Diabetic patients administered a sublingual spray containing CBD and THC show improvements in their blood sugar and cholesterol levels, according to placebo-controlled data published in the Iranian Journal of Pharmaceutical Research.

A team of Iranian investigators evaluated the efficacy of a proprietary formulation of plant-derived CBD/THC compared to placebo in a cohort of 50 patients with type 2 diabetes. Patients utilized the spray twice daily for eight weeks. The sublingual formulation contained a ten-to-one ratio of CBD to THC.

Compared to placebo, cannabinoid therapy was associated with a “statistically significant decline in total cholesterol, triglycerides, LDL-C, FBS [fasting blood glucose levels], Hb [hemoglobin] A1C, and insulin secretion … at the end of the 8-week treatment period. … [T]here were no statistically significant differences in reported adverse effects between the two groups.”

Researchers concluded: “In the present study, we demonstrated that sublingual administration of [a CBD/THC] spray, … twice daily through an eight-week treatment period could effectively improve the patient’s lipid profile and glucose tolerance. … Based on these observations, the combination of CBD/Δ9-THC regimen could be a new therapeutic regimen for controlling the lipid profile and glycemic state of DM [type 2 diabetic] patients.”

Clinical trial data has previously shown that the administration of the cannabinoid…