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Oxford Instruments Plasma Technology Releases PTIQ: Intelligent Control Software for Plasma and Ion beam Processing Equipment

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Home > Press > Oxford Instruments Plasma Technology Releases PTIQ: Intelligent Control Software for Plasma and Ion beam Processing Equipment

Abstract:
Oxford Instruments Plasma Technology, a leading provider of plasma and ion beam processing equipment has today launched PTIQ, a new range of control software for their leading-edge plasma processing systems.

Oxford Instruments Plasma Technology Releases PTIQ: Intelligent Control Software for Plasma and Ion beam Processing Equipment


Abingdon, UK | Posted on July 9th, 2020

Frazer Anderson, Innovation and Solutions Director, Plasma Technology, comments: “The PTIQ software has been designed to deliver an exceptional level of responsive system control, reliability and repeatability for our customers. It will optimise their process performance whether that be in the Lab or Fab. We recognise our R&D and high-volume manufacturing (HVM) customers have distinct requirements, and PTIQ caters for that with different levels of software.”

Frazer continues: “PTIQ is SEMI E95 compliant to facilitate rapid, error free process setup and provides automated daily, weekly and monthly checks to optimise uptime which is paramount for our HVM customers. It also assists enhanced yield through fingerprinting and chamber matching and features a flexible batch scheduler allowing throughput optimisation. It is customisable for error free, multiuser operation in any cleanroom environment which we know will be of great benefit to our customers at research facilities. We have also included a recipe editor that matches Oxford Instruments process datasheets for easy, error free transfer of recipes.

The revolutionary software is now available on new system purchases, and as an upgrade for existing customers with PlasmaPro® or Plasmalab® systems.

Dean Furlong, Customer Service Director, Plasma Technology states: “Our systems have a long lifetime, and we want our existing customers to benefit from this new software to optimise operational and process performance with their existing equipment. The upgrade options are available immediately for PlasmaPro and Plasmalab systems, including the ability to transfer recipes.”

####

About Oxford Instruments Plasma Technology
Oxford Instruments Plasma Technology offers flexible, configurable process tools and leading-edge processes for the precise, controllable and repeatable engineering of micro- and nano-structures. Our systems provide process solutions for the etching of nanometre sized features, nanolayer deposition and the controlled growth of nanostructures.

These solutions are based on core technologies in plasma-enhanced deposition and etch, ion-beam deposition and etch, atomic layer deposition, deep silicon etch and physical vapour deposition. Products range from compact stand-alone systems for R&D, through batch tools and up to clustered cassette-to-cassette platforms for high-throughput production processing.

About Oxford Instruments plc

Oxford Instruments designs, supplies and supports high-technology tools and systems with a focus on research and industrial applications. Innovation has been the driving force behind Oxford Instruments’ growth and success for 60 years, supporting its core purpose to address some of the world’s most pressing challenges.

The first technology business to be spun out from Oxford University, Oxford Instruments is now a global company and is listed on the FTSE250 index of the London Stock Exchange (OXIG). Its strategy focuses on being a customer-centric, market-focused Group, understanding the technical and commercial challenges faced by its customers. Key market segments include Semiconductor & Communications, Advanced Materials, Healthcare & Life Science, and Quantum Technology.

Their portfolio includes a range of core technologies in areas such as low temperature and high magnetic field environments; Nuclear Magnetic Resonance; X-ray, electron, laser and optical based metrology; atomic force microscopy; optical imaging; and advanced growth, deposition and etching.

Oxford Instruments is helping enable a greener economy, increased connectivity, improved health and leaps in scientific understanding. Their advanced products and services allow the world’s leading industrial companies and scientific research communities to image, analyse and manipulate materials down to the atomic and molecular level, helping to accelerate R&D, increase manufacturing productivity and make ground-breaking discoveries.

For more information, please click here

Contacts:
Claire Critchell, Marketing Communications Manager

Oxford Instruments Plasma Technology

E: | T: +44 (0)1934 837053

Copyright © Oxford Instruments Plasma Technology

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Source: http://www.nanotech-now.com/news.cgi?story_id=56243

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Arrowhead Interim Clinical Data Demonstrate ARO-AAT Treatment Improved Multiple Biomarkers of Alpha-1 Liver Disease

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Home > Press > Arrowhead Interim Clinical Data Demonstrate ARO-AAT Treatment Improved Multiple Biomarkers of Alpha-1 Liver Disease

Abstract:
– Serum Z-AAT reductions of 86-93%

– All patients demonstrated greater than 80% reduction in liver Z-AAT monomer

– 3 of 4 patients had a decrease in liver globule involvement

– 3 of 4 patients demonstrated reductions in Z-AAT polymer with a range of 68-97%

– All patients showed ALT reductions ranging from 36-66%

Arrowhead Interim Clinical Data Demonstrate ARO-AAT Treatment Improved Multiple Biomarkers of Alpha-1 Liver Disease


Pasadena. CA | Posted on November 13th, 2020

Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) today announced positive interim clinical data from AROAAT2002, an open-label Phase 2 clinical study of ARO-AAT, the company’s second-generation investigational RNA interference (RNAi) therapeutic being developed as a treatment for the rare genetic liver disease associated with alpha-1 antitrypsin deficiency (AATD). The data demonstrate that three doses of ARO-AAT over 24-weeks resulted in consistent reductions of the disease-causing mutant Z protein (Z-AAT) and improvements in clinically relevant biomarkers of liver disease. The results were presented in a late-breaking poster at The Liver Meeting Digital Experience, the Annual Meeting of the American Association for the Study of Liver Disease (AASLD).

A copy of the poster may be accessed on the Events and Presentations page under the Investors section of the Arrowhead website.

Javier San Martin, M.D., chief medical officer at Arrowhead, said: “These data presented at AASLD strongly suggest that ARO-AAT is doing what it’s designed to do, which is reduce the production of the misfolded mutant Z-AAT protein. Moreover, these compelling results indicate that the liver may have the ability to clear out accumulated Z-AAT and begin to heal itself faster than anticipated. Importantly, we saw reductions in serum Z-AAT and liver Z-AAT which led to improvements in multiple markers, such as liver globules, ALT/GGT and Pro-C3. These are all positive indications of a strong pharmacodynamic response and improvement in liver health, following just three doses of ARO-AAT. We anticipate data from additional patient cohorts will be available in the coming months, which will be included in our planned discussions with the U.S. Food and Drug Administration and other regulatory agencies, aimed at exploring areas where the ARO-AAT program could potentially be streamlined and accelerated.”

In the AROAAT2002 study, four patients with homozygous PiZZ alpha-1 antitrypsin deficiency and evidence of fibrosis at screening, each received three doses of ARO-AAT on week 0, 4, and 16. Liver biopsies were performed at screening and at week 24. Assessments included safety (including pulmonary function tests), changes in serum Z-AAT, liver Z-AAT, ALT, GGT, Pro-C3, liver elastography (FibroScan®), and liver globule assessment. Additional histologic adjudication is ongoing.

Key data presented include the following:

Pharmacodynamic Response at 24 weeks

Serum Z-AAT reductions were 86-93%
Total intra-hepatic Z-AAT reductions were 72-95%
All patients demonstrated greater than 80% reduction in liver Z-AAT monomer (soluble)
3 of 4 patients demonstrated reductions in Z-AAT polymer (insoluble) with a range of 68-97%
3 of 4 patients had a decrease in liver globule involvement and 1 subject remained unchanged
All patients showed reductions in ALT (range 36-66%) and in GGT (range 43-58%)
3 of 4 patients demonstrated a substantial reduction of greater than 20% in FibroScan® values
3 of 4 patients showed greater than 30% reduction in serum Pro-C3, a marker of fibrogenesis
Safety

Overall, ARO-AAT 200 mg as a subcutaneous injection was well tolerated in PiZZ AATD subjects
One treatment emergent SAE of Epstein bar virus related myocarditis was reported
No treatment emergent AEs related to change in pulmonary status or pulmonary function were reported
No clinically meaningful changes in ppFEV1 from baseline to Week 24 were observed
In October 2020, Arrowhead and Takeda Pharmaceutical Company Limited announced a collaboration and licensing agreement to develop ARO-AAT. Under the terms of the agreement, Arrowhead and Takeda will co-develop ARO-AAT which, if approved, will be co-commercialized in the U.S. under a 50/50 profit-sharing structure. Outside the U.S., Takeda will lead the global commercialization strategy and receive an exclusive license to commercialize ARO-AAT with Arrowhead eligible to receive tiered royalties of 20-25% on net sales. Arrowhead will receive an upfront payment of $300 million and is eligible to receive potential development, regulatory and commercial milestones up to $740 million. Closing of the transaction is contingent on completion of review under antitrust laws, including the Hart-Scott-Rodino Antitrust Improvements Act of 1976 in the U.S.

AROAAT2002 (NCT03946449) is a pilot open-label, multi-dose, Phase 2 study to assess the response to ARO-AAT in approximately 16 patients with AATD associated liver disease and baseline liver fibrosis who will be enrolled in three cohorts. All eligible participants will require a pre-dose biopsy and an end of study biopsy. Treated participants will also be offered the opportunity to continue treatment in an open-label extension (OLE). Including the OLE, interim assessments will be made after 6 months and 18 months (cohorts 1, 1b), and 12 months and 24 months (cohort 2) of treatment with ARO-AAT. Arrowhead is also evaluating ARO-AAT in the ongoing SEQUOIA Phase 2/3 trial, which began in August 2019.

####

About Arrowhead Pharmaceuticals, Inc.
Arrowhead Pharmaceuticals develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

For more information, please visit www.arrowheadpharma.com, or follow us on Twitter @ArrowheadPharma. To be added to the Company’s email list and receive news directly, please visit http://ir.arrowheadpharma.com/email-alerts .

Safe Harbor Statement under the Private Securities Litigation Reform Act:

This news release contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. These statements are based upon our current expectations and speak only as of the date hereof. Our actual results may differ materially and adversely from those expressed in any forward-looking statements as a result of various factors and uncertainties, including the safety and efficacy of our product candidates, the duration and impact of regulatory delays in our clinical programs, our ability to finance our operations, the likelihood and timing of the receipt of future milestone and licensing fees, the future success of our scientific studies, our ability to successfully develop and commercialize drug candidates, the timing for starting and completing clinical trials, rapid technological change in our markets, and the enforcement of our intellectual property rights. Our most recent Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q discuss some of the important risk factors that may affect our business, results of operations and financial condition. We assume no obligation to update or revise forward-looking statements to reflect new events or circumstances.

For more information, please click here

Contacts:
Arrowhead Pharmaceuticals, Inc.
Vince Anzalone, CFA
626-304-3400

Investors:
LifeSci Advisors, LLC
Brian Ritchie
212-915-2578
www.lifesciadvisors.com

Media:
LifeSci Communications, LLC
Josephine Belluardo, Ph.D.
646-751-4361
www.lifescicommunications.com

Copyright © Arrowhead Pharmaceuticals, Inc.

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

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Arrowhead Presents New Clinical Data on Cardiometabolic Pipeline at AHA 2020

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Home > Press > Arrowhead Presents New Clinical Data on Cardiometabolic Pipeline at AHA 2020

Abstract:
– ARO-APOC3 achieved triglyceride reductions of 74-92%

– ARO-ANG3 achieved triglyceride reductions of 29-75% and LCL-C reductions of 29-35%

– Company to host upcoming KOL webinars on ARO-APOC3 and ARO-ANG3

Arrowhead Presents New Clinical Data on Cardiometabolic Pipeline at AHA 2020


Pasadena. CA | Posted on November 13th, 2020

Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) today announced positive clinical data from multiple product candidates in its cardiometabolic pipeline at the American Heart Association (AHA) Scientific Sessions 2020.

Javier San Martin, M.D., chief medical officer at Arrowhead, said: “The data presented at AHA on our cardiometabolic pipeline continue to show strong and consistent response across a range of lipid parameters. There remains significant residual cardiovascular risk despite recent scientific advances, and we believe that our cardiometabolic pipeline has the ability to target new therapeutic targets and address multiple lipid parameters associated with increased cardiovascular risk.”

Copies of the following presentations may be accessed on the Events and Presentations page under the Investors section of the Arrowhead website:

Title: Pharmacodynamic effect of ARO-ANG3, an investigational RNA interference therapeutic targeting hepatic angiopoietin-like protein 3, in patients with hypercholesterolemia
Authors: Gerald F. Watts, et al.
Session: Advances in Understanding and Treatment of Dyslipidemia and New Therapies for CVD

Title: Pharmacodynamic effect of ARO-APOC3, an investigational hepatocyte-targeted RNA interference therapeutic targeting apolipoprotein C3, in patients with hypertriglyceridemia and multifactorial chylomicronemia
Authors: Christie Ballantyne, presenting on behalf of Peter Clifton, et al.
Session: Advances in Understanding and Treatment of Dyslipidemia and New Therapies for CVD

Title: Safety, Tolerability and Efficacy of Single-Dose AMG 890, a Novel siRNA Targeting Lp(a), in Healthy Subjects and Subjects with Elevated Lp(a)
Authors: Michael J. Koren, et al.
Session: Advances in Understanding and Treatment of Dyslipidemia and New Therapies for CVD

Arrowhead will also host two key opinion leader (KOL) webinars on November 18, and November 19, 2020 to discuss data from, and the company’s future plans for, its two investigational cardiometabolic candidates, ARO-APOC3 and ARO-ANG3. The webinars may be accessed on the Events and Presentations page under the Investors section of the Arrowhead website.

####

About Arrowhead Pharmaceuticals, Inc.
Arrowhead Pharmaceuticals develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

For more information, please visit www.arrowheadpharma.com, or follow us on Twitter @ArrowheadPharma. To be added to the Company’s email list and receive news directly, please visit http://ir.arrowheadpharma.com/email-alerts .

Safe Harbor Statement under the Private Securities Litigation Reform Act:

This news release contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. These statements are based upon our current expectations and speak only as of the date hereof. Our actual results may differ materially and adversely from those expressed in any forward-looking statements as a result of various factors and uncertainties, including the safety and efficacy of our product candidates, the duration and impact of regulatory delays in our clinical programs, our ability to finance our operations, the likelihood and timing of the receipt of future milestone and licensing fees, the future success of our scientific studies, our ability to successfully develop and commercialize drug candidates, the timing for starting and completing clinical trials, rapid technological change in our markets, and the enforcement of our intellectual property rights. Our most recent Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q discuss some of the important risk factors that may affect our business, results of operations and financial condition. We assume no obligation to update or revise forward-looking statements to reflect new events or circumstances.

For more information, please click here

Contacts:
Arrowhead Pharmaceuticals, Inc.
Vince Anzalone, CFA
626-304-3400

Investors:
LifeSci Advisors, LLC
Brian Ritchie
212-915-2578
www.lifesciadvisors.com

Media:
LifeSci Communications, LLC
Josephine Belluardo, Ph.D.
646-751-4361
www.lifescicommunications.com

Copyright © Arrowhead Pharmaceuticals, Inc.

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

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CCNY & partners in quantum algorithm breakthrough

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Home > Press > CCNY & partners in quantum algorithm breakthrough

The Google Quantum Computer. Photo courtesy of Google Quantum AI
The Google Quantum Computer. Photo courtesy of Google Quantum AI

Abstract:
Researchers led by City College of New York physicist Pouyan Ghaemi report the development of a quantum algorithm with the potential to study a class of many-electron quantums system using quantum computers. Their paper, entitled “Creating and Manipulating a Laughlin-Type ν=1/3 Fractional Quantum Hall State on a Quantum Computer with Linear Depth Circuits,” appears in the December issue of PRX Quantum, a journal of the American Physical Society.

CCNY & partners in quantum algorithm breakthrough


New York, NY | Posted on November 13th, 2020

“Quantum physics is the fundamental theory of nature which leads to formation of molecules and the resulting matter around us,” said Ghaemi, assistant professor in CCNY’s Division of Science. “It is already known that when we have a macroscopic number of quantum particles, such as electrons in the metal, which interact with each other, novel phenomena such as superconductivity emerge.”

However, until now, according to Ghaemi, tools to study systems with large numbers of interacting quantum particles and their novel properties have been extremely limited.

“Our research has developed a quantum algorithm which can be used to study a class of many-electron quantum systems using quantum computers. Our algorithm opens a new venue to use the new quantum devices to study problems which are quite challenging to study using classical computers. Our results are new and motivate many follow up studies,” added Ghaemi.

On possible applications for this advancement, Ghaemi, who’s also affiliated with the Graduate Center, CUNY noted: “Quantum computers have witnessed extensive developments during the last few years. Development of new quantum algorithms, regardless of their direct application, will contribute to realize applications of quantum computers.

“I believe the direct application of our results is to provide tools to improve quantum computing devices. Their direct real-life application would emerge when quantum computers can be used for daily life applications.”

###

His collaborators included scientists from: Western Washington University, University of California, Santa Barbara; Google AI Quantum and the University of Michigan, Ann Arbor.

####

For more information, please click here

Contacts:
Jay Mwamba
917-892-0374

Copyright © City College of New York

If you have a comment, please Contact us.

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Source: http://www.nanotech-now.com/news.cgi?story_id=56431

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Anions matter: Zinc-ion hybrid capacitors with ideal anions in the electrolyte show extra-long performance

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Home > Press > Anions matter: Zinc-ion hybrid capacitors with ideal anions in the electrolyte show extra-long performance

© Wiley-VCH, re-use with credit to 'Angewandte Chemie' and a link to the original article.
© Wiley-VCH, re-use with credit to ‘Angewandte Chemie’ and a link to the original article.

Abstract:
Metal-ion hybrid capacitors combine the properties of capacitors and batteries. One electrode uses the capacitive mechanism, the other the battery-type redox processes. Scientists have now scrutinized the role of anions in the electrolyte. The results, which have been published in the journal Angewandte Chemie, reveal the importance of sulfate anions. Sulfate-based electrolytes gave zinc-ion hybrid capacitors outstanding performance and extra-long operability.

Anions matter: Zinc-ion hybrid capacitors with ideal anions in the electrolyte show extra-long performance


Heidelberg, Germany | Posted on November 13th, 2020

Capacitors can uptake and release an enormous amount of charge in a short time, whereas batteries can store a lot of energy in a small volume. To combine both properties, scientists are investigating hybrid electrochemical cells, which contain both capacitor- and battery-type electrodes. Among these cells, researchers have identified metal-ion hybrid capacitors as especially promising devices. Here, the positive electrode includes pseudocapacitive properties, which means it can also store energy in the manner of a battery, by intercalation of the metal ions, while the negative electrode is made of a redox-active metal.

However, their electrolyte has long been neglected, says Chunyi Zhi who is investigating battery materials together with his team at the City University of Hong Kong. The researchers believe the type of electrolyte anion affects the performance of the device. “Paying more attention to the introduction of appropriate anions can effectively improve the power and energy density of a capacitor,” they say.

The researchers focused their attention on zinc-ion capacitors. This cell type consists of a zinc metal anode and a cathode made of titanium nitride nanofibers. The nanofibers are robust, and their porous surface allows the electrolyte to infiltrate. The scientists argue that the electrolyte anions, when attached to the titanium nitride surface, make the material more conductive. Moreover, the adsorbed anions may directly contribute to the charging process. The charging of the hybrid capacitor involves the extraction of the intercalated zinc ions.

Zhi and his colleagues compared the effects of three electrolyte anions: sulfate, acetate, and chloride. They looked at both their binding to the electrode surface and the performances of the electrochemical cells. It was a clear result.

The scientists reported that the sulfate anions stood out among the three anions. They observed that cells based on a zinc sulfate electrolyte performed best, and the sulfates bound stronger to the titanium nitride surface than the other anions. Moreover, sulfate-treated electrodes showed the lowest self-discharging. The authors attributed the findings to the electronic effects of sulfate. Its electron-pulling nature provides tight binding to the surface atoms and prevents the electrode from self-discharging, the authors concluded.

For a zinc-sulfate-based zinc-ion hybrid capacitor, the scientists reported high-performance operation for more than nine months. Moreover, these devices are flexible, which is especially useful for portable electronics. The scientists tested the device in an electronic watch and found excellent performance.

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About the Author

Dr. Chunyi Zhi is a Professor at the Department of Materials Science & Engineering at the City University of Hong Kong. His research interests span the practical application of flexible energy-storage devices, zinc-based batteries with new electrode materials and electrolytes, and catalysts for oxygen and nitrogen reduction reactions.

http://www.comfortablenergy.net/

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