ARTICLE | Discovery & Translation
BioCentury’s roundup of translational innovation
By Danielle Golovin, Biopharma Analyst
July 29, 2023 1:11 AM UTC
A Stanford University team led by Nathanael Gray and Gerald Crabtree revealed in Nature molecules that recruit cancer driver proteins to the promoters of cell death genes to activate their expression instead, killing the cancer.
Dubbed TCIPs (transcriptional/epigenetic chemical inducers of proximity), the lead molecule, TCIP1, killed four diffuse large B cell lymphoma cell lines. Genes activated by TCIP1 were enriched for known cell-cycle arrest and pro-apoptotic targets normally repressed by BCL6, such as p21, FOXO3 and PMAIP1. In wild-type mice, a once daily intraperitoneal injection of TCIP1 “was well tolerated with no adverse effects noticed and no significant changes in mouse body weight,” the authors wrote…
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- Source: https://www.biocentury.com/article/648744/turning-cancer-drivers-into-cell-death-drivers-plus-lnps-to-edit-stem-cells-and-more
