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Facebook says WSJ allegations are ‘mischaracterizations,’ confer ‘false motives’

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(Reuters) – Facebook Inc on Saturday slammed a Wall Street Journal series of articles about the social media company’s platform as containing “deliberate mischaracterizations” and said the articles “conferred egregiously false motives to Facebook’s leadership and employees.”

The Wall Street Journal, citing a review of internal company documents that included research reports, online employee discussions and drafts of presentations to senior management, said that although Facebook researchers have identified “the platform’s ill effects,” the company failed to fix them.

The Wall Street Journal articles say that Facebook exempted high-profile users from some or all of its rules, played down the negative effects on young users of its Instagram app, made changes to its algorithm that made the platform “angrier,” and had a weak response to alarms raised by employees over how the platform is used in developing countries by human traffickers.

Nick Clegg, Facebook’s vice president of global affairs, writing in a blog post https://about.fb.com/news/2021/09/what-the-wall-street-journal-got-wrong, said the Wall Street Journal’s stories “contained deliberate mischaracterizations of what we are trying to do, and conferred egregiously false motives to Facebook’s leadership and employees.”

Clegg called “just plain false” an allegation that “Facebook conducts research and then systematically and willfully ignores it if the findings are inconvenient for the company.”

Facebook, Clegg said, understands the “significant responsibility that comes with operating a global platform” and takes it seriously, but “we fundamentally reject this mischaracterization of our work and impugning of the company’s motives.”

Clegg defended Facebook’s handling of posts on the COVID-19 vaccine and said that the “intersection between social media and well-being” remains an evolving issue in the research community.

(Reporting by Juby Babu in Bengaluru; Editing by Leslie Adler)

Image Credit: Reuters

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Source: https://datafloq.com/read/facebook-says-wsj-allegations-mischaracterizations-confer-false-motives/17968

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Proximity labeling: an enzymatic tool for spatial biology

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In this Forum, we highlight how cutting-edge, proximity-dependent, enzymatic labeling tools, aided by sequencing technology developments, have enabled the extraction of spatial information of proteomes, transcriptomes, genome organization, and cellular networks. We also discuss the potential applications of proximity labeling in the unexplored field of spatial biology in live systems.

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Source: https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(21)00211-0?rss=yes

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Synthetic biology applications of the yeast mating signal pathway

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Glossary

Central carbon metabolism (CCM)

as the main source of energy, CCM oxidizes carbon through glycolysis, the pentose phosphate pathway, and the tricarboxylic acid cycle.

Chassis

a cell host or an organism for the production of biochemicals such as enzymes by introducing synthetic modules or devices into the cell.

Circuit

an assembly of biological parts that enables cells to perform logical functions, such as genetic switches, oscillators, and logic gates.

Convolutional neural network

a class of artificial neural networks with multiple building blocks that automatically and adaptively learn spatial hierarchies of features through back-propagation.

Clustered regularly interspaced short palindromic repeats (CRISPR)

a genome-editing tool in which CRISPR-associated nuclease 9 (Cas9)–guide RNA (gRNA) complexes recognize a protospacer adjacent motif through base-pairing and then cleave the target DNA,

CRISPR activation or interference (CRISPRa/i)

a tool that uses dead Cas protein and gRNA to activate or repress genes, resulting in gene upregulation or downregulation, respectively.

Cubic ternary complex model

an equilibrium model that describes the interactions between receptor and ligand. This model simulates the interactions of G proteins and receptors in both their active and inactive conformations.

G proteins

heterotrimeric G protein complexes are composed of α, β and γ subunits. Replacement of GDP by GTP in Gα causes a conformational change that dissociates the Gβγ subunits, leading to the activation of downstream signaling.

G protein-coupled receptor (GPCR)

a generic class of versatile, seven transmembrane-domain proteins that regulate a diverse array of intracellular signaling cascades in response to hormones, neurotransmitters, and other stimuli.

Karyogamy

a cascade of molecular events that finally lead to fusion of the nuclei and the formation of diploid cells.

Metabolic engineering

a new scientific field that combines multi-gene recombination technology with metabolic regulation and biochemical engineering to overproduce desired products.

Mitogen-activated protein kinases (MAPKs)

a family of serine/threonine kinases that convert extracellular signals into a diverse range of cellular responses.

Omics

studies include genomics, transcriptomics, proteomics, and metabolomics that characterize and quantify pools of biological molecules, and together give rise to the field of integrative genetics.

Oscillator

a genetic circuit where oscillation is generated by the inhibition and activation of transcriptional/translational feedback loops.

Pheromone-response element (PRE)

a cis element that is present in multiple copies in the promoters of a variety of pheromone-responsive genes; PREs interact with Ste12 to initiate the transcription of pheromone-induced genes.

Quorum sensing

a cell density-dependent phenomenon in which cells adapt their behavior by synthesizing, secreting, perceiving, and reacting to small diffusible signaling molecules termed autoinducers.

Scaffold protein

proteins that recruit other proteins to form a functional unit, thus enhancing signaling efficiency and fidelity.

Ste5ΔN-CTM

a Ste5 mutant that lacks the Gβγ-binding site because its N-terminus has been truncated; Ste5ΔN-CTM is no longer recruited to the plasma membrane following pheromone treatment.

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Biotechnology of functional proteins and peptides for hair cosmetic formulations

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    Source: https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(21)00213-4?rss=yes

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    VW’s 9-month electric vehicle deliveries to China more than triple

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    FRANKFURT (Reuters) – Volkswagen’s deliveries of battery-powered electric vehicles to China more than tripled in the first nine months of the year, the carmaker said on Friday, less than two months after it flagged the need to change its e-car strategy there.

    Deliveries of battery electric vehicles (BEV) to the world’s largest car market stood at 47,200 in the January-September period, up from 15,700 in the same period last year.

    “As planned, we significantly accelerated the BEV market ramp-up in China in the third quarter, and we are on track to meet our target for the year of delivering 80,000 to 100,000 vehicles of the ID. model family,” Christian Dahlheim, head of group sales, said.

    Volkswagen Chief Executive Herbert Diess in July said the carmaker had to change its approach to how it markets its BEVs in China after first-half deliveries stood at just 18,285.

    (Reporting by Christoph Steitz; Editing by Maria Sheahan)

    Image Credit: Reuters

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    Source: https://datafloq.com/read/vws-9-month-electric-vehicle-deliveries-china-triple/18644

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