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Four Seasons Unveils Additional 2022 Itineraries Aboard the Four Seasons Private Jet Including a New ‘Uncharted Discovery’ Journey to Explore Antarctica, Machu Picchu and More



“Late last year, we announced three awe-inspiring 2022 itineraries aboard the new Four Seasons Private Jet. The response was overwhelming, with record sellouts and extensive waitlists, signaling considerable pent up demand for travel,” says Christian Clerc, President, Global Operations for Four Seasons Hotels and Resorts. “Now, more than ever, guests are planning bucket-list trips to far corners of the world to make up for lost time. To meet this demand, we’ve introduced two additional opportunities to explore new and remote destinations with legendary Four Seasons service in the sky.”

Clerc continues, “Equally as important as the incredible destinations and experiences, we know that travellers are looking for a seamless service experience where their health and safety is a priority. The Four Seasons Private Jet offers the best of both worlds. From takeoff to landing and at every destination in between, we adhere to the highest standards of health and safety, allowing guests to embrace the wonders of travel in a truly unique way with the utmost comfort and peace of mind.”

A truly one-of-a-kind adventure, the expertly curated itineraries available as part of the Four Seasons Private Jet experience allow passengers to seamlessly cross off a collection of bucket list destinations, leaving the stress of multiple commercial flights, layovers and delays behind.

Introducing Uncharted Discovery, An All-New 21-Day Expedition Featuring Seven Captivating Destinations

Uncharted Discovery – November 28 to December 18, 2022 – New Orleans, USA Peninsula Papagayo, Costa Rica  Machu Picchu, Peru  Buenos Aires, Argentina Antarctica – Bogotá, Colombia – Paradise Island, Bahamas 

The journey begins in the Big Easy, where guests will enjoy welcome cocktails and dinner at the upcoming Four Seasons Hotel New Orleans, a five-star oasis on the banks of the Mississippi River. Early arrivals can explore the one-of-a-kind city renowned for its live jazz scene, spicy Creole cuisine and colourful festivals. Next stop is the serene paradise of golden shores and tropical jungles in Costa Rica. Travellers can experience Peninsula Papagayo’s lush scenery on a thrilling zip line circuit, play a round on the Arnold Palmer-designed championship golf course, or gaze at stars in the southern sky through a powerful GPS-guided telescope while enjoying cocktails and treats infused with meteorite dust at Four Seasons Resort Costa Rica at Peninsula Papagayo.

From Costa Rica, guests will venture into the Peruvian Highlands to Cusco and the Sacred Valley of the Incas, boarding a privately chartered train to the UNESCO World Heritage site of Machu Picchu, an astonishing testament to the might of the Inca Empire. Travellers can visit the historic city of Cusco, offering a wealth of archaeological ruins and Spanish colonial architecture to discover. In Argentina, guests will stay at Four Seasons Hotel Buenos Aires, enjoying a day trip to Iguazú Falls, one of nature’s most magnificent spectacles, named for the place where the Iguazú River plunges over a lava cliff into 275 interlinking waterfalls. Music lovers can take a private behind-the-scenes tour of Buenos Aires’ magnificent opera house, acoustically considered to be one of the five best concert venues in the world.

For the first time ever, the Four Seasons Private Jet will then deliver guests to the Earth’s southernmost continent, Antarctica. Guests will fly over the infamous Drake Passage by charter plane, landing at King George Island before boarding a luxurious polar ship for four nights as they embark on an unforgettable expedition to the seventh continent. While enjoying seamless Four Seasons service in one of the most remote locations on Earth, daily excursions will allow guests to observe incredible wildlife and enjoy scenery of iceberg-dotted bays, brilliant blue glaciers and snow-blanketed landscapes.

Then, in Colombia’s lively capital city, a local artist will guide guests through traditional galleries, open-air displays and neighbourhoods splashed with vibrant street art before a private concert from the world-renowned Bogotá Philharmonic, Colombia’s national symphony orchestra. Four Seasons Hotel Bogota offers a welcome home base in the energetic Zona Rosa, where the city comes alive with high-end boutiques and popular restaurants. Legendary Caribbean hideaway The Ocean Club, A Four Seasons Resort, Bahamas is the final stop of an unforgettable journey. Guests will enjoy soaking in the sun-drenched beauty of the Bahamas, lounging on the pristine private white-sand beach, or a relaxing treatment at the private Balinese-style spa for before a final farewell dinner.

Back by Popular Demand: World of Adventures, a Trailblazing Voyage Across Four Continents

World of Adventures 2022 – May 3 to 26, 2022Seattle, USA – Kyoto, JapanBali, IndonesiaSeychellesRwanda – Marrakech, Morocco – Bogotá, Colombia – Galápagos Islands – Miami, USA

A proven favourite expedition, World of Adventures is back in 2022, offering a tour of eight countries over 24 days for an around-the-world journey like no other. In Seychelles, an expert yogi will guide guests in an evening mediation with a stunning view of the sunset over Petite Anse Bay as the backdrop. In Rwanda, a hike through the lush bamboo forests of Volcanoes National Park offers the chance to witness mountain gorillas in their natural habitat. In the Galápagos Islands, guests will spend three unforgettable nights aboard a private ship to explore the unique archipelago. In Japan, travellers can explore Kyoto’s tranquil temples, colourful shrines and exquisite gardens, while in Marrakech, a myriad sights, sounds and flavours are on offer.

Both Uncharted Discovery and World of Adventures 2022 journeys are complement to three sold out Private Jet itineraries including African Wonders, a 13-day family friendly journey designed for travellers of all ages, Timeless Encounters, a 24-day itinerary exploring vibrant city centres and tranquil islands, and Ancient Explorer, a 24-day around the world journey.

The Reimagined Four Seasons Private Jet

All 2022 itineraries will take place aboard the new Four Seasons Private Jet, an enhanced, enriching and interactive flight experience with meticulous construction and thoughtful Four Seasons design. The new Airbus A321neo-LR aircraft has been fully customised to Four Seasons exacting specifications, with input from previous journey passengers. Offering the widest and tallest cabin in its class, the 48-seat interior has been configured for even greater comfort with as much space as possible for guests to spread out and makes themselves at home.

Anticipating every detail, the Guest Relations team works closely with each passenger from initial inquiry until their safe return home. On board the Four Seasons Private Jet, an experienced flight crew includes a dedicated Concierge, Executive Chef and Journey Physician. While visiting remote destinations, guests will stay at luxury accommodations selected by the Four Seasons team.

Safety First

As conditions continue to evolve, guests can take comfort in the peace of mind that comes with travelling with Four Seasons. In partnership with TCS World Travel and in adherence with Four Seasons on-the-ground enhanced global health and safety program Lead With Care, in place at all hotels, resorts and residences worldwide, Four Seasons works closely with leading global experts and local authorities to protect the health and safety of every Four Seasons guest and employee. This will include medical pre-screening of each passenger, Four Seasons employee and flight crew member prior to embarking on each itinerary, with a Journey Physician accompanying guests throughout the trip.

Booking Information

Travellers interested in booking the luxury adventure of a lifetime are invited to click here for a closer look at the exclusive journeys on offer in some of the world’s most captivating destinations.

Guests who book a Four Seasons Private Jet journey can take advantage of flexible cancellation options. * Conditions apply – for details, inquire here – [email protected].

About the Four Seasons Private Jet Experience

Learn more about the Four Seasons Private Jet Experience and follow the #FSJet hashtag on Twitter and Instagram for the latest news and to continue exploring the Four Seasons Private Jet.

The Four Seasons Private Jet is operated by TCS World Travel, dedicated to delivering immersive, worry-free travel experiences for the globally curious and modern luxury traveller. For more information from the industry leader in private jet journeys, click here.

About Four Seasons Hotels and Resorts

Founded in 1960, Four Seasons Hotels and Resorts is dedicated to perfecting the travel experience through continual innovation and the highest standards of hospitality. Currently operating 119 hotels and resorts, and 44 residential properties in major city centres and resort destinations in 47 countries, and with more than 50 projects under planning or development, Four Seasons consistently ranks among the world’s best hotels and most prestigious brands in reader polls, traveller reviews and industry awards. For more information and reservations, visit For the latest news, visit and follow @FourSeasonsPR on Twitter.

Media Contact:
Matthew Levison 
[email protected]

SOURCE Four Seasons Hotels and Resorts

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PR Newswire

Perfect World to pioneer digital culture and creative sector in joint hands with partners



As a world’s leading entertainment group, Perfect World proposed “Creative Thinking” strategy, aiming at breaking the barrier of the real world and virtual world, and combining new types of games with traditional industries so as to empower the development of traditional industries and promote digital upgrade of traditional industries as well.

Under the “Creative Thinking” strategy, Perfect World has made significant achievements in its cooperation with enterprises and institutions, such as implanting scenes of the Qinhuai Lantern Fair of Nanjing Confucius Temple into its famous game “Zhuxian,” and the collaboration between its mobile game Chronicle of Infinity and the famous sports brand Peak.

Perfect World CEO Dr. Robert H. Xiao said at the conference that after all the successful cases, Perfect World has been more confident about cross-over cooperation between digital culture industry and traditional industries. He promised that Perfect World will keep exploring to establish a value chain that empowers traditional industries, and incubate more new types of culture content, products, and business models.

In its collaboration with Nianhuawan scenic spot in Wuxi, Perfect World gamified the scenic spots, and brought tourists an immersive experience by combing the scenic spot and the digital world. The move helps the scenic spot to upgrade from service-based economic to experience economy.

“Not only will we explore subdivided fields with partners, but also work as a bridge to promote cross-over cooperation among companies in various fields, so as to achieve common development,” said Dr. Xiao. “And we hope to joint hands with our partners to unlock a new track in this ‘experimental production’ of the culture industry that faces the future,” he added.

Perfect World will tailor a whole set of solutions and plans on digital upgrading partners’ products based on their requirements. For example, in its cooperation with Shanghai Science and Technology Museum, Perfect World will develop a game to turn the complicated scientific knowledge into visions to help readers understand the scientific knowledge. The Group will also have an in-depth cooperation with China Audio-video and Digital Publishing Association in the field of education and vocational training such as e-sports talent cultivation.

The culture department of Beijing’s Dongcheng district, People’s Cultural Tourism of People’s Daily, a cultural & creative institute affiliated to Tsinghua University, Beijing Dongsheng Bozhan Cloud Computing Technology Co., Ltd., and Nianhuawan scenic spot, also signed strategic cooperation agreements with Perfect World in the brand cooperation conference.

SOURCE Perfect World

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European Hematology Association : la réponse humorale au vaccin Pfizer/BioNTech BNT162b2 est altérée chez les patients recevant un CAR-T ou un traitement immunosuppresseur de haute intensité



LA HAYE, Pays-Bas, 12 juin 2021 /PRNewswire/ — Le vaccin Pfizer/BioNTech BNT162b2 a été approuvé pour la prévention de l’infection par le coronavirus 2 du syndrome respiratoire aigu sévère (SRAS-CoV-2) et est recommandé pour les patients immunodéprimés. Cependant, son efficacité et son innocuité chez les patients suivant une thérapie cellulaire immunologique n’ont pas été bien documentées. Dans le cadre de cette étude, nous avons évalué l’efficacité et l’innocuité du vaccin BNT162b2 chez les patients ayant subi une greffe de cellules hématopoïétiques (HCT) et un traitement au récepteur d’antigène chimérique (CAR)-T. Nous avons suivi prospectivement 79 patients vaccinés ayant été activement traités au Centre médical Sourasky de Tel Aviv et surveillé le profil d’innocuité et la réponse immunitaire humorale au vaccin.

Dans l’ensemble, le vaccin a été bien toléré et tous les effets indésirables se sont résorbés en quelques jours, à l’exception d’un rejet de greffe secondaire, qui fait toujours l’objet d’une enquête. Nous avons observé que seulement 36 % des patients ayant reçu un traitement CAR-T ont développé une réponse aux anticorps humoraux comparativement à 81 % des patients ayant subi une TSS allogénique. De plus, les patients atteints d’aplasie des cellules B et ceux ayant reçu le vaccin peu après la perfusion de cellules étaient moins susceptibles de développer des anticorps. Prises ensemble, ces données démontrent que la réponse humorale au vaccin BNT162b2 est significativement altérée chez les patients recevant le CAR-T, par opposition à ceux ayant reçu une TSS allogénique ayant une bonne réponse.

Présentateur : Professeur Ron Ram

Affiliation : Unité BMT, Tel Aviv Sourasky Medical Center, Tel Aviv, Israël


À propos du congrès annuel de l’AEH : Chaque année, en juin, l’AEH organise son congrès annuel dans une grande ville européenne. Cette année, en raison de la persistance de la pandémie de COVID-19, l’AEH organise pour la deuxième fois un Congrès virtuel. Le Congrès s’adresse aux professionnels de santé travaillant dans le domaine de l’hématologie ou s’y intéressant. Les sujets du programme scientifique vont de la physiologie et du développement des cellules souches à la leucémie, le lymphome, le diagnostic et le traitement, les globules rouges, les globules blancs et les troubles plaquettaires, l’hémophilie et le myélome, la thrombose et les troubles de la coagulation ainsi que la transfusion et la transplantation de cellules souches.

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SOURCE European Hematology Association (EHA)

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EHA:Eficacia de la vacuna Pfizer/BioNTech BNT162b2 en pacientes que reciben CAR-T



– European Hematology Association:La respuesta humoral a la vacuna Pfizer/BioNTech BNT162b2 se ve afectada en pacientes que reciben CAR-T o terapia inmunosupresora de alta intensidad

LA HAYA, Países Bajos, 12 de junio de 2021 /PRNewswire/ — La vacuna Pfizer/BioNTech BNT162b2 ha sido aprobada para la prevención del síndrome respiratorio agudo severo por coronavirus 2 (SARS-CoV-2) y se recomienda para pacientes inmunosuprimidos. Sin embargo, su eficacia y seguridad en pacientes sometidos a terapia celular inmunológica no han sido bien documentadas. En este estudio, evaluamos la eficacia y seguridad de la vacuna BNT162b2 en pacientes que se sometieron a trasplante de células hematopoyéticas (HCT) y terapia con receptor de antígeno quimérico (CAR) -T. Seguimos prospectivamente a 79 pacientes vacunados que fueron tratados activamente en el Centro Médico Sourasky de Tel Aviv y monitoreamos el perfil de seguridad y la respuesta inmune humoral a la vacuna.

En general, la vacuna fue bien tolerada y todos los efectos secundarios se resolvieron en unos pocos días, excepto un rechazo secundario del injerto, que aún está bajo investigación. Observamos que solo el 36% de los pacientes que recibieron terapia CAR-T desarrollaron una respuesta humoral de anticuerpos en comparación con el 81% de los pacientes que se sometieron a un HCT alogénico. Además, los pacientes con aplasia de células B y los que recibieron la vacuna poco después de la infusión de células tenían menos probabilidades de desarrollar anticuerpos. Tomados en conjunto, estos datos demuestran que la respuesta humoral a la vacuna BNT162b2 está significativamente alterada en los pacientes que reciben CAR-T, a diferencia de aquellos después de un HCT alogénico que tuvieron una buena respuesta.

Presentador:  Profesor Ron Ram

Afiliación:  BMT Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel


Acerca del Congreso anual de EHA: Cada junio, la EHA organiza su Congreso Anual en una de las principales ciudades europeas. Este año, debido a la persistente pandemia de COVID19, EHA organiza un Congreso virtual por segunda vez. El Congreso está dirigido a profesionales de la salud que trabajen o estén interesados en el campo de la hematología. Los temas del programa científico van desde la fisiología y el desarrollo de las células madre hasta la leucemia; linfoma diagnostico y tratamiento; las células rojas de la sangre; trastornos de los glóbulos blancos y las plaquetas; hemofilia y mieloma; trombosis y trastornos hemorrágicos; así como transfusión y trasplante de células madre.

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SOURCE European Hematology Association (EHA)

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European Hematology Association: Overall Survival Benefit Established With Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) in Elderly Patients with Transplant-ineligible Newly Diagnosed Multiple Myeloma (NDMM): Long-Term Interim Analysis of the MAIA Study



THE HAGUE, Netherlands, June 12, 2021 /PRNewswire/ — The phase 3 MAIA study evaluated D-Rd versus Rd in 737 patients who were ineligible for high-dose chemotherapy and autologous stem cell transplantation. The primary analysis of MAIA demonstrated a 44% reduction in the risk of disease progression or death after treatment with D-Rd compared with Rd alone. At a median follow-up of almost 5 years (56.2 months), we now report the pre-specified interim overall survival analysis of MAIA.

The addition of daratumumab to Rd treatment significantly reduced the risk of death by 32% (hazard ratio, 0.68; 95% confidence interval [CI], 0.53-0.86; P=0.0013) with an estimated 5-year overall survival rate of 66.3% in the D-Rd group compared with 53.1% in the Rd alone group. These results are despite 46% of patients who received subsequent therapy in the Rd arm receiving daratumumab. Similarly, the significant progression-free survival benefit of D-Rd versus Rd that was identified in the primary analysis was maintained, with a 47% reduction in the risk of disease progression or death (HR, 0.53; 95% CI, 0.43-0.66; P<0.0001) and an estimated 60-month progression-free survival rate of 52.5% versus 28.7%, respectively; these data provide a new PFS benchmark for patients with NDMM who are transplant ineligible. The high overall response rate (93% vs 82%) further demonstrated the added clinical benefit of D-Rd versus Rd alone. No new safety concerns were identified for D-Rd and the most common (>15%) grade 3/4 treatment-emergent adverse events for D-Rd and Rd were neutropenia (54% vs 37%), pneumonia (19% vs 11%), anemia (17% vs 22%), and lymphopenia (16% and 11%). In conclusion, the clinical benefit from the primary analysis of the MAIA study was maintained through 5 years of follow-up and the benefit of upfront D-Rd given to progression was confirmed with a significant OS improvement, further supporting the use of frontline daratumumab as a new standard of care for patients with transplant-ineligible NDMM.

The results of this study will be presented by Prof. Thierry Facon on Saturday, June 12.

Presenter: Professor Thierry Facon

Affiliation: University of Lille, CHU Lille, Service des Maladies du Sang, Lille, France


About the EHA Annual Congress: Every year in June, EHA organizes its Annual Congress in a major European city. This year due to the persisting COVID19 pandemic, EHA organized a Virtual Congress for the second time. The Congress is aimed at health professionals working in or interested in the field of hematology.


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SOURCE European Hematology Association (EHA)

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