Uhlén, M. et al. Tissue-based map of the human proteome. Science 347, 1260419–1260419 (2015).
Miwa, H., Dimatteo, R., de Rutte, J., Ghosh, R. & Di Carlo, D. Single-cell sorting based on secreted products for functionally defined cell therapies. Microsyst. Nanoeng. 8, 84 (2022).
Levy, O. et al. Shattering barriers toward clinically meaningful MSC therapies. Sci. Adv. 6, eaba6884 (2020).
Kode, J. A., Mukherjee, S., Joglekar, M. V. & Hardikar, A. A. Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration. Cytotherapy 11, 377–391 (2009).
Bode, D., Cull, A. H., Rubio-Lara, J. A. & Kent, D. G. Exploiting single-cell tools in gene and cell therapy. Front. Immunol. 12, 2775 (2021).
Lee, S., De Rutte, J., Dimatteo, R., Koo, D. & Di Carlo, D. Scalable fabrication and use of 3D structured microparticles spatially functionalized with biomolecules. ACS Nano 16, 38–49 (2022).
De Rutte, J. et al. Suspendable hydrogel nanovials for massively parallel single-cell functional analysis and sorting. ACS Nano 16, 7242–7257 (2022).
de Rutte, J., Dimatteo, R., Zhu, S., Archang, M. M. & Di Carlo, D. Sorting single-cell microcarriers using commercial flow cytometers. SLAS Technol. 27, 150–159 (2022).
Stoeckius, M. et al. Simultaneous epitope and transcriptome measurement in single cells. Nat. Methods 14, 865–868 (2017).
Peterson, V. M. et al. Multiplexed quantification of proteins and transcripts in single cells. Nat. Biotechnol. 35, 936–939 (2017).
Thej, C., Ramadasse, B., Walvekar, A., Majumdar, A. S. & Balasubramanian, S. Development of a surrogate potency assay to determine the angiogenic activity of Stempeucel®, a pooled, ex-vivo expanded, allogeneic human bone marrow mesenchymal stromal cell product. Stem Cell. Res. Ther. 8, 1–14 (2017).
Berry, J. D. et al. NurOwn, phase 2, randomized, clinical trial in patients with ALS. Neurology 93, e2294–e2305 (2019).
Yousefi, K. et al. The design and rationale of a phase 2b, randomized, double-blinded, and placebo-controlled trial to evaluate the safety and efficacy of lomecel-B in older adults with frailty. J. Frailty Aging 11, 214–223 (2022).
Mereu, E. et al. Benchmarking single-cell RNA-sequencing protocols for cell atlas projects. Nat. Biotechnol. 38, 747–755 (2020).
Koch, F. et al. Generic method of printing window adjustment for extrusion-based 3D-bioprinting to maintain high viability of mesenchymal stem cells in an alginate-gelatin hydrogel. Bioprinting 20, e00094 (2020).
Schwartz, M. A. & Assoian, R. K. Integrins and cell proliferationregulation of cyclin-dependent kinases via cytoplasmic signaling pathways. J. Cell Sci. 114, 2553–2560 (2001).
Potier, E. et al. Hypoxia affects mesenchymal stromal cell osteogenic differentiation and angiogenic factor expression. Bone 40, 1078–1087 (2007).
Liu, G.-S. et al. Pharmacological priming of adipose-derived stem cells for paracrine VEGF production with deferoxamine. J. Tissue Eng. Regen. Med. 10, E167–E176 (2016).
Waters, J. A., Urbano, I., Robinson, M. & House, C. D. Insulin-like growth factor binding protein 5: diverse roles in cancer. Front. Oncol. 12, 1052457 (2022).
Sureshbabu, A. et al. IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF-7 human breast cancer cells. J. Cell Sci. 125, 1693–1705 (2012).
Al Halawani, A., Abdulkhalek, L., Mithieux, S. M. & Weiss, A. S. Tropoelastin promotes the formation of dense, interconnected endothelial networks. Biomolecules 11, 1318 (2021).
Zheng, H., Fu, G., Dai, T. & Huang, H. Migration of endothelial progenitor cells mediated by stromal cell-derived factor-1alpha/CXCR4 via PI3K/Akt/eNOS signal transduction pathway. J. Cardiovasc. Pharmacol. 50, 274–280 (2007).
Chou, C. H. et al. SCUBE3 regulation of early lung cancer angiogenesis and metastatic progression. Clin. Exp. Metastasis 30, 741–752 (2013).
Fan, D. & Kassiri, Z. Biology of tissue inhibitor of metalloproteinase 3 (TIMP3), and its therapeutic implications in cardiovascular pathology. Front. Physiol. 11, 661 (2020).
Poss, K. D. & Tonegawa, S. Heme oxygenase 1 is required for mammalian iron reutilization. Proc. Natl Acad. Sci. USA 94, 10919 (1997).
Lenselink, E. A. Role of fibronectin in normal wound healing. Int. Wound J. 12, 313 (2015).
DiFeo, A., Martignetti, J. A. & Narla, G. The role of KLF6 and its splice variants in cancer therapy. Drug Resist. Updat. 12, 1–7 (2009).
Higuchi, M. et al. PRRX1- and PRRX2-positive mesenchymal stem/progenitor cells are involved in vasculogenesis during rat embryonic pituitary development. Cell Tissue Res. 361, 557–565 (2015).
Dong, Y. et al. RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development 137, 1461–1471 (2010).
Han, H. et al. TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions. Nucleic Acids Res. 46, D380–D386 (2018).
Cheng, R. Y.-H. et al. SEC-seq: association of molecular signatures with antibody secretion in thousands of single human plasma cells. Nat. Commun. 14, 3567 (2023).
Shum, E. Y., Walczak, E. M., Chang, C. & Christina Fan, H. Quantitation of mRNA transcripts and proteins using the BD RhapsodyTM single-cell analysis system. Adv. Exp. Med. Biol. 1129, 63–79 (2019).
Trzupek, D. et al. Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis. Genome Med. 12, 55 (2020).
Vanuytsel, K. et al. Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment. Nat. Commun. 13, 1103 (2022).
Wu, T. et al. Time-resolved assessment of single-cell protein secretion by sequencing. Nat. Methods 20, 723–734 (2023).
Xie, Z. et al. Single-cell RNA sequencing analysis of human bone-marrow-derived mesenchymal stem cells and functional subpopulation identification. Exp. Mol. Med. 54, 483–492 (2022).
Sun, C. et al. Single-cell RNA-seq highlights heterogeneity in human primary Wharton’s jelly mesenchymal stem/stromal cells cultured in vitro. Stem Cell Res. Ther. 11, 149 (2020).
Zhang, C. et al. Single-cell transcriptomic analysis reveals the cellular heterogeneity of mesenchymal stem cells. Genomics Proteom. Bioinform. 20, 70–86 (2022).
Cui, Y. et al. Single-cell characterization of monolayer cultured human dental pulp stem cells with enhanced differentiation capacity. Int. J. Oral. Sci. 13, 44 (2021).
Vistain, L. et al. Quantification of extracellular proteins, protein complexes and mRNAs in single cells by proximity sequencing. Nat. Methods 19, 1578–1589 (2022).
Baloh, R. H. et al. Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial. Nat. Med. 28, 1813–1822 (2022).
Carraro, G. et al. Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition. Nat. Med. 27, 806–814 (2021).
Chen, G. et al. Comprehensive identification and characterization of human secretome based on integrative proteomic and transcriptomic data. Front. Cell Dev. Biol. 7, 299 (2019).
Hu, H. et al. AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors. Nucleic Acids Res. 47, D33–D38 (2019).
Bausch-Fluck, D. et al. The in silico human surfaceome. Proc. Natl Acad. Sci. USA 115, E10988–E10997 (2018).
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