Chimeric antigen receptor (CAR) T cells have revolutionized cancer treatment. CARs use antibody-derived binding domains to redirect T cells to antigens expressed on the surface of cancer cells. However, the high affinity of most currently used CAR-binding domains results in excessive T-cell activation limiting CAR T-cell persistence and the inability to differentiate between antigen-high tumor cells and antigen-low healthy cells. We review recent data on the use of low-affinity CAR-binding domains and evaluate technologies and approaches to engineer and screen low-affinity antibody variants for CAR T-cell development.

Check out our review of Mushroom Wars 2

The post Mushroom Wars 2 Review (PS5, PS4) – Love These Shrooms appeared first on PlayStation LifeStyle.

Set to take off in April, Canadian ultra-low-cost carrier Lynx Air has put its initial routes on sale.…

20 January 2022 by Todd A. Gray , Joseph Fiorello and Sean Wood Lewis Brisbois Bisgaard & Smith LLP (January 2022) – The CDC recently issued guidance to businesses developing marijuana policies, balancing state legalization efforts and fleet safety. Per the CDC, marijuana should be addressed in motor vehicle safety programs. Marijuana is a particularly challenging issue as THC can remain […]

Expats and rental portfolios go together like peanut butter and jelly. It’s no surprise that a fair amount of retired globetrotters owe their freedom to real estate investing. While many […]

WTL Winter comes to a three-day conclusion with Team NV, Shopify Rebellion, DPG, Alpha X, KaiZi Gaming, Team Liquid, and Kwangdong Freecs vying for the ultimate team championship in StarCraft II.

Organizations should balance process automation and human interaction to meet their unique security requirements.

The Federal Reserve issued its long-awaited report on the status of its research on whether the U.S. should issue a digital currency. It isn’t a story that makes for exciting headlines, but it’s all good: The Fed released the report, it’s designed to create discussion, and any decision will rest with Congress. American Banker headlined its report, “Fed defers to elected officials on issuing digital currency.” The Independent Community Bankers of America (ICBA) lauded the Fed’s stance, saying, “The Fed’s discussion paper rightly acknowledges many important policy considerations, such as preserving private-sector intermediaries, balancing consumer privacy with transparency, ensuring transferability

The post Fed Releases Digital Assets Report first appeared on FinTech Rising.

Call of Duty Vanguard and Warzone Pacific Season 2 has been delayed, Activision has officially confirmed. The new start date for S2 has been pushed back to February 14, 2022. This push back to Valentine’s Day is in response to major issues across Call of Duty Vanguard, Warzone Pacific, and Modern Warfare, with developers working on updates for each game. “We will use this additional development time to deliver updates, including optimizations to gameplay,” reads the latest community blog. This will include weapon balancing for a fairer playing field, as well as important bugs fixes and stability improvements. Activision reminds players that these updates are being rolled out across multiple games, spanning a whole host of platforms, and two console generations. While some will see the Vanguard and Warzone Pacific Season 2 delay as a disappointment, others agree that it’s the best decision. In recent weeks there have been a growing number of reports of frustrating bugs and performance issues – it doesn’t make sense for Call of Duty to go live with its first major content drop of 2022 without some crucial clean-up work first. It’s a strange time for the power-selling first person shooter series. Developer Sledgehammer Games wasn’t able to capitalise on the franchise’s momentum with last year’s Call of Duty Vanguard. At least in terms of sales, prompting speculation that this year’s entry could release a little sooner in the year. Then, of course, there’s Microsoft’s acquisition of publisher Activision. Nothing’s been set in stone though there’s a chance we could see Call of Duty become an Xbox exclusive from 2023 onwards, a landmark shift for the genre and industry at large. In our review we scored Vanguard a mighty 9/10 for its cinematic story campaign, sharp multiplayer, and reworked Zombies: The stars have aligned for Call of Duty: Vanguard. For the first time, this truly feels like a full package without any caveats. Sure, some parts are naturally stronger than others but there isn’t a weak link in sight. After back to back triumphs, Call of Duty is now on a killstreak. Source: Call of Duty

The U.S. Federal Reserve has issued a discussion paper today on central bank digital currencies (CBDCs). The paper is meant to serve as the first step in a public discussion about CBDCs between the Federal Reserve and stakeholders. The documentation offers a basic background on what CBDCs are and how they may impact citizens. As Read more...

The post What The U.S. Federal Reserve Omits in its CBDC Paper appeared first on Finovate.

Call of Duty: Warzone Pacific and Vanguard season 2 has officially been delayed by almost two weeks as developers need more time to work on fixes and updates.

A Call of Duty Community Update on the Call of Duty Blog describes Activision's "ongoing commitment to improving your gameplay experience." This includes the...