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Synthetic gene circuits as tools for drug discovery

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Within mammalian systems, there exists enormous opportunity to use synthetic gene circuits to enhance phenotype-based drug discovery, to map the molecular origins of disease, and to validate therapeutics in complex cellular systems. While drug discovery has relied on marker staining and high-content imaging in cell-based assays, synthetic gene circuits expand the potential for precision and speed. Here we present a vision of how circuits can improve the speed and accuracy of drug discovery by enhancing the efficiency of hit triage, capturing disease-relevant dynamics in cell-based assays, and simplifying validation and readouts from organoids and microphysiological systems (MPS).
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Source: https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(21)00137-2?rss=yes

Big Data

China defends clampdown on tech firms in a meeting with Wall St execs – Bloomberg News

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(Reuters) – China’s top securities regulator defended their crackdown on various industries in a private meeting with Wall Street executives, Bloomberg News reported on Saturday.

Investors’ concerns over the regulatory crackdown has led to sharp sell-offs on China’s share markets, reducing the market capitalisation of some of its largest companies including Alibaba Group Holding Limited.

China Securities Regulatory Commission (CSRC) Vice Chairman Fang Xinghai explained during the meeting that recent actions were taken to strengthen regulations for companies with consumer-facing platforms, and improve data privacy and national security, the report https://bloom.bg/39iLhKH said, citing people familiar with the matter.

The three-hour meeting of the China-U.S. Financial Roundtable on Thursday included the head of the People’s Bank of China, and executives from Goldman Sachs Group Inc , Citadel and other Wall Street powerhouses, Bloomberg reported.

The CSRC could not be immediately reached for a comment.

Goldman Sachs declined to comment while Citadel did not immediately respond to a request for comment.

Global investors have been spooked in recent months by a flurry of Chinese regulations targeting sectors ranging from technology, gaming and private tutoring.

Fang said the regulator’s actions in the education and gaming sectors were aimed at reducing anxiety in society, according to the report.

(Reporting by Aishwarya Nair in Bengaluru; Editing by Simon Cameron-Moore)

Image Credit: Reuters

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Source: https://datafloq.com/read/china-defends-clampdown-tech-firms-meeting-wall-st-execs-bloomberg-news/17969

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Big Data

China defends clampdown on tech firms in a meeting with Wall St execs – Bloomberg News

Published

on

(Reuters) – China’s top securities regulator defended their crackdown on various industries in a private meeting with Wall Street executives, Bloomberg News reported on Saturday.

Investors’ concerns over the regulatory crackdown has led to sharp sell-offs on China’s share markets, reducing the market capitalisation of some of its largest companies including Alibaba Group Holding Limited.

China Securities Regulatory Commission (CSRC) Vice Chairman Fang Xinghai explained during the meeting that recent actions were taken to strengthen regulations for companies with consumer-facing platforms, and improve data privacy and national security, the report https://bloom.bg/39iLhKH said, citing people familiar with the matter.

The three-hour meeting of the China-U.S. Financial Roundtable on Thursday included the head of the People’s Bank of China, and executives from Goldman Sachs Group Inc , Citadel and other Wall Street powerhouses, Bloomberg reported.

The CSRC could not be immediately reached for a comment.

Goldman Sachs declined to comment while Citadel did not immediately respond to a request for comment.

Global investors have been spooked in recent months by a flurry of Chinese regulations targeting sectors ranging from technology, gaming and private tutoring.

Fang said the regulator’s actions in the education and gaming sectors were aimed at reducing anxiety in society, according to the report.

(Reporting by Aishwarya Nair in Bengaluru; Editing by Simon Cameron-Moore)

Image Credit: Reuters

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Source: https://datafloq.com/read/china-defends-clampdown-tech-firms-meeting-wall-st-execs-bloomberg-news/17969

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Facebook says WSJ allegations are ‘mischaracterizations,’ confer ‘false motives’

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(Reuters) – Facebook Inc on Saturday slammed a Wall Street Journal series of articles about the social media company’s platform as containing “deliberate mischaracterizations” and said the articles “conferred egregiously false motives to Facebook’s leadership and employees.”

The Wall Street Journal, citing a review of internal company documents that included research reports, online employee discussions and drafts of presentations to senior management, said that although Facebook researchers have identified “the platform’s ill effects,” the company failed to fix them.

The Wall Street Journal articles say that Facebook exempted high-profile users from some or all of its rules, played down the negative effects on young users of its Instagram app, made changes to its algorithm that made the platform “angrier,” and had a weak response to alarms raised by employees over how the platform is used in developing countries by human traffickers.

Nick Clegg, Facebook’s vice president of global affairs, writing in a blog post https://about.fb.com/news/2021/09/what-the-wall-street-journal-got-wrong, said the Wall Street Journal’s stories “contained deliberate mischaracterizations of what we are trying to do, and conferred egregiously false motives to Facebook’s leadership and employees.”

Clegg called “just plain false” an allegation that “Facebook conducts research and then systematically and willfully ignores it if the findings are inconvenient for the company.”

Facebook, Clegg said, understands the “significant responsibility that comes with operating a global platform” and takes it seriously, but “we fundamentally reject this mischaracterization of our work and impugning of the company’s motives.”

Clegg defended Facebook’s handling of posts on the COVID-19 vaccine and said that the “intersection between social media and well-being” remains an evolving issue in the research community.

(Reporting by Juby Babu in Bengaluru; Editing by Leslie Adler)

Image Credit: Reuters

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Source: https://datafloq.com/read/facebook-says-wsj-allegations-mischaracterizations-confer-false-motives/17968

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Big Data

Facebook says WSJ allegations are ‘mischaracterizations,’ confer ‘false motives’

Published

on

(Reuters) – Facebook Inc on Saturday slammed a Wall Street Journal series of articles about the social media company’s platform as containing “deliberate mischaracterizations” and said the articles “conferred egregiously false motives to Facebook’s leadership and employees.”

The Wall Street Journal, citing a review of internal company documents that included research reports, online employee discussions and drafts of presentations to senior management, said that although Facebook researchers have identified “the platform’s ill effects,” the company failed to fix them.

The Wall Street Journal articles say that Facebook exempted high-profile users from some or all of its rules, played down the negative effects on young users of its Instagram app, made changes to its algorithm that made the platform “angrier,” and had a weak response to alarms raised by employees over how the platform is used in developing countries by human traffickers.

Nick Clegg, Facebook’s vice president of global affairs, writing in a blog post https://about.fb.com/news/2021/09/what-the-wall-street-journal-got-wrong, said the Wall Street Journal’s stories “contained deliberate mischaracterizations of what we are trying to do, and conferred egregiously false motives to Facebook’s leadership and employees.”

Clegg called “just plain false” an allegation that “Facebook conducts research and then systematically and willfully ignores it if the findings are inconvenient for the company.”

Facebook, Clegg said, understands the “significant responsibility that comes with operating a global platform” and takes it seriously, but “we fundamentally reject this mischaracterization of our work and impugning of the company’s motives.”

Clegg defended Facebook’s handling of posts on the COVID-19 vaccine and said that the “intersection between social media and well-being” remains an evolving issue in the research community.

(Reporting by Juby Babu in Bengaluru; Editing by Leslie Adler)

Image Credit: Reuters

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Source: https://datafloq.com/read/facebook-says-wsj-allegations-mischaracterizations-confer-false-motives/17968

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