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Tag: inhibitor

Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner – Nature Communications

Acute platelet depletion rapidly recruits quiescent HSCs into proliferationIn line with previous studies9, administration of a single dose of anti-GPIbα antibody to Vwf-GFP mice,...

Lymphoma maintenance therapy delivers promise in CTCL

One of the largest clinical trials in cutaneous T-cell lymphoma (CTCL) to date could change current clinical practice, new data shows. Resminostat (Kinselby) has been...

Deglycosylation of eukaryotic-expressed flagellin restores adjuvanticity – npj Vaccines

EthicsAll animal experimental procedures were approved by the Chonnam National University Institutional Animal Care and Use Committee under the protocol CNU IACUC-H-2021-51. Animal research...

Datopotamab Deruxtecan Demonstrated Statistically Significant and Clinically Meaningful Progression-Free Survival Benefit in Patients with HR-Positive, HER2-Low or Negative Breast Cancer in TROPION-Breast01 Phase III...

A trend in improvement for the dual primary endpoint of overall survival (OS) was observed for datopotamab deruxtecan versus chemotherapy. Data for OS were...

US FDA Approves Jardiance for the Treatment of Adults with Chronic Kidney Disease

RIDGEFIELD, Conn. and INDIANAPOLIS, Sept. 22, 2023 /PRNewswire/ -- The U.S. Food and Drug Administration (FDA) has approved Jardiance® (empagliflozin) 10 mg tablets to...

NICE recommends Eli Lilly ulcerative colitis biologic

The first IL-23p19 targeted biologic recommended by the National Institute for Health and Care Excellence (NICE) for moderately to severely active ulcerative colitis (UC)...

Sept. 21 Quick Takes: Catalys-backed newco buys regional rights to Inventiva NASH therapy

ARTICLE | DealsPlus: Everest takes local rights to Kezar’s lupus nephritis treatment, and updates from Celexor, GSK, Jura, Syena, Moucellion and Xungene By BioCentury Staff September...

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9 – Nature Communications

Ethics statementAll iPSC lines were previously derived from skin biopsy fibroblasts, following signed informed consent, collected under ethical approval granted by the South Wales...

Long non-coding RNA SNHG8 drives stress granule formation in tauopathies – Molecular Psychiatry

Bodea LG, Eckert A, Ittner LM, Piguet O, Götz J. Tau physiology and pathomechanisms in frontotemporal lobar degeneration. J Neurochem. 2016;138:71–94.Article  CAS  PubMed  PubMed...

mRNA vaccine quality analysis using RNA sequencing – Nature Communications

Design and synthesis of reference plasmidA reference construct was first designed, with the intention of optimising the production of RNA therapeutics for pre-clinical research....

Hope for patients with life-threatening muscle disorder after years of clinical trial failures

Duchenne muscular dystrophy (DMD) is a rare condition that is typically treated with the help of steroids, to manage symptoms, as scientists are yet...

Guidance recommending BMS cardiac myosin inhibitor published

NICE’s final guidance recommending Bristol Myers Squibb’s first-in-class obstructive hypertrophic cardiomyopathy (oHCM) drug on the NHS, is now published. Credit: HJBC / Shutterstock.comThe recommendation of...

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