Connect with us

zephyrnet

Frazier Healthcare Partners raises $617M fund to invest in life sciences companies

Published

on

The firm also made a series of promotions, including Dan Estes to General Partner

Developing new drugs isn’t easy, or cheap; in fact, the cost of bringing a new drug to market has been estimated to be over $2 billion. Yet, that’s one of the main areas of focus for venture firm Frazier Healthcare Partners.

The firm has a dedicated life sciences team, led by Patrick Heron, James Topper and Dan Estes, investing in therapeutics-focused companies that develop and commercialize pharmaceuticals. On Thursday, Frazier announced that it made a number of promotions, including Estes, has been at the firm since 2011, to General Partner, while also unveiling that it closed its latest fund, Frazier Life Sciences X, with more than $617 million in capital commitments.

With this, the firm, which was formed 29 years ago, has now raised roughly $4.8 billion in total.

“We do two things at Frazier: we have a private equity group based up in Seattle that invests in profitable healthcare services and pharmaceutical services companies; we call it a growth buyout strategy. I work on our life sciences venture team, based in Menlo Park, and we invest in early stage companies, developing novel therapeutics,” Estes explained to me in an interview.

While this is the tenth fund for Frazier, it’s only the third that is dedicated specifically to life sciences. The first fund, raised in 2016, was $262 million, and the second was a $419 million fund raised in 2018. Prior to that, the company would invest in both prongs out of the same fund. The reason for the split, Estes said, was that the two sides of the firm had very different investing strategies.

“Creating separate funds dedicated to growth buy out and to life sciences was a function of the fact that investment strategies and mindsets are pretty different between a late stage buyout fund, and an early stage venture fund. We basically realized that to really grow the firm it made a lot more sense to separate into two separate funds,” he said, noting that have a dedicated fund also allowed the life sciences division to bring on more institutional LPs. 

“A lot of the LPs who had supported us historically stuck with both strategics, but we were also able to bring in new investors in our funds who wanted specifically that strategy. In our first dedicated life sciences fund, we were able to attract some really high quality institutional investors, who have stuck with us across all of our life sciences specific funds, and, in our most recent fund, the vast majority of the fund was taken up by insiders, although we did add several high quality investors who were looking to add their exposure to this sector.” 

A strategy of creating new companies

When it comes to its life sciences division, Frazier invests in three types of companies: early-stage venture, late private/public opportunities, and companies that it creates itself. The last group are generally involving spin-outs from larger biopharmaceutical companies, and they represent around half of the firm’s investments, while 30 percent are other private deals, and 20 percent are public companies.  

“We are able to spin out a drug that is not being developed, for whatever reason, at a company, create a new company around it, then also bring in a team who can focus on developing that asset to make the company successful,” Estes told me. 

“We’ve got a group of entrepreneurs in residence and venture partners who are focused on talking to every pharma company, understanding what’s available, sometimes even proposing drugs that are in their pipeline that we think could make sense for a new company, and then working to spin those drugs out and form new companies.”

Frazier has created 24 companies in the past 15 years, and 14 of them have been formed in just the last five years alone. One of the most recent ones, for example, was Phathom Pharmaceuticals, a spin-out from Japanese pharma company Takeda, thanks to Frazier venture partner Tachi Yamada.

“Tachi was one of the most senior R&D executives in the world. Before joining Frazier, he was the head of R&D at Takeda, so he knows the Takeda pipeline extremely well, he developed quite a few drugs in that pipeline, and one of the drugs he developed was a drug that treats acid-related gastrointestinal disorders. It basically goes after H. pylori and other very common diseases,” said Estes.

“He developed drug in Japan, and it’s an extremely good drug that treats acid-related disorders, but he also knew that Takeda was not developing this molecule in the US and Europe. That was for various reasons, but they were choosing not to do so. So, for the past few years, he has been trying to convince Takeda, now that he’s at Frazier, to spin that drug into a new company that he would help to run and get started. After several years of having this discussion, Takeda, this year, was ready to do that.”

Having that connection to Takeda gave Frazier “unique access,” and it also allowed the firm to spin out the drug with Phathom, which went public last year. 

Another company that Frazier formed is one called Mavupharma, which was acquired last year by Abbvie. In this case, the idea to form the company came from one of Frazier’s clinical advisors, who often have decades of experience in the pharma space. 

“One of our advisors, together with a former employee at one of our companies, came up with a target that had just been described in literature. They read journals all the time and they said, ‘We think that this target could be relevant for oncology,’ and it was in a very hot pathway at the time called STING, that we knew that if you had a drug that had a certain profile on this pathway it would be attractive,” said Estes. 

Mavupharma was seeded with $1 million from Frazier, which was put toward understanding if the target was druggable, and if it would have the biological effects in cells that Frazier believed it could. Once those were proven, it was funded with a Series A round to invest more in the chemistry and biology, after which Abbvie came in and bought it. 

“Ideas come from all over the place, so it’s really important to have a broad set of people who are looking, have ideas, are following the literature, and our job as investors is to pick which ideas to go after. That’s what we’ve done pretty successfully over past funds, especially life sciences funds,” said Estes. 

Frazier expects to invest in around 8 to 10 companies a year, the vast majority of which will be private investments, at $30 to $40 million each.

Growing the team

In addition to promoting Estes to General Partner, Frazier also announced a series of promotions, including Jamie Brush to Partner; Gordon Empey to Partner and General Counsel; Aditya Kohli to Principal; and Liz Park to Vice President of Investor Relations.

Brush has been with Frazier since 2016, and has led investments in companies that include Krystal Biotech and Translate Bio. Empey, who joined in 2017, was previously a partner with biotechnology and technology law firm Cooley LLP, while Kohli, who joined the Frazier Life Sciences team in 2016, co-founded Phathom Pharmaceuticals and Scout Bio.

Park originally joined Frazier in 2003, and re-joined the firm in 2015, helping to raise nearly $1.3 billion across the three Life Sciences funds.

“I think Frazier is really unique in the investment world, especially in life sciences, because we are very focused on development of people, and we’re also very willing to promote people when they perform. A stat that we’re really proud of is Frazier, both on the life sciences and the growth buy out side, is that seven of the 10 partners in the firm started as associates and worked their way up. So, developing people is a huge focus of what we do,” said Estes.

“For me, going from partner to general partner, obviously I’m very thankful that the firm continues to believe in me, and has invested in my development. I’ve been involved with a number of successful deals we’ve done, and I particularly enjoy working on the early side, so Series A deals and company formation, and the promotion is an opportunity to keep doing more of that.”

Source: http://feeds.vator.tv/~r/vatortv/news/~3/641gCwlbEqo/2020-01-16-frazier-healthcare-partners-raises-617-fund-to-invest-in-life-sciences-companies

zephyrnet

Understanding How Trading Bots Work

Published

on

With the daily advancement of technology and financial markets, crypto trading is the new currency in town. Due to their volatility, digital assets are listed on crypto exchanges just the same way shares of limited companies and state corporations are listed on Wall Street.

The crypto market runs 24/7, with prices never stopping fluctuating depending on market forces across the world. With a huge number of active cryptocurrencies in the world and taking other considerations into perspective, no human can keep efficient track of the price changes.

This brings automated bots into the context. These bots are algorithms that are aimed to ease the trading process by providing accurate and efficient data on the cryptocurrencies a user trades with.

They are tools designed to gather and analyze market data and execute trades on behalf of traders, which basically means profiting from tiny price fluctuations.

Due to their ability to convey accurate and prompt changes in the crypto market prices, they are desirable to investors who are immersed in the trade. There are several types of automated bots for crypto trading that are available in the market.

TYPES OF BOTS 

  1. Arbitrage bots. Taking advantage of the existing market inefficiencies, arbitrage trading makes profits through the simultaneous purchase and sale of the same asset in different markets at different but close-range prices. Arbitrage relies heavily on execution speed, since it is crucial to buy an asset on one exchange and simultaneously sell it on another, but at a higher price.

Among all providers of automated trading solutions which have incorporated this feature into their platforms, the one offered by Bitsgap clearly stands out. All thanks to a variety of tools that allow analyzing data from 25 crypto exchanges around the world to find the best opportunity to strike a deal.

  1. Grid bots. Grid bots place multiple buy and sell orders within a predetermined price corridor. The orders form a grid above and below the current price — the higher the number of levels, the more intense trading will be. The rising number of grids leads to decreasing price differences between them, which reduce from each trade.

Users should be careful reducing grid spaces since some bots do not take into account exchanges’ fees when calculating profits. Bitsgap is among few platforms that include all commissions into profit calculation and simply won’t allow bots to perform a trade if it won’t make any profit for the user.

  1. Futures bots. The main advantage of futures trading is leverage, which allows traders to open positions exceeding their initial investments, thus multiplying profits. This advantage, however, is the main danger of futures trading, since it can dramatically impact the size of the portfolio and lead to a partial or even total loss of the investments.

Controlling emotions is especially hard when trading futures and this is the point where the Bitsgap Combo bot steps in. It completely automates the process by combining grid and DCA technology and uses trend reverse for maximizing profits when the trend turns in your favor.

BENEFITS OF TRADING BOTS

Just as there are demerits of using bots in blockchain trade, so are the merits. Which surpasses them by miles. This has been harnessed through the launch of the Ethereum London Hard fork. It includes:

  1. Owing to the analysis of the cryptocurrency market prices by chart patterns and trend lines, the interpretation of data becomes simplified. Investors can therefore easily read and understand graphical representations and afterwards make sound execution decisions like in trend trading bots.
  2. Non-stop trading. Bots operate 24/7 as they scale the fluctuations and variations of cryptocurrency prices. This allows investors to secure time and focus on analysis and high-profitable smart trading.
  3. Time-saving. Automated bots constantly analyze prices and trading volumes of over ten thousand trading pairs and are capable of executing thousands of trades per minute on dozens of exchanges. This kind of precision cannot be achieved by any human being, while bots perform it with ease.

MAKING PROFITS USING BOTS

Making and maximizing profits is the main investor concern. It goes without saying that the bigger the risk, the higher the profits. Similarly, the smaller the investment, the lower the return margins.

Crypto is maturing year after year. It has evolved into a prominent asset class attracting investors with promises of high returns and relatively low entry barriers. Since 2017, Bitsgap has matured with the industry and turned into one of the leading companies offering a one-stop automated solution for crypto trading.

Compared to other platforms, Bitsgap offers an unmatched set of tools across 25 crypto exchanges to build a solid trading strategy that may generate stable returns regardless of the market trend.

The company’s blog provides users with articles and ready-made automated trading solutions that allow newcomers to avoid the most common mistakes and start benefiting from crypto at once.

Source Code:Plato Data Intelligence

Continue Reading

zephyrnet

Retro Games, Meet the World of eSports

Published

on

Videogames have come a long way from the days of Pong and Space Invaders. From as far back as 60 years ago, we’ve been running, jumping and dodging projectiles on everything from arcade machines to our mobile phones. eSports have become high-earning professional competitions, with some of the more popular esports competitions sporting prize pools of millions of dollars. With a combination of technological advancement and innovative game design, we’re a far cry from the pinball machines on darkened arcade floors.

Many of us have happily been along for the ride, as technological development has brought gaming to a scale of consumer engagement rivalling that of any other major entertainment sector. One could arguably go as far as saying that our gaming experiences form a part of our personal development now. A lot of us remember our first jump in Mario, or the hours of playtime we spent in arcades. While the latest and greatest games are always drawing people in, many older videogames are still juggernauts in their own right. Nostalgia is a strong motivator, and many older titles are still quite competitive these days. If you’re somebody who loves a classic whether it’s slots, fighting games or racing sims, here’s a couple of popular retro games that prove just how significant they are to the growth of the esports genre.

Street Fighter 2

Credit via Unsplash

At the time of its release, Street Fighter 2 was an instant hit. Going on to become developer Capcom’s most successful software title, Street Fighter 2 was the first arcade game that allowed players to compete directly. It was the first game to implement a working combo-system, and inspired groups of players to begin their own competitive tournaments. Street Fighter 2 is widely regarded as one of the most influential games of all time, sparking a resurgence of arcade gaming in the 1990s, and cementing the fighting game genre as a competitive gaming mainstay. One of the top three highest-grossing video games of all time, Street Fighter 2 also had a significant impact on popular culture.

With a roster full of memorable characters, Street Fighter 2 quickly became a cultural phenomenon. With their iconic moves and unique one-liners, most of us know who Ryu and Ken are, or even some of the lesser characters like Zangief or Blanka. There are a multitude of formal and informal Street Fighter tournaments around the world – some of the biggest being the Retro World Series and the EVO fighting game tournament. Old tournaments and current matches are available to watch for anyone who’s interested, and can be viewed on Twitch and Youtube. With the upcoming release of a Nintendo Switch version, Street Fighter 2 isn’t showing signs of slowing down any time soon.

Starcraft

Credit via Pexels

Despite a highly-successful sequel, Starcraft: Brood War still has a healthy competitive scene in 2021. A decade after its release, it is still considered one of the most popular online competitive games, owed in large part to the evolution of esports in South Korea. After the growth of Starcraft’s professional tournaments, some of its best players in the world went on to become minor celebrities. The game influenced popular culture to such an extent that competitive matches were broadcast on their own dedicated television channels.

Starcraft, and real-time strategy games in general, require efficiency in a few key skills. Some of these skills include base-building, knowledge of unit combinations, production economy, and the overall speed at which you can perform all these tasks. With all of these dynamics working in realtime, there’s no pause button as you and your opponents take each other on in a game of wits and tactics. Starcraft was also one of the first games to introduce asymmetric factions, where each faction had distinct differences in playstyle and unit composition. This allowed for more variety in how matches would play out, increasing the likelihood of a surprising tactic or outcome.

Nowadays Starcraft 2 is the game you’ll find at most tournaments. However, with the Starcraft remaster that came out in 2017, the original has seen a resurgence in players and competitive matches. Turns out all you need for a popular esport is a dedicated fanbase, and a community that will support a worthy game. Despite an increase in global connectivity and communication, tournaments and classic games bring people together in a way that many modern games have difficulty achieving.

Wind-up

Modern esport games such as Fortnite, Apex Legends and Counterstrike have become household names. But there will always be those of us who love the games of yesteryear. As each generation goes through its own advancement of games development, we remember the games that we love – the ones that make an impression on us are the ones we enjoy coming back to.

The ongoing support and success of retro games clearly demonstrates the fact that graphics and processing power aren’t everything. Many of us enjoy the memories a game invokes, or the friends (and enemies) we find through competition. A well-earned victory is satisfying in any entertainment medium, and the added interactivity in games make them a unique environment for esports players and spectators alike. Healthy competition will never go out of style, and it’s nice to know that the classics won’t either.

Continue Reading

zephyrnet

Robinhood draws criticism from Wall Street as it braces for massive IPO

Published

on

Since the Robinhood trading app has drawn attention to the stability of the US stock markets. As a strategy of high access to financial markets, the app has sparked interest in the stock market from a younger group of traders keen to take on Wall Street scammers. Despite a series of crises this year. The Robinhood app is growing faster than ever and is on track to achieve a multibillion dollar IPO in the coming months.

The disruption caused by the app’s success has drawn a lot of criticism from more established players, who claim that the app makes transactions too easy and makes the investment process much less secure. While this may be true in some cases, it also proves that the availability of the app has served to hamper the business models of major industry players, who were charging investors high enough fees to trade stocks and shares on theirs. platforms. However, the success of Robinhood has forced the major brokers to improve and lower their fees to be competitive. Freedom24 is an example of a brokerage firm: dynamic and reliable, it has experience and expertise in the US stock market. It provides robust trading platforms and technologies to the market. Thanks to their brokers, investors have direct access to the stock markets and are guaranteed to be able to participate in IPOs.

The company recently took steps to mitigate some of the criticism. After being a private company for eight years, Robinhood filed in March the necessary documents to go public. Sources told CNBC that she chose the Nasdaq as her exchange. She remains on the IPO path and has built her management teams with veterans from Wall Street and Silicon Valley.

Negative PR and Blackouts Affect Robinhood

The popularity and success of Robinhood presented the young financial technology firm with its own set of challenges, including interruptions or suspensions of transactions as its IT infrastructure struggled to cope with the huge volumes transmitted. In turn, those interruptions sparked a significant amount of negative public relations, which ultimately led to a congressional hearing into the events surrounding the rise and suspension of GameStop stock earlier this year.

(Source: Intelligent Trend Follower)

Yet Robinhood is one of the fastest growing fintech startups and has become one of Silicon Valley’s most valuable private unicorns – and is the first company on this year’s CNBC Disruptor 50 list. Robinhood is valued at $ 11.7 billion, with its main backers being Sequoia Capital and Andreessen Horowitz, NEA, Kleiner Perkins and GV, the venture capital arm of Alphabet, the parent company of Google. Its IPO should allow a valuation of at least three times this amount. To prepare for its IPO, the company recruited executives with experience from Google, Facebook, Amazon, and the Securities and Exchange Commission.

In the run-up to Robinhood’s IPO, the tech unicorn has managed to tap into a previously untapped user base of new investors, who during the lock-in appear to have used their US stimulus payments to generate renewed interest in the functioning of financial markets. Maxim Manturov, head of investment research at Freedom Finance Europe, says: “One of Robinhood’s main problems is the lack of liquidity in the face of strong demand on GameStop (GME) stock. is not only that of Robinhood however, as many other brokers have also come across it when offering GME. Indeed, Robinhood had to put some limits and traders rushed to other platforms like Square, SoFi, etc. It is because of these limitations that many investors have been unhappy and have filed complaints and claims against Robinhood; the company however denies any involvement in helping third parties, as no one outside the company did not influence the decision on the limits.

During this crisis, Robinhood has seen tremendous growth in its users

It rose to the top of the iOS app store for several days during the gaming frenzy and led the industry in downloads, with 600,000 people downloading the free trading app in one. day, according to JMP Securities. In January, JMP estimated that Robinhood has gained 3 million users. As a result, venture capitalists rushed to fund Robinhood, which had to raise billions of dollars to meet its capital needs. Robinhood raised over $ 3 billion in a matter of days.

The biggest challenge Robinhood will face when it emerges on the other side of the pandemic will be keeping large numbers of these new users on board without them blowing their accounts up. They got a glimpse of the scale of this challenge earlier this year in the wake of GameStop’s volatility, which has had tragic consequences.

This is where future regulation may well act as a headwind. Product innovation is good, but leveraged investing and fractional exposure to various asset classes pose challenges when it comes to managing risk adequately and reasonably. Too often, novice traders are not sufficiently aware of the huge risks they take when trading with leverage. The rewards are important, but the risks can be even more so.

Continue Reading

zephyrnet

7th Global Blockchain Congress by Agora Group & TDeFi on June 21st and 22nd, 2021, Dubai.

Published

on

The 7th edition of the world-renowned flagship Global Blockchain Congress by Agora Group is taking place on June 21st and 22nd, 2021 in Dubai & co-hosted by TDeFi. We are also happy to have Woonkly as a Title Sponsor for this event.

This edition’s theme is “Celebrating DeFi and NFTs” and will boast an amazing line up of speakers including Keynote Addresses by His Excellency Ahmed Bin Sulayem, Executive Chairman & CEO of Dubai Multi Commodities Centre, Hubertus Thonhauser, Chairman of the Board of Tezos Foundation, Fiorenzo Manganiello, Partner at Lian Group and many others.

The event is a closed door, exclusive congress that can be attended by invitation only. Agora will be hosting more than 100 investors and 30 Sponsors (Global Blockchain, DeFi and NFTs projects looking to raise funds). 

 

The first six editions of the Global Blockchain congress were a tremendous success and we were able to host more than 450 investors and more than 90 blockchain startups and were able to raise Millions in funds for our participating projects.

 

 

This is an exclusive, closed-door Congress to connect startups with investors and secure funds.

 

Startup founders from all over the world need financial advocates on their side. Raising funds and receiving funding is vital to the growth and success of startups. NOW is the right time for international startups to tap into a pool of highly engaged investors from the MENA region who are actively looking to invest in exciting and promising companies.

“Pitches are good and all, but have you ever sat on a table for 8 hours with 30 minutes one-on-one meetings with 50 rotating investors? Agora is next level. I went to this conference last year, and it was like speed dating with investors. THIS IS EXACTLY HOW IT SHOULD BE. If you’re in Dubai or can get there, and are looking to raise funds for your project, this is your jam.”

Nikita Sachdev, Co-Founder, LunaPR.io

 

Previous Notable Speakers:

H.E. Naokazu Takemoto – Minister of State for Science and Technology Policy, Japan.

Dr. Obaid Al Zaabi – CEO, Securities & Commodities Authority, UAE.

Baiba Broka – Member of the General Council, International Institute for the Unification of Private Law, Working Group Member on Cryptocurrency Regulation, Ministry of Finance, Latvia, and Former Minister of Justice, Latvia.

Josef‌ ‌Holm‌ – Founding Partner, Draper Goren Holm

 

Kristina Lucrezia Corner – Managing Editor, Cointelegraph.

Ralf Glabischnig – Founder & Board Member, Crypto Valley Venture Capital.

H.E. Zulfiquar Ghadiyali – Executive Director Of DIHC under chairmanship of HH Sheikh Mohammed bin Sultan bin Hamdan Al Nahyan

Zachary Cefaratti – CEO & Principal Founder, Dalma Capital

Wai Lum Kwok – Senior Executive Director & Financial Services Regulatory Authority, Abu Dhabi Global Market (ADGM)

 

For participation apply here:  http://bit.ly/The7thGBC 

Official website: https://agoragroup.ae/events/global_blockchain_congress_7th_edition

Continue Reading
Esports4 days ago

Can You Play Diablo II: Resurrected Offline?

Esports4 days ago

Failed to Enter Game, Character Could Not be Found: How to Fix Error in Diablo II: Resurrected

Esports4 days ago

Valkyrae says YouTube is working on gifted members and a feature similar to Twitch Prime

Esports3 days ago

Fall Guys achieves Guinness World Record for most downloaded PlayStation Plus game ever

Esports4 days ago

Valkyrae says YouTube is working on gifted members and a feature similar to Twitch Prime

Esports23 hours ago

Twitch celebrity meetup Sh*tCamp 2021 begins today

Esports4 days ago

Microsoft’s The Initiative brings on Crystal Dynamics to help develop its Perfect Dark reboot

Esports4 days ago

How to check Diablo 2: Resurrected server status

Esports4 days ago

Best Stats for the Druid in Diablo II: Resurrected

Cyber Security5 days ago

Apple bans Epic Games from App Store

Blockchain5 days ago

United States Infrastructure Bill Brings Cardano Billionaire to Washington.

Esports4 days ago

How to play with friends in Diablo 2: Resurrected

Covid195 days ago

Florida Makes Quarantine Optional For Students Exposed To COVID-19

Esports4 days ago

Failed to Enter Game, Character Could Not be Found: How to Fix Error in Diablo II: Resurrected

Esports3 days ago

NBA 2K22 ‘Meet the Designers’ Quest Guide: How to Complete

Esports1 day ago

FIFA 22 Early Access Pack: How to Get

Esports4 days ago

NBA 2K22 Current Gen Best Big Man Build: How to Make

Esports4 days ago

How to earn operation stars in CS:GO

Esports4 days ago

Valorant Patch 3.07 Release Date: When is it?

Esports4 days ago

XCOM 3 Appears in Nvidia Data Base Leak

Trending