Image by Editor The community known as Kaggle is the go-to platform for machine learning data science buffs who want to collaborate with like-minded...
Company adds experienced clinical development expert to its board of directors OSLO, Norway–(BUSINESS WIRE)–Oncoinvent AS announces that Adrian Senderowicz was elected as a Non-executive Director today at the Company’s Extraordinary General Meeting. Adrian Senderowicz is a US Board certified medical oncologist, and President of Oncology Drug Development, LLC. Adrian is a highly experienced and talented […]
Chimeric antigen receptor (CAR) T cells have revolutionized cancer treatment. CARs use antibody-derived binding domains to redirect T cells to antigens expressed on the surface of cancer cells. However, the high affinity of most currently used CAR-binding domains results in excessive T-cell activation limiting CAR T-cell persistence and the inability to differentiate between antigen-high tumor cells and antigen-low healthy cells. We review recent data on the use of low-affinity CAR-binding domains and evaluate technologies and approaches to engineer and screen low-affinity antibody variants for CAR T-cell development.
Almost 40% of people will receive a cancer diagnosis at some point during their lives, according to the National Cancer Institute. This statistic makes it obvious why governments, universities, and...