Connect with us

Biotechnology

New bionics center established at MIT with $24 million gift

Published

on

A deepening understanding of the brain has created unprecedented opportunities to alleviate the challenges posed by disability. Scientists and engineers are taking design cues from biology itself to create revolutionary technologies that restore the function of bodies affected by injury, aging, or disease — from prosthetic limbs that effortlessly navigate tricky terrain to digital nervous systems that move the body after a spinal cord injury.

With the establishment of the new K. Lisa Yang Center for Bionics, MIT is pushing forward the development and deployment of enabling technologies that communicate directly with the nervous system to mitigate a broad range of disabilities. The center’s scientists, clinicians, and engineers will work together to create, test, and disseminate bionic technologies that integrate with both the body and mind.

The center is funded by a $24 million gift to MIT’s McGovern Institute for Brain Research from philanthropist Lisa Yang, a former investment banker committed to advocacy for individuals with visible and invisible disabilities. Her previous gifts to MIT have also enabled the establishment of the K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience, Hock E. Tan and K. Lisa Yang Center for Autism Research, Y. Eva Tan Professorship in Neurotechnology, and the endowed K. Lisa Yang Post-Baccalaureate Program.

“The K. Lisa Yang Center for Bionics will provide a dynamic hub for scientists, engineers, and designers across MIT to work together on revolutionary answers to the challenges of disability,” says MIT President L. Rafael Reif. “With this visionary gift, Lisa Yang is unleashing a powerful collaborative strategy that will have broad impact across a large spectrum of human conditions — and she is sending a bright signal to the world that the lives of individuals who experience disability matter deeply.”

Video thumbnail Play video

“K. Lisa Yang Center for Bionics”
Video by Jimmy Day/MIT Media Lab

An interdisciplinary approach

To develop prosthetic limbs that move as the brain commands or optical devices that bypass an injured spinal cord to stimulate muscles, bionic developers must integrate knowledge from a diverse array of fields — from robotics and artificial intelligence to surgery, biomechanics, and design. The K. Lisa Yang Center for Bionics will be deeply interdisciplinary, uniting experts from three MIT schools: Science, Engineering, and Architecture and Planning. With clinical and surgical collaborators at Harvard Medical School, the center will ensure that research advances are tested rapidly and reach people in need, including those in traditionally underserved communities.

To support ongoing efforts to move toward a future without disability, the center will also provide four endowed fellowships for MIT graduate students working in bionics or other research areas focused on improving the lives of individuals who experience disability.

“I am thrilled to support MIT on this major research effort to enable powerful new solutions that improve the quality of life for individuals who experience disability,” says Yang. “This new commitment extends my philanthropic investment into the realm of physical disabilities, and I look forward to the center’s positive impact on countless lives, here in the U.S. and abroad.”

The center will be led by Hugh Herr, a professor of media arts and sciences at MIT’s Media Lab, and Ed Boyden, the Y. Eva Tan Professor of Neurotechnology at MIT, a professor of biological engineering, brain and cognitive sciences, and media arts and sciences, and an investigator at MIT’s McGovern Institute and the Howard Hughes Medical Institute.

A double amputee himself, Herr is a pioneer in the development of bionic limbs to improve mobility for those with physical disabilities.“The world profoundly needs relief from the disabilities imposed by today’s nonexistent or broken technologies. We must continually strive towards a technological future in which disability is no longer a common life experience,” says Herr. “I am thrilled that the Yang Center for Bionics will help to measurably improve the human experience for so many.”

Boyden, who is a renowned creator of tools to analyze and control the brain, will play a key role in merging bionics technologies with the nervous system. “The Yang Center for Bionics will be a research center unlike any other in the world,” he says. “A deep understanding of complex biological systems, coupled with rapid advances in human-machine bionic interfaces, mean we will soon have the capability to offer entirely new strategies for individuals who experience disability. It is an honor to be part of the center’s founding team.”

Center priorities

In its first four years, the K. Lisa Yang Center for Bionics will focus on developing and testing three bionic technologies: 

  • digital nervous system, to eliminate movement disorders caused by spinal cord injuries using computer-controlled muscle activations to regulate limb movements while simultaneously stimulating spinal cord repair;
  • brain-controlled limb exoskeletons, to assist weak muscles and enable natural movement for people affected by stroke or musculoskeletal disorders; and
  • bionic limb reconstruction, to restore natural, brain-controlled movements as well as the sensation of touch and proprioception (awareness of position and movement) from bionic limbs.

A fourth priority will be developing a mobile delivery system to ensure patients in medically underserved communities have access to prosthetic limb services. Investigators will field-test a system that uses a mobile clinic to conduct the medical imaging needed to design personalized, comfortable prosthetic limbs and to fit the prostheses to patients where they live. Investigators plan to initially bring this mobile delivery system to Sierra Leone, where thousands of people suffered amputations during the country’s 11-year civil war. While the population of persons with amputation continues to increase each year in Sierra Leone, today less than 10 percent of persons in need benefit from functional prostheses. Through the mobile delivery system, a key center objective is to scale up production and access of functional limb prostheses for Sierra Leoneans in dire need.

“The mobile prosthetics service fueled by the K. Lisa Yang Center for Bionics at MIT is an innovative solution to a global problem,” says Julius Maada Bio, president of Sierra Leone. “I am proud that Sierra Leone will be the first site for deploying this state-of-the-art digital design and fabrication process. As leader of a government that promotes innovative technologies and prioritizes human capital development, I am overjoyed that this pilot project will give Sierra Leoneans (especially in rural areas) access to quality limb prostheses and thus improve their quality of life.”

Together, Herr and Boyden will launch research at the bionics center with three other MIT faculty: assistant professor of media arts and sciences Canan Dagdeviren, Walter A. Rosenblith Professor of Cognitive Neuroscience Nancy Kanwisher, and David H. Koch (1962) Institute Professor Robert Langer. They will work closely with three clinical collaborators at Harvard Medical School: Marco Ferrone, an orthopedic surgeon; Matthew Carty, a plastic surgeon; and Nancy Oriol, Faculty Associate Dean for Community Engagement in Medical Education.

“Lisa Yang and I share a vision for a future in which each and every person in the world has the right to live without a debilitating disability if they so choose,” adds Herr. “The Yang Center will be a potent catalyst for true innovation and impact in the bionics space, and I am overjoyed to work with my colleagues at MIT, and our accomplished clinical partners at Harvard, to make important steps forward to help realize this vision.”

PlatoAi. Web3 Reimagined. Data Intelligence Amplified.
Click here to access.

Source: https://news.mit.edu/2021/new-bionics-center-established-mit-24-million-gift-0923

Biotechnology

Documentary short, “The Uprising,” showcases women in science who pressed for equal rights at MIT in the 1990s

Published

on

The MIT Press today announced the digital release of “The Uprising,” a documentary short about the unprecedented behind-the-scenes effort that amassed irrefutable evidence of differential treatment of men and women on the MIT faculty in the 1990s. Directed by Ian Cheney and Sharon Shattuck, the film premiered on the MIT Press’ YouTube channel, and is now openly distributed. 

A 13-minute film, “The Uprising” introduces the story behind the 1999 Study on the Status of Women Faculty in Science at MIT and its impact both at the Institute and around the globe. Featuring Nancy Hopkins, professor emerita of biology at MIT, the film chronicles the experiences of marginalization and discouragement that accompanied Hopkins’ research leading up to the study and further highlights the steps a group of 16 female faculty members took to make science more diverse and equitable.

The MIT report is today widely credited with advancing gender equity in universities both nationally and internationally. This ripple effect is highlighted in the film by Hopkins, who says, “Look at the talent of these women. This is what you lose when you do not solve this problem. It’s true not just of women, it’s true of minorities, it’s true of all groups that get excluded. It’s all of that talent that you lose. For me, the success of these women is the reward for the work we did. That’s really what it’s about. It’s about the science.”

“The Uprising” features interviews with leading current and former MIT scientists, including social psychologist Lotte Bailyn, biomedical engineer Sangeeta N. Bhatia, chemist Sylvia Ceyer, ecologist Sallie “Penny” Chisholm, materials engineer Lorna Gibson, biologist Ruth Lehmann, geophysicist and National Academy of Sciences President Marcia McNutt, cognitive scientist Mary Potter, oceanographer Paola Rizzoli, geophysicist Leigh Royden, and biologist Lisa Steiner. “The Uprising” was produced in conjunction with the feature-length documentary film, “Picture a Scientist.

“The Uprising” was funded by a grant from the Alfred P. Sloan Foundation, as well as support from Nancy Blachman and an anonymous donor. The film was produced by Manette Pottle, in collaboration with the MIT Press. Amy Brand, director and publisher at the MIT Press, served as executive producer. 

PlatoAi. Web3 Reimagined. Data Intelligence Amplified.
Click here to access.

Source: https://news.mit.edu/2021/documentary-short-the-uprising-women-science-equal-rights-mit-1014

Continue Reading

Biotechnology

Volta Labs: Improving workflows for genetic applications

Published

on

The cost of DNA sequencing has plummeted at a rate faster than Moore’s Law, opening large markets in the sequencing space. Genomics for cancer care alone is predicted to hit $23 billion by 2025, but sample preparation costs for sequencing have stagnated, causing a significant bottleneck in the space.

Conventional sample preparation, converting DNA from a saliva sample, for example, into something that can be fed to a sequencing machine, relies on a liquid-handling robot. It is essentially a mechanical arm equipped with pipette tips that moves liquid samples to plastic plates and other instruments placed on the deck. These systems involve multiple fluidic transfers that lead to poor utilization of reagents and samples, which means less DNA sequenced. Moreover, they are systems of separate data silos that lack integration and rely on expensive consumables.

Unlike traditional liquid-handling automation, the suite of solutions developed by MIT Media Lab spinoff Volta Labs provides end-to-end integration for a wide variety of workflows. It’s a sleek alternative to costly liquid handling machines and manual pipetting. “Our technology is a small-scale, benchtop device that is low-cost and has minimal consumable usage, enabling rapid and flexible composition of new biological workflows,” says Volta Labs co-founder and Head of Engineering Will Langford SM ’14, PhD ’19.

The Volta platform is based on digital microfluidic technology developed at MIT by Langford’s co-founder, Volta Labs CEO Udayan Umapathi SM ’17. The core principle behind the innovation is called electrowetting. It allows its users to manipulate droplets around a printed circuit board to perform biological reactions, automating from raw sample to prepared library that can be run on a sequencing machine.

Umapathi arrived at the Media Lab with what he describes as “a fascination for building automation from the ground up.” Though trained as an engineer, Umapathi has applied his skills to a variety of fields. In 2015, he founded a startup that created web and physical tools to enable content creation for digital manufacturing. However, it was while working for a synthetic biology company, engineering liquid-handling systems for genome engineering solutions, that he identified the scaling up of automation as a pain point for the field.

Meanwhile, Langford spent his MIT days at the Center for Bits and Atoms, a proudly interdisciplinary program that explores the boundary between computer science and physical science. His research centered on the idea that engineering could learn from biology. Put another way, all of life is assembled from 20 amino acids, so, thought Langford, why not attempt something similar with engineering?

In practice, this meant he built integrated robots from a small set of millimeter-scale parts. “Ultimately, I was trying to make engineering more like biology,” he reflects. “I see Volta as an opportunity to flip that on its head and use automation to treat biology more like engineering. We want to give biologists tools to manipulate liquids and biological reactions at a finer granularity and with more digital flexibility.”

While Volta’s automation platform simplifies sample prep by integrating complicated workflows, it also drives down costs in the space with a new consumable construction. Between the circuit board and the sample board is a consumable layer, which is removed and replaced after each run. Conventional consumables are expensive, conductively coded plastics or large microfluidic structures. Volta, however, uses a simple plastic film to reduce the cost of consumables, which opens the door for the widespread adoption of gene sequencing.

All of this points to a more efficient and inclusionary model in the gene sequencing space. Thanks to Volta, soon, it won’t be just large biotechnology companies with the ability to invest in automation. Academic labs, core facilities, and small-to-medium biotech companies won’t need to worry about whether they can afford an expensive mechanical robot. “The thing that excites me is that we’re providing early-stage and mid-to-low-throughput biotech companies with powerful tools that will allow them to compete with bigger players, which is good for the industry as a whole,” says Umapathi.

And the fact is that traditional automation machines used in the biotechnology space come with their own set of problems. They’re error-prone and you can’t scale them. Consider Illumina’s NovaSeq sequencer. It’s capable of sequencing 48 whole human genomes in under two days — that’s 20 billion unique reads — but there is currently no automation to feed those machines at scale. “To run those machines day in and day out, the cost simply doesn’t make sense, which is why we have to tackle the cost of sequencing and sample prep,” says Umapathi.

Volta’s system is built on solid-state electronics, and the Boston-based startup is looking to leverage the scalability of the semiconductor fabrication industry and the PCB manufacturing industry. “The goal,” explains Langford, “is to enable biologists to create an experiment and modify it quickly, iterate on it, and generate the data necessary to see biology at scale.”

Beyond the sample prep bottleneck, eventually, the work of Umapathi and Langfordwork will impact a variety of applications in the synthetic biology industry and the biopharma industry. Diagnostics will be transformed, according to Umapathi. “We can help the biology industry by cutting down on the use of pipette tips by 20 or 50 times. In specific workflows, we can almost entirely eliminate this bottleneck in the supply chain,” he says.

To accomplish all of this, to truly innovate in a field as complex as biology, Umapathi and Langford insist that a multidisciplinary systems perspective is essential. It’s what informs the Volta approach to genomic sequencing in particular, and biology as a whole. “Volta is a new type of biotechnology company,” says Umapathi. “It’s inevitable that more engineers and systems thinkers and those who want to build tools to engineer biology better will join companies like ours or start their own.”

Turning biology into an engineering principle is no small feat, but according to Umapathi and Langford, it’s a necessity.

PlatoAi. Web3 Reimagined. Data Intelligence Amplified.
Click here to access.

Source: https://news.mit.edu/2021/volta-labs-improving-workflows-genetic-applications-1014

Continue Reading

Biotechnology

Cellular environments shape molecular architecture

Published

on

Context matters. It’s true for many facets of life, including the tiny molecular machines that perform vital functions inside our cells.

Scientists often purify cellular components, such as proteins or organelles, in order to examine them individually. However, a new study published today in the journal Nature suggests that this practice can drastically alter the components in question.

The researchers devised a method to study a large, donut-shaped structure called the nuclear pore complex (NPC) directly inside cells. Their results revealed that the pore had larger dimensions than previously thought, emphasizing the importance of analyzing complex molecules in their native environments.

“We’ve shown that the cellular environment has a significant impact on large structures like the NPC, which was something we weren’t expecting when we started,” says Thomas Schwartz, the Boris Magasanik Professor of Biology at MIT and the study’s co-senior author. “Scientists have generally thought that large molecules are stable enough to maintain their fundamental properties both inside and outside a cell, but our findings turn that assumption on its head.”

In eukaryotes like humans and animals, most of a cell’s DNA is stored in a rounded structure called the nucleus. This organelle is shielded by the nuclear envelope, a protective barrier that separates the genetic material in the nucleus from the thick fluid filling the rest of the cell. But molecules still need a way to come in and out of the nucleus in order to facilitate important processes, including gene expression. That’s where the NPC comes in. Hundreds — sometimes thousands — of these pores are embedded in the nuclear envelope, creating gateways that allow certain molecules to pass.

The study’s first author, former MIT postdoc Anthony Schuller, compares NPCs to gates at a sports stadium. “If you want to access the game inside, you have to show your ticket and go through one of these gates,” he explains.

Video thumbnail Play video

A Closer Look at the Nuclear Pore Complex

CR = Cytoplasmic Ring
IR = Inner Ring
NR = Nucleoplasmic Ring

The NPC may be tiny by human standards, but it’s one of the largest structures in the cell. It’s comprised of roughly 500 proteins, which has made its structure challenging to parse. Traditionally, scientists have broken it up into individual components to study it piecemeal using a method called X-ray crystallography. According to Schwartz, the technology required to analyze the NPC in a more natural environment has only recently become available.

Together with researchers from the University of Zurich, Schuller and Schwartz employed two cutting-edge approaches to solve the pore’s structure: cryo-focused ion beam (cryo-FIB) milling and cryo-electron tomography (cryo-ET).

An entire cell is too thick to look at under an electron microscope. But the researchers sliced frozen colon cells into thin layers using the cryo-FIB equipment housed at MIT.nano’s Center for Automated Cryogenic Electron Microscopy and the Koch Institute for Integrative Cancer Research’s Peterson (1957) Nanotechnology Materials Core Facility. In doing so, the team captured cross-sections of the cells that included NPCs, rather than simply looking at the NPCs in isolation.

“The amazing thing about this approach is that we’ve barely manipulated the cell at all,” Schwartz says. “We haven’t perturbed the cell’s internal structure. That’s the revolution.”

What the researchers saw when they looked at their microscopy images was quite different from existing descriptions of the NPC. They were surprised to find that the innermost ring structure, which forms the pore’s central channel, is much wider than previously thought. When it’s left in its natural environment, the pore opens up to 57 nanometers — resulting in a 75 percent increase in volume compared to previous estimates. The team was also able to take a closer look at how the NPC’s various components work together to define the pore’s dimensions and overall architecture.

“We’ve shown that the cellular environment impacts NPC structure, but now we have to figure out how and why,” Schuller says. Not all proteins can be purified, he adds, so the combination of cryo-ET and cryo-FIB will also be useful for examining a variety of other cellular components. “This dual approach unlocks everything.”

“The paper nicely illustrates how technical advances, in this case cryo-electron tomography on cryo-focused ion beam milled human cells, provide a fresh picture of cellular structures,” says Wolfram Antonin, a professor of biochemistry at RWTH Aachen University in Germany who was not involved in the study. The fact that the diameter of the NPC’s central transport channel is larger than previously thought hints that the pore could have impressive structural flexibility. “That may be important for the cell to adapt to increased transport demands,” Antonin explains.

Next, Schuller and Schwartz hope to understand how the size of the pore affects which molecules can pass through. For instance, scientists only recently determined that the pore was big enough to allow intact viruses like HIV into the nucleus. The same principle applies to medical treatments: only appropriately-sized drugs with specific properties will be able to access the cell’s DNA.

Schwartz is especially curious to know whether all NPCs are created equal, or if their structure differs between species or cell types.

“We’ve always manipulated cells and taken the individual components out of their native context,” he says. “Now we know this method may have much bigger consequences than we thought.”

PlatoAi. Web3 Reimagined. Data Intelligence Amplified.
Click here to access.

Source: https://news.mit.edu/2021/cellular-environments-shape-molecular-architecture-1013

Continue Reading

Biotechnology

Seven from MIT receive National Institutes of Health awards for 2021

Published

on

On Oct. 5, the National Institutes of Health announced the names of 106 scientists who have been awarded grants through the High-Risk, High-Reward Research program to advance highly innovative biomedical and behavioral research. Seven of the recipients are MIT faculty members.

The High-Risk, High-Reward Research program catalyzes scientific discovery by supporting research proposals that, due to their inherent risk, may struggle in the traditional peer-review process despite their transformative potential. Program applicants are encouraged to pursue trailblazing ideas in any area of research relevant to the NIH’s mission to advance knowledge and enhance health.

“The science put forward by this cohort is exceptionally novel and creative and is sure to push at the boundaries of what is known,” says NIH Director Francis S. Collins. “These visionary investigators come from a wide breadth of career stages and show that groundbreaking science can happen at any career level given the right opportunity.”

New innovators

Four MIT researchers received New Innovator Awards, which recognize “unusually innovative research from early career investigators.” They are:

  • Pulin Li is a member at the Whitehead Institute for Biomedical Research and an assistant professor in the Department of Biology. Li combines approaches from synthetic biology, developmental biology, biophysics and systems biology to quantitatively understand the genetic circuits underlying cell-cell communication that creates multicellular behaviors.
     
  • Seychelle Vos, the Robert A. Swanson (1969) Career Development Professor of Life Sciences in the Department of Biology, studies the interplay of gene expression and genome organization. Her work focuses on understanding how large molecular machineries involved in genome organization and gene transcription regulate each others’ function to ultimately determine cell fate and identity.
     
  • Xiao Wang, the Thomas D. and Virginia Cabot Assistant Professor of Chemistry and a member of the Broad Institute of MIT and Harvard, aims to develop high-resolution and highly-multiplexed molecular imaging methods across multiple scales toward understanding the physical and chemical basis of brain wiring and function.
     
  • Alison Wendlandt is a Cecil and Ida Green Career Development Assistant Professor of Chemistry. Wendlandt focuses on the development of selective, catalytic reactions using the tools of organic and organometallic synthesis and physical organic chemistry. Mechanistic study plays a central role in the development of these new transformations.

Transformative researchers

Two MIT researchers have received Transformative Research Awards, which “promote cross-cutting, interdisciplinary approaches that could potentially create or challenge existing paradigms.” The recipients are:

  • Manolis Kellis is a professor of computer science at MIT in the area of computational biology, an associate member of the Broad Institute, and a principal investigator with MIT’s Computer Science and Artificial Intelligence Laboratory. He aims to further our understanding of the human genome by computational integration of large-scale functional and comparative genomics datasets.
  • Myriam Heiman is the Latham Family Career Development Associate Professor of Neuroscience in the Department of Brain and Cognitive Sciences and an investigator in the Picower Institute for Learning and Memory. Heiman studies the selective vulnerability and pathophysiology seen in two neurodegenerative diseases of the basal ganglia, Huntington’s disease, and Parkinson’s disease.

Together, Heiman, Kellis and colleagues will launch a five-year investigation to pinpoint what may be going wrong in specific brain cells and to help identify new treatment approaches for amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with motor neuron disease (FTLD/MND). The project will bring together four labs, including Heiman and Kellis’ labs at MIT, to apply innovative techniques ranging from computational, genomic, and epigenomic analyses of cells from a rich sample of central nervous system tissue, to precision genetic engineering of stem cells and animal models.

Pioneering researchers

  • Polina Anikeeva received a Pioneer Award, which “challenges investigators at all career levels to pursue new research directions and develop groundbreaking, high-impact approaches to a broad area of biomedical, behavioral, or social science.” Anikeeva is an MIT professor of materials science and engineering, a professor of brain and cognitive sciences, and a McGovern Institute for Brain Research associate investigator. She has established a research program that uniquely combines materials synthesis, device fabrication, neurophysiology, and animal models of behavior. Her group carries out projects that understand, invent, and design materials from the level of atoms to functional devices with applications in fundamental neuroscience.

The program is supported by the NIH Common Fund, which oversees programs that pursue major opportunities and gaps throughout the research enterprise that are of great importance to NIH and require collaboration across the agency to succeed. It issues four awards each year: the Pioneer Award, the New Innovator Award, the Transformative Research Award, and the Early Independence Award.

This year, NIH issued 10 Pioneer awards, 64 New Innovator awards, 19 Transformative Research awards (10 general, four ALS-related, and five Covid-19-related), and 13 Early Independence awards for 2021. Funding for the awards comes from the NIH Common Fund, the National Institute of General Medical Sciences, the National Institute of Mental Health, and the National Institute of Neurological Disorders and Stroke.

PlatoAi. Web3 Reimagined. Data Intelligence Amplified.
Click here to access.

Source: https://news.mit.edu/2021/mit-faculty-national-institutes-health-awards-1006

Continue Reading
Low_Car33ElfynEvansScott-Martin.jpg
Automotive5 days ago

Evans and TOYOTA GAZOO Racing Seal Second in Spain

Automotive4 days ago

This Toyota Mirai 1:10 Scale RC Car Actually Runs On Hydrogen

Fintech4 days ago

PNC cuts nearly 600 apps for BBVA conversion

Automotive1 day ago

7 Secrets That Automakers Wish You Don’t Know

Blockchain11 hours ago

People’s payment attitude: Why cash Remains the most Common Means of Payment & How Technology and Crypto have more Advantages as a Means of payment

Blockchain1 day ago

What Is the Best Crypto IRA for Me? Use These 6 Pieces of Criteria to Find Out More

Cyber Security4 days ago

Spotify Web Player

Aviation5 days ago

Vaccine passports for overseas travel to be rolled out this week

Gaming1 day ago

New Steam Games You Might Have Missed In August 2021

IOT1 day ago

The Benefits of Using IoT SIM Card Technology

Blockchain1 day ago

The Most Profitable Cryptocurrencies on the Market

Esports4 days ago

New World team share details of upcoming server transfers in Q&A

Gaming1 day ago

How do casinos without an account work?

Esports5 days ago

New World Animal Instincts Quest Details

Startups11 hours ago

The 12 TikTok facts you should know

Esports4 days ago

How TFT Set 6 Hextech Augments work: full list and updates

Energy4 days ago

Segunda Conferência Ministerial de Energia da Rota e Cinturão é realizada em Qingdao

Blockchain2 days ago

What does swapping crypto mean?

Gaming1 day ago

Norway will crack down on the unlicensed iGaming market with a new gaming law

Payments5 days ago

Everyone is building a wallet

Trending