicity. Environ. Sci. Technol. 50, 3890–3896 (2016).
Babik, K. R., Dahm, M. M., Dunn, K. H., Dunn, K. L. & Schubauer-Berigan, M. K. Characterizing workforces exposed to current and emerging non-carbonaceous nanomaterials in the U.S. J. Occup. Environ. Hygiene 15, 44–56 (2018).
Iavicoli, I., Leso, V., Beezhold, D. H. & Shvedova, A. A. Nanotechnology in agriculture: opportunities, toxicological implications, and occupational risks. Toxicol. Appl. Pharmacol. 329, 96–111 (2017).
Salieri, B., Turner, D. A., Nowack, B. & Hischier, R. Life cycle assessment of manufactured nanomaterials: Where are we? NanoImpact 10, 108–120 (2018).
Bandodkar, A. J., Jeerapan, I. & Wang, J. Wearable chemical sensors: present challenges and future prospects. ACS Sens. 1, 464–482 (2016).
Upadhyayula, V. K. K., Gadhamshetty, V., Shanmugam, K., Souihi, N. & Tysklind, M. Advancing game changing academic research concepts to commercialization: a life cycle assessment (LCA) based sustainability framework for making informed decisions in technology valley of death (TVD). Resour. Conserv. Recycl. 133, 404–416 (2018).
Buckley, J. A., Thompson, P. B. & Whyte, K. P. Collingridge’s dilemma and the early ethical assessment of emerging technology: the case of nanotechnology enabled biosensors. Technol. Soc. 48, 54–63 (2017).
Li, Z. et al. Non-invasive plant disease diagnostics enabled by smartphone-based fingerprinting of leaf volatiles. Nat. Plants 5, 856–866 (2019).
Ye, Y. et al. Portable smartphone-based QDs for the visual onsite monitoring of fluoroquinolone antibiotics in actual food and environmental samples. ACS Appl. Mater. Interfaces 12, 14552–14562 (2020).
Su, D. et al. Smartphone-assisted robust sensing platform for on-site quantitation of 2,4-dichlorophenoxyacetic acid using red emissive carbon dots. Anal. Chem. 92, 12716–12724 (2020).
Li, Z. et al. Agricultural nanodiagnostics for plant diseases: recent advances and challenges. Nanoscale Adv. 2, 3083–3094 (2020).
Yigezu, Y. A. et al. Enhancing adoption of agricultural technologies requiring high initial investment among smallholders. Technol. Forecast. Soc. Change 134, 199–206 (2018).
Balehegn, M. et al. Improving adoption of technologies and interventions for increasing supply of quality livestock feed in low- and middle-income countries. Glob. Food Sec. 26, 100372 (2020).
Genus, A. & Stirling, A. Collingridge and the dilemma of control: towards responsible and accountable innovation. Res. Policy 47, 61–69 (2018).
Duncan, T. V. The communication challenges presented by nanofoods. Nat. Nanotechnol. 6, 683–688 (2011).
Bartolucci, C. et al. Green nanomaterials fostering agrifood sustainability. Trends Anal. Chem. 125, 115840 (2020).
Boholm, Å. & Larsson, S. What is the problem? A literature review on challenges facing the communication of nanotechnology to the public. J. Nanopart. Res. 21, 86 (2019).
Jacobsen, L. F. et al. Improving internal communication between marketing and technology functions for successful new food product development. Trends Food Sci. Technol. 37, 106–114 (2014).
Siegrist, M. Factors influencing public acceptance of innovative food technologies and products. Trends Food Sci. Technol. 19, 603–608 (2008).
Klerkx, L. & Rose, D. Dealing with the game-changing technologies of Agriculture 4.0: How do we manage diversity and responsibility in food system transition pathways? Glob. Food Sec. 24, 100347 (2020).
Zang, F. et al. Ultrasensitive ebola virus antigen sensing via 3D nanoantenna arrays. Adv. Mater. 31, 1902331 (2019).
Kurdekar, A. D. et al. Streptavidin-conjugated gold nanoclusters as ultrasensitive fluorescent sensors for early diagnosis of HIV infection. Sci. Adv. 4, eaar6280 (2018).
Agrawal, A., Majdi, J., Clouse, K. A. & Stantchev, T. Electron-beam-lithographed nanostructures as reference materials for label-free scattered-light biosensing of single filoviruses. Sensors 18, 1670 (2018).
Wang, Y., Fry, H. C., Skinner, G. E., Schill, K. M. & Duncan, T. V. Detection and quantification of biologically active botulinum neurotoxin serotypes A and B using a forster resonance energy transfer-based quantum dot nanobiosensor. ACS Appl. Mater. Interfaces 9, 31446–31457 (2017).
New Era of Smarter Food Safety: FDA’s Blueprint for the Future (US FDA, 2020).
Lynn, G. S. & Akgün, A. E. Innovation strategies under uncertainty: a contingency approach for new product development. Eng. Manage. J. 10, 11–18 (1998).
Checkout PrimeXBT
Trade with the Official CFD Partners of AC Milan
Source: https://www.nature.com/articles/s41565-021-00867-7
