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Eisai: LENVIMA (lenvatinib) Plus KEYTRUDA (pembrolizumab) Approved in Japan for Radically Unresectable or Metastatic Renal Cell Carcinoma
"Nearly one in three cases of renal cell carcinoma are diagnosed at an advanced stage,(1) and patients are in need of new treatment options that may improve survival outcomes,(2)" said Dr. Gregory Lubiniecki, Vice President, Oncology Clinical Research, Merck & Co., Inc., Kenilworth,
N.J., U.S.A. Research Laboratories. "In the CLEAR/KEYNOTE-581 trial, KEYTRUDA plus LENVIMA reduced the risk of disease progression or death by 61% versus sunitinib, a current standard of care. We are encouraged that patients with certain types of advanced renal cell carcinoma may have the opportunity to benefit from this combination."
"Today's milestone for LENVIMA plus KEYTRUDA as a treatment for radically unresectable or metastatic renal cell carcinoma is particularly exciting as it marks the second approval for the combination in Japan," said Terushige Iike, President of Eisai Japan, Senior Vice President, Eisai. "We are thrilled to be able to provide Japanese patients with a new treatment option, illustrating our shared commitment with Merck & Co., Inc., Kenilworth, N.J., U.S.A. to develop therapies with the aim of addressing the unmet needs of those living with difficult-to-treat cancers. We would like to thank the patients, families and healthcare providers who made this approval possible."
The Japanese package inserts for LENVIMA and KEYTRUDA note that in the CLEAR/KEYNOTE-581 trial, adverse reactions were observed in 341 (96.9%) of 352 patients (including 42 of 42 Japanese patients) in the safety analysis set. The most common adverse reactions included diarrhea in 192 patients (54.5%), hypertension in 184 patients (52.3%), hypothyroidism in 150 patients (42.6%), decreased appetite in 123 patients (34.9%), fatigue in 113 patients (32.1%), stomatitis in 113 patients (32.1%), palmar-plantar erythrodysesthesia syndrome in 99 patients (28.1%), proteinuria in 97 patients (27.6%), nausea in 94 patients (26.7%), dysphonia in 87 patients (24.7%), rash in 77 patients (21.9%), and asthenia in 71 patients (20.2%).
Renal cell carcinoma is the most common type of kidney cancer worldwide; about nine out of 10 kidney cancer diagnoses are RCC.(3) In Japan, there were more than 25,000 new cases of kidney cancer diagnosed and more than 8,000 deaths from the disease in 2020.(4) Approximately 30% of patients with RCC will have metastatic disease at diagnosis.(5) Survival is highly dependent on the stage at diagnosis, and with a five-year survival rate of 14% for patients diagnosed with metastatic disease, the prognosis for these patients is poor.(6)
Eisai and Merck & Co., Inc., Kenilworth, N.J., U.S.A. continue to study the LENVIMA plus KEYTRUDA combination across several types of cancer with more than 20 clinical trials.
For more information, visit https://www.eisai.com/news/2022/pdf/enews202214pdf.pdf.
Copyright 2022 JCN Newswire. All rights reserved. www.jcnnewswire.comEisai and Merck & Co., Inc., Kenilworth, N.J., U.S.A. (known as MSD outside the United States and Canada) today announced that the Japanese Ministry of Health, Labour and Welfare (MHLW) has approved the combination of LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, plus KEYTRUDA.
Transmit Entertainment 2021/22 Interim Results Achieve Turnaround, Revenue More Than Doubled to HK$587 million
During the Review Period, the Group further advanced the "Stay-at-Home Economy" and its development strategy of brand diversification. Mainland China continued to be the major source of the Group's revenue and business growth. The Group's proportion of revenue from Mainland China recorded a year-on-year increase of 17.7 percentage points to approximately 96.8%. The Group recorded outstanding results during the Review Period, amounting to approximately HK$587.2 million, representing an increase of approximately 265.2% as compared to the corresponding period last year. The Group's turnaround was mainly due to the airing of "The Ideal City", an inspiring urban workplace TV series and "The Detectives' Adventures", a megahit mystery solving reality show, which drove a significant year-on-year revenue growth of approximately 1,296.4% to approximately HK$502.2 million for the film, TV series and variety show production and distribution segment; and the Group completed the disposal of partial equity interests in the film exhibition business in May 2021, which reduced both the sales and distribution expenses of the related film exhibition business. During the Review Period, the Group recorded the profit attributable to the owners of the Company of approximately HK$10.6 million.
Business Review
Keeping up with the development of the industry and the entertainment tastes of young viewers, the Group has continued to focus on developing and producing contents of outstanding film, TV series and variety show, while actively exploring innovative business models such as web series, online movies and short videos. "The Ideal City" aired on the video website iQIYI and numerous first-tier TV stations across the country, ranking first in the CSM63 TV series viewership ranking, as well as receiving more than ten industry honors and awards including being shortlisted for the 2018-2022 List of Key TV Series Planning and Theme of the National Radio and Television Administration, and was recognized as the "2021 Outstanding Show Broadcasting Overseas" by the National Radio and Television Administration. "The Detectives' Adventures" creatively reinterprets a classic film and television copyright through live action role playing, introducing a production model for detective-themed variety show that appeals to audiences of all ages, successfully gaining multiple industry awards, including the 2021 Internet Viewing + Ranking Internet Varity Show of the Year and the Innovative Variety Show of the Year of the Sixth New Recreation . New Consumption etc. On the other hand, the scriptwriting team of the Group participated in popular TV shows such as the Lantern Festival Gala of the China Media Group and the variety show "Super Sketch Show", continuously spurring related discussions and becoming a trending topic in multiple platforms.
Considering that the COVID-19 pandemic has brought about a challenging business environment for the film exhibition business, the Group disposed partial equity interests in the film exhibition business to reallocate financial resources to other businesses with higher development potential, thereby generating more returns for shareholders of the Company (the "Shareholders"). The disposal transaction was completed on 26 May 2021. Thereafter, in accordance with a management agreement and a supplemental agreement entered by the Group with Cinema City (WL) Limited and Mandarin Motion Pictures Limited, the Group earns fees for the operation of Langham Place Cinema during the term of the agreements. The management believes that the above-mentioned strategic measures will proactively pose a positive impact on the Group's future results and financial performance.
The Group continued to improve its industry chain and broaden its revenue base, and its artistes and internet celebrities continued to be more influential in market segments. During the Review Period, the Group's artistes starred in many TV series and movies, and participated in many endorsement activities. Among which, Yang Chaoyue starred in two costume TV dramas "Chongzi" and "The Seventh Generation", and Li Yitong starred in TV series such as "Warm Cold Nights In The Nine Heavens", "Spy Game" and "Punch Out".
Outlook
Looking forward, the Group will continue to focus on the development of film and TV series production business as well as artiste and internet celebrity agency business in Mainland China, and strives to create a pan entertainment ecosystem and integrate upstream and downstream industry chains, while proactively expanding various realization channels from the downstream industry chains in a bid to attain the strategic deployment of fusing its strengths and resources. Taking advantages of the ample resources of online platforms, the Group will continue to focus on producing quality film and TV series content, while actively diversify the revenue base by continuously identifying business opportunities in relation to the "Stay-at-Home economy" on four aspects including online stream, short videos, internet celebrity cultivation and traffic monetization.
The Group is currently producing a number of projects, including an urban mystery TV series "Frozen Surface" and the third season of variety show "I Love You, Me Too". With the good viewing performance and online popularity of the work, the Group plans to create a self-developed multi-season variety show brand by producing the third season of "I Love You, Me Too" and the second season of "The Detectives' Adventures". In addition, the Group will develop and produce films and TV series on a number of popular copyrighted works of fiction including "Love Destiny", "Wishful Egg", "Romance in the City", "Peach Blossom Debt", "Queen of the Sea" and "Locard's Theory".
Ms. Zhao Wen Zhu, President and Executive Director of Transmit Entertainment, said, "Although the industry was still plagued by the COVID-19 pandemic and the market sentiment, the Group realized a turnaround during the Review Period, benefited from tapping the 'Stay-at-Home Economy' and brand diversification development strategies. Significant growth from the segment of TV series and variety shows production fully demonstrated the outstanding competitiveness of our production team, which helps the Group proactively seize enormous business opportunities in the China market and continue to drive business growth. Transmit Entertainment will further utilize its whole industry chain capabilities to continuously enhance its profitability and extend our competitive edges in the industry, and generate sustainable and satisfactory returns to our shareholders."
About Transmit Entertainment Limited (stock code: 1326)
Transmit Entertainment Limited is a fully-integrated media and entertainment company that empowers the consumer industry. It principally engages in (i) film, TV series and variety show production and distribution; (ii) film exhibition; and (iii) pan-entertainment (including internet celebrities and artiste agency, and pan-entertainment businesses along the value chain). The Group strives to implement the development strategy in relation to the stay-at-home economy and brand diversity through combining resources of scriptwriting, d irection and celebrity to cultivate, explore and create popular films and television copyrights by continuously offering quality content and nurturing talented artistes in order to develop its self-owned full industry chain model and construct a unique soft-power moat.
Taking advantages of online platforms to cultivate new artistes and celebrities, the Group proactively explores and develops self-owned retail brand targeting young consumers to further diversify the revenue base by identifying business opportunities in relation to the stay-at-home economy on four aspects, including online stream, short videos, celebrity cultivation and traffic monetization, which eventually forms a business model with the Group being the center supported by film, television and variety show. The Group also expands its business through partnership and enriches its industry chain with self-developed products, forming an integrated upstream and downstream industry chain to fully seize the new opportunities arising from the pan-entertainment business.
Copyright 2022 ACN Newswire. All rights reserved. www.acnnewswire.comTransmit Entertainment Limited ("Transmit Entertainment" or the "Company", together with its subsidiaries, the "Group"; stock code: 1326) today announced its unaudited interim results for the six months ended 31 December 2021 (the "Review Period").
Hektar REIT 2021 Performance: Weathering the Challenges
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For the fourth quarter ended 31 December 2021 ("4Q 2021"), Hektar REIT recorded revenue of RM24.98 million, which is 16.2% lower compared to the same quarter of the preceding year. Property Operating Expenses reduced by RM4.86 million or savings of 27.9% compared to the same quarter in the previous year. Hektar REIT registered net property income of RM12.38 million for the quarter under review, which is a slight increase of 0.2% compared to the corresponding quarter of the previous year, while realised income for 4Q 2021 was 185.5% higher at RM3.21 million compared to the RM1.12 million recorded in 4Q 2020.
The Manager noted that there are signs of recovery supported by the gradual reopening of the economy and it can also be seen in the steady rise in visitor footfall since the relaxation of restrictions by the Government. While Hektar REIT is cognisant of the economy's improved growth trajectory supported by a recovering labour market, continued policy support and expansion in external demand, as well as the possible opening of international borders as early as the second quarter, the REIT is nevertheless retaining its cautious outlook in the face of the current wave of infections stemming from the Omicron strain.
Income Distribution
As earlier announced, Hektar REIT declared an income distribution of RM11.9 million for 4Q 2021, equivalent to 2.53 sen per unit or a DPU yield of 4.96%, which is 181% higher compared to the income distribution for the corresponding period in 2020. The COVID-19 pandemic has impacted the retail industry significantly and the REIT has also not been spared. However, we remain committed to steering our portfolio into recovery this year, barring any unforeseen circumstances despite future Variants of Concern ("VOC") that might disrupt the overall recovery of the retail & economic sector.
Private Placement
During the quarter under review, Hektar REIT's fund size increased to 471,260,178 units from 461,960,178 units arising from the private placement exercise announced on 15 November 2021. A total of 9.30 million units out of the total proposed private placement of 23.098 million units were subsequently placed out in two tranches in December 2021, raising RM4.23 million. The private placement was undertaken to raise funding for working capital and capital work in progress, facilitating Hektar REIT's day-to-day operations as a whole by providing more flexibility in terms of cash flow management.
Sustainability Efforts
Hektar REIT remains committed to fulfill its obligation to ensure that all business activities are performed to high standards of Environmental, Social and Governance (ESG). Various energy utilisation and optimisation initiatives since 2017 have been put in place for all of its shopping malls, resulting in a significant reduction in greenhouse gas emissions (recorded as CO2e) and energy usage over the last five years. Despite the pandemic, reducing the environmental footprint of our assets and operations remain a priority. We managed to reduce the overall amount of CO2e emissions of our assets by about 11.6% to 18.8 million kgCO2e in 2021 from almost 21.3 million kgCO2e in 2020. Emissions intensity of our assets expressed as the amount of CO2e emitted per gross floor area (kgCO2e/sq.ft.) also improved to 4.0 kgCO2e/sq.ft. from 4.50 kgCO2e/sq.ft. in 2020. Overall, the portfolio's Building Energy Intensity ("BEI") is also on a declining trend. Hektar REIT is a constituent member of the FTSE4Good Bursa Malaysia Index and in its latest December 2021 evaluation, its ESG conduct has been recognised with a 3-star ESG rating by FTSE Russell.
For further information, please log on to www.bursamalaysia.com.
Copyright 2022 ACN Newswire. All rights reserved. www.acnnewswire.comHektar Asset Management Sdn. Bhd., the Manager of Hektar Real Estate Investment Trust ("Hektar REIT"), today announced Hektar REIT's annual results for the financial year ended 31 December 2021 ("FY2021") with revenue at RM96.60 million in FY2021, down by 13.1% compared to the same period in the preceding year.
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