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Kintor’s Proxalutamide (GT0918) COVID-19 Clinical Trial Shows Positive Preliminary Results in Treatment of Female Patients

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This trial commenced the enrolment of 168 female patients on Nov, 2020 after receiving the encouraging results from male patients. Eligible female patients were randomized in a 2:1 ratio to receive either Proxalutamide + standard care (Proxalutamide arm) or Placebo + standard care (Control arm). The co-primary endpoints of the clinical trial are the percentage of subjects hospitalized with COVID-19 and the COVID-19 Ordinal Outcome Scale (a 8-point ordinal scale used by the US National Institute of Allergy and Infection Diseases, such as mechanical ventilation usage and death) in 30 days.

The interim analysis conducted on Jan 7, 2021 was based on 60 patients in Proxalutamide arm and 35 patients in the control arm. The percentage of hospitalization, admission to ICU, mechanical ventilation requirement and death was 1.7% vs. 17.1%, 0% vs. 8.6%, 0% vs. 5.7% and 0%, vs. 2.9% in Proxalutamide and placebo arms respectively.

The trial is expected to conclude enrolment in February 2021, and finalize the data collection by March 2021.

Dr. Tong Youzhi, the founder, Chairman and CEO of Kintor Pharmaceutical, said, “first of all, we would like to give special thanks to all the healthcare workers fighting the worldwide COVID-19 pandemic. Special thanks to the AndroCoV[1][2] group led by Dr. Andy Goren, Dr. Flávio Adsuara Cadegiani, Dr. John McCoy and Dr. Carlos Gustavo Wambier, who are conducting this important investigator initiated study. Although the female group has lower androgen level as compared to male group, the data showed that Proxalutamide could significantly ameliorate symptoms and prevent hospitalization for COVID-19 female patients, which paves the way for our phase III MRCT registrational trial in the near future.”

Related Links
[1]Ministry of Health prepares actions to strengthen the SUS in Manaus
https://www.gov.br/saude/pt-br/assuntos/noticias/ministerio-da-saude-prepara-acoes-para-reforco-do-sus-em-manaus
[2]COVID-19 AndroCoV Protocol Pioneered by Applied Biology and Brazilian Scientists Adopted by the Brazilian Government
https://www.einnews.com/pr_news/534176202/covid-19-androcov-protocol-pioneered-by-applied-biology-and-brazilian-scientists-adopted-by-the-brazilian-government

SOURCE Kintor Pharmaceutical Limited

Source: https://www.prnewswire.com:443/news-releases/kintors-proxalutamide-gt0918-covid-19-clinical-trial-shows-positive-preliminary-results-in-treatment-of-female-patients-301204743.html

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Climate Neutral Data Centre Pact Commits European Cloud and Data Centre Industry To Ambitious Sustainability Action

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BRUSSELS, Jan. 21, 2021 /PRNewswire/ —  One year after the adoption of the European Green Deal, leading cloud infrastructure providers and data centre operators have created the Climate Neutral Data Centre Pact. Twenty-five companies and 17 associations have agreed to a Self Regulatory Initiative to make data centres in Europe climate neutral by 2030. Companies joining the Pact represent the most significant industry players in cloud infrastructure and data centres in Europe.  This is an historic and unprecedented commitment by an industry to proactively lead the transition to a climate neutral economy.

Frans Timmermans, European Commission Executive Vice-President for the European Green Deal: “Citizens across Europe use ever more technology to go about their daily lives and want this technology, also to help secure a sustainable future for people and planet. Today’s pledge from important parts of the data industry constitutes a promise to society and offers a welcome first step towards achieving our common ambitions for a smart and sustainable future.”

Alban Schmutz, Chairman of CISPE (Cloud Infrastructure Services Providers in Europe): “With cloud infrastructure the backbone of the European Union’s digital economy, our industry is committed to the idea that we must all play a central role in addressing climate change. This commitment underpins a roadmap for Europe’s cloud infrastructure industry to offer climate neutral services to customers by 2030.”

Apostolos Kakkos, Chairman of EUDCA (European Data Centre Association): “Data centres are the supporting pillars of the fourth industrial revolution and, as seen during the COVID-19 pandemic, are essential infrastructure of not only the digital economy but of the entire global economy. It is our duty to commit to a self-regulatory initiative that will help to ensure the operational availability, sustainability and the future of our industry.”

The Climate Neutral Data Centre Pact establishes a Self Regulatory Initiative which has been developed in co-operation with the European Commission. It supports both the European Green Deal, which aims to make Europe the world’s first climate neutral continent by 2050, and the European Data Strategy by making EU data centres climate neutral by 2030. The Self Regulatory Initiative sets ambitious goals that will facilitate Europe’s essential transition to a greener economy. It commits signatories to ensuring their data centres are climate neutral by setting ambitious measurable targets for 2025 and 2030 in the following areas:

  • Prove energy efficiency with measurable targets
  • Purchase 100% carbon-free energy
  • Prioritise water conservation
  • Reuse and repair servers
  • Look for ways to recycle heat

Progress towards achieving climate neutral data centres will be monitored by the European Commission twice a year.

For more details on the new Climate Neutral Data Centre Pact, please visit ClimateNeutralDataCentre.net

Signatories:

Cloud providers and operators of data centres

3DS Outscale (Dassault Systèmes)

  • AWS (Amazon Web Services)
  • Digital Realty/Interxion
  • FlameNetworks

Trade associations

 CISPE, the association of Cloud Infrastructure Services Providers Europe

  • EUDCA, the European Data Centre Association
  • Cloud Community Poland
  • Danish Cloud Community
  • Datacenter Industrien
  • Data Centre Alliance
  • Dutch Data Center Association
  • Dutch Hosting Providers Association
  • Eco – Alliance for strengthening digital infrastructures in Germany
  • EuroCloud Croatia
  • EuroCloud France
  • France Datacenter
  • Host in Scotland
  • ISPConnect

Press contact

Simona Romeo

Senior Communication Officer, CISPE

+32 492 24 98 68

[email protected]

CONTACT:

Elisabeth Lennhede

Head of Communications

+46703322705

[email protected]

This information was brought to you by Cision http://news.cision.com

https://news.cision.com/digiplex/r/climate-neutral-data-centre-pact-commits-european-cloud-and-data-centre-industry-to-ambitious-sustai,c3271434

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SOURCE DigiPlex

Source: https://www.prnewswire.com:443/news-releases/climate-neutral-data-centre-pact-commits-european-cloud-and-data-centre-industry-to-ambitious-sustainability-action-301212398.html

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Clear Aligners Market Size Worth $6.0 Billion By 2027 | CAGR: 23.1%: Grand View Research, Inc.

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SAN FRANCISCO, Jan. 21, 2021 /PRNewswire/ — The global clear aligners market size is expected to reach USD 6.0 billion by 2027, expanding at a CAGR of 23.1%, according to a new report by Grand View Research, Inc. Clear aligners are invisible and discreet braces developed from thermoformed materials like copolyester or polycarbonate plastic and CAD 3D printing technology, acting as an alternative to traditional braces. According to the FDA, the clear aligner system helps in positioning the teeth by the means of continuous gentle force and are developed to treat mild to moderate malocclusion. According to WHO, malocclusion is the third most prevalent dental disease after dental caries and periodontal disease globally. Malocclusion of the teeth causes the problem of misalignment which can later lead to severe oral health complications like hard and soft tissue trauma. This condition is hereditary and can be passed from one generation to another.

Key suggestions from the report:

  • The teenage segment emerged as the largest consumer segment in 2019, as teenagers are increasingly opting for the orthodontic device because of its inconspicuous characteristics and comfort
  • The standalone practices segment reciprocated the largest share in 2019 as standalone practitioners are readily adopting the orthodontic device and are equipped with advanced digital technologies
  • North America dominated the market in 2019 owing to increasing demand for new technologies, a large pool of key players, rising prevalence of dental disorders, and advanced healthcare infrastructure in the region
  • In Asia Pacific, the market is expected to reciprocate the highest CAGR over the forecast period.

Read 100 page research report with ToC on “Clear Aligners Market Size, Share & Trends Analysis Report By Age (Adult, Teenage), By End-use (Hospitals, Standalone Practices, Group Practices), By Region, And Segment Forecasts, 2020 – 2027” at: https://www.grandviewresearch.com/industry-analysis/clear-aligners-market

Technological advancements and growing demand for customized clear aligners are significant factors responsible for market growth. Companies like Align Technology and DynaFlex are constantly bringing in newer computer-aided technology in the market. For instance, the launch of iTero, which is a digital impression system, by Align Technology is assisting in developing accurate, effective, and customized clear aligners. The device is designed in accordance with the wearer’s comfort to treat mild to moderate misalignment conditions. According to an article published in Scielo.com in November 2018, the global prevalence of Class I malocclusions is 74.7% and Class II malocclusions are 19.6%. The rising prevalence of these medical conditions is assisting in the escalating the demand for the orthodontic device.

The demand for customized clear aligners has witnessed a burgeoning growth, especially among teenagers. For Instance, the FDA approved, Invisalign clear aligners developed by Align Technology, have been used in the treatment of 5.0 million people as of 2018 and worldwide Invisalign shipments to teenagers were about 87.1 thousand cases. To date, over 1.0 million teenagers have adopted the orthodontic treatment. This is because many teenagers prefer avoiding discomfort caused by the metal braces and also want their braces to look esthetically appealing. The above-mentioned factors are cumulatively assisting in robust market growth.

Grand View Research has segmented the global clear aligners market on the basis of age, end-use, and region:

  • Clear Aligners Age Outlook (Revenue, USD Million, 2016 – 2027)
    • Adult
    • Teenage
  • Clear Aligners End-use Outlook (Revenue, USD Million, 2016 – 2027)
    • Hospitals
    • Stand Alone Practices
    • Group Practices
    • Others
  • Clear Aligners Regional Outlook (Revenue, USD Million, 2016 – 2027)
    • North America
      • The U.S.
      • Canada
    • Europe
      • The U.K.
      • Germany
      • France
      • Spain
      • Italy
    • Asia Pacific
      • India
      • Japan
      • China
      • Australia
      • South Korea
    • Latin America
      • Brazil
      • Mexico
      • Argentina
    • Middle East & Africa
      • South Africa
      • Saudi Arabia
      • UAE

List of Key Players of Clear Aligners Market

  • Align technology
  • Dentsply Sirona
  • Patterson Companies Inc
  • Institute Straumann
  • Danaher Corporation
  • 3M EPSE
  • Argen Corporation
  • Henry Schein Inc.
  • TP Orthodontics Inc.

Find more research reports on  Medical Devices Industry, by Grand View Research:

  • Hip Replacement Implants Market – The global hip replacement implants market size was estimated at USD 5.56 billion in 2018 and is anticipated to grow at a CAGR of 4.7% over the forecast period.
  • Obesity Treatment Market – The global obesity treatment market was valued at USD 3.9 billion in 2015. According to the Institute of Health Metrics and Evaluation, 2.1 billion people are either obese or overweight.
  • Sinus Dilation Devices Market – The global sinus dilation devices market size was estimated at USD 1.79 billion in 2017. It is likely to witness a CAGR of 8.9% during the forecast period.

Gain access to Grand View Compass, our BI enabled intuitive market research database of 10,000+ reports

About Grand View Research

Grand View Research, U.S.-based market research and consulting company, provides syndicated as well as customized research reports and consulting services. Registered in California and headquartered in San Francisco, the company comprises over 425 analysts and consultants, adding more than 1200 market research reports to its vast database each year. These reports offer in-depth analysis on 46 industries across 25 major countries worldwide. With the help of an interactive market intelligence platform, Grand View Research helps Fortune 500 companies and renowned academic institutes understand the global and regional business environment and gauge the opportunities that lie ahead.

Contact:

Sherry James
Corporate Sales Specialist, USA
Grand View Research, Inc.
Phone: 1-415-349-0058
Toll Free: 1-888-202-9519
Email: [email protected]
Web: https://www.grandviewresearch.com
Follow Us: LinkedIn | Twitter 

SOURCE Grand View Research, Inc.

Source: https://www.prnewswire.com:443/news-releases/clear-aligners-market-size-worth-6-0-billion-by-2027–cagr-23-1-grand-view-research-inc-301212250.html

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Acer Releases Pair of New 11-inch Chromebooks for Education

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Editor’s Summary

  • The Acer Chromebook 511 features the Qualcomm® Snapdragon 7c compute platform for powerful, sustained performance and incredible battery life; additionally, secure and reliable 4G LTE connectivity allows for a modern, untethered education experience
  • The Acer Chromebook 311 is a reliable and easy-to-use device aimed at K-12 students, equipped with the MediaTek MT8183 processor
  • All models meet the MIL-STD 810H[1], [2] durability standard and a number of leading toy-safety standards, providing users with the peace-of-mind to focus on what counts: learning

TAIPEI, Jan. 21, 2020 /PRNewswire/ — Acer today announced a pair of new 11-inch Chromebooks for the education market with well-rounded features intended to make it as easy as possible for a school to go digital: military durability standards let parents trust that the devices are reliable, Zero-touch enrollment makes it easy for IT to roll them out, and students will enjoy the intuitive responsiveness of Chrome OS.

Acer Chromebook 511 — Learning Without Borders

The Acer Chromebook 511 (C741L) is an 11.6-inch notebook computer that simplifies the process of establishing a digital learning environment, with a number of features that will benefit both the students using the devices and the school administrators rolling them out. The Qualcomm® Snapdragon 7c compute platform allows for up to 20 hours[3] of battery life between charges on top of offering an efficient performance to keep up with students’ learning needs. Utilizing Snapdragon 7c, the Acer Chromebook 511 also delivers built-in 4G LTE connectivity to help protect the security of users’ data and to provide fast, reliable access to learning apps in the cloud — enabling students to take the classroom with them and learn from virtually anywhere. Weighing in at just 1.3kg (2.87 lbs), this thin and light device is portable enough for students of all ages to easily transport between classes.

Equipped with a MIL-STD 810H[1],[2] tested and impact-resistant chassis, the Acer Chromebook 511 is more than capable of shrugging off daily wear and tear, whether it’s a bump or elbows resting on a desk. The Acer Chromebook 511 also features widened brackets and reinforced I/O ports that help it stand up to rough handling, while a unique drainage system built into its keyboard helps to protect the device’s internals from accidental spills[4]. As a final touch, mechanically anchored keys serve to keep keys where they should be and facilitate easier repairs for IT personnel.

With Zero-touch enrollment, IT departments can drop ship both the Acer Chromebook 511 and Acer Chromebook 311, which will automatically enroll into school administration as soon as the end user connects to the internet.

Acer Chromebook 311 — Built to Survive the School Day

Made especially for K-12 students and those supervising them, the Acer Chromebook 311 (C722) is a reliable device with a MediaTek MT8183 processor designed around a number of industrial durability and safety standards. Compliant with the MIL-STD 810H[1], [2] standard, the device can survive falls of up to 122 cm (48.03 in) and withstand up to 60 kg (132.28 lbs) of downward force, feats accomplished with shock-absorbent bumpers and an enhanced interior design. Special attention was paid to the Chromebook’s keyboard, a uniquely vulnerable area that receives significant wear and tear. It is capable of withstanding up to 330 ml (11.6 fl oz) of water, and its keys have been mechanically anchored with two wings that extend out under the chassis, protecting them from removal by restless hands and sticky fingers.

Striving to create a device that not only was capable of surviving the mishaps of a typical school day but was also suitable for more vulnerable young learners, Acer built the Acer Chromebook 311 (and Acer Chromebook 511) in compliance with a pair of leading toy safety standards. Plastic coatings on the computer have been strictly tested and certified under the ASTM F963-16[5] Toy Safety Standard and the device also meets the UL/IEC 60950-1[6] standard, covering everything from chemical and material safety to sharp edges to ensure that the Acer Chromebook 311 is safe and suitable for use by younger children.

Ultimately, the Acer Chromebook 311 offers durability and peace of mind so that users can spend less time worrying about the device and more about what really matters: learning. The Chromebook features up to 20 hours[3] of battery life so that it’s capable of getting through the school day and back home with young learners. It also includes a number of features to enhance collaborative learning, such as an optional touch screen[7], an HDR webcam with a wide field-of-view for online classes and all the advantages of Chrome OS: quicker boot times, an easy-to-use interface, built-in malware protection, access to millions of Android apps on Google Play, and much more.

App Support

The new Acer Chromebook 511 and Acer Chromebook 311 both support apps via Google Play and web based apps, so customers will have access to all the apps they love for productivity, creativity, services and more.

Pricing and Availability

The Acer Chromebook 511 (C741L) will be available in North America in April starting at USD 399.99; and in EMEA in March starting at EUR 399.

The Acer Chromebook 311 (C722) will be available in North America in January starting at USD 299.99; and in EMEA in March starting at EUR 269.

Exact specifications, prices, and availability will vary by region. To learn more about availability, product specifications and prices in specific markets, please contact your nearest Acer office via www.acer.com.

[1] Sand and Dust testing based on MIL-STD 810F.

[2] Tested by qualified 3rd party labs for certain tests procedure under MIL-STD 810H for environmental conditions that include high and low temperatures, humidity, vibrations, mechanical shocks on drops, rain, dust and sand.

[3] Battery life may vary depending on model and configuration. Based on Google power_LoadTest. Up to 20 hours with 48 Wh battery, and up to 15 hours with 36Wh battery

[4] Up to 330 ml (11 fluid ounces) of water

[5] Plastic coatings used on Acer Chromebook Spin 311 surface have been strictly tested and certified under ASTM F963-16 Toy Safety Standard and Consumer Product Safety Improvement Act (CPCIA) of 2008. For more information visit: https://standardscatalog.ul.com/standards/en/standard_60950-1_2

[6] Acer Chromebook Spin 311 is designed and tested to meet UL/IEC 60950-1 safety standard, investigated by UL 696 safety electric toys and meets the ASTM F963 toy safety for kids over 3 years old. For more information visit: https://www.astm.org/Standards/F963.htm

[7] Specifications may vary depending on model and/or region.

About Acer

Established in 1976, Acer is a hardware + software + services company dedicated to the research, design, marketing, sale, and support of innovative products that enhance people’s lives. Acer’s product offerings include PCs, displays, projectors, servers, tablets, smartphones and wearables. It is also developing cloud solutions to bring together the Internet of Things. Acer celebrated its 40th anniversary in 2016 and is one of the world’s top 5 PC companies. It employs 7,000 people worldwide and has a presence in over 160 countries. Please visit www.acer.com for more information.

© 2021 Acer Inc. All rights reserved. Acer and the Acer logo are registered trademarks of Acer Inc. Celeron, Intel and the Intel logo are trademarks of Intel Corporation or its subsidiaries in the U.S. and/or other countries. Qualcomm and Snapdragon are trademarks or registered trademarks of Qualcomm Incorporated. Qualcomm Snapdragon is a product of Qualcomm Technologies, Inc. and/or its subsidiaries. Other trademarks, registered trademarks, and/or service marks, indicated or otherwise, are the property of their respective owners. All offers subject to change without notice or obligation and may not be available through all sales channels. Prices listed are manufacturer suggested retail prices and may vary by location. Applicable sales tax extra.

SOURCE Acer

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http://www.acer.com

Source: https://www.prnewswire.com:443/news-releases/acer-releases-pair-of-new-11-inch-chromebooks-for-education-301212393.html

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First Hotels Partners with RateGain for AI-enabled Competitive Intelligence and Rate Parity

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LONDON, Jan. 21, 2021 /PRNewswire/ — RateGain Technologies, the leading SaaS Company for travel and hospitality, today announced a global strategic partnership with First Hotels, a leading hotel chain in Scandinavia, for providing AI-driven competitive pricing insights and helping maintain price parity across various OTAs and third-party booking platforms.

First Hotels required a comprehensive solution that makes it easy for its revenue management team to not only make daily pricing decisions but also monitor the market effectively. RateGain’s rate intelligence suite powered by Parity+ and OPTIMA will allow First Hotels to configure smart rate shopping leveraging an AI-powered data platform while tracking real-time parity with features such as advanced KPI dashboards coupled with automated alerts that help in closing the loops with violators, checking revenue leakage, saving time and driving costs down.

Together with MarketDRONE that leverages AI to track intra-day rate changes as well as the AI-driven dataSURE, First Hotels would get >99% data sufficiency and accuracy to adjust prices in real-time based on competitive insights than can be refreshed in less than 60 seconds.

All this served through an easy to use interface, the revenue team at First Hotels would be able to get a consolidated view of properties to track the market positioning of the subscriber easily as well as see what their customers are viewing irrespective of the geography from which the OTA or Meta is accessed.

“We have been searching for a partner that can make it easier for our managers and central resources to formulate the pricing strategy. RateGain’s Optima and Parity+ offers a fantastic AI-empowered dynamic setup. It will enable First Hotels to acclimatize to any competitive ecosystem and make good pricing and rate distribution decisions. As such, after evaluating multiple service providers, we were confident that RateGain understands our needs and would be the best partner for us,” said Pontus Mark, Director of Revenue Management, First Hotels.

Commenting on the partnership,Mark Haywood, SVP & Head of Europe, RateGain Technologies, said, “At RateGain,our goal is to unlock new revenue using AI-led products which enable our partners to take better control of their pricing strategy. Optima’s easy to use UI and the ability to deliver real-time actionable insights would help First Hotels with day-to-day pricing decisions.In addition,Parity will be accretive as it identifies channels or properties facing maximum revenue loss due to parity issues. Together, Optima and Parity+ will help First Hotels maximize their revenue.”

About RateGain

RateGain is a leading provider of SaaS products, which help travel and hospitality companies with cognitive revenue management, smart e-distribution, and brand engagement to make more revenue every day. For more information,visit https://rategain.com

About First Hotels

First Hotels is a leading collection of hotels with 33 unique hotels centrally located in Sweden, Norway, Denmark. First Hotels is proud to offer unique, personal service and modern comfort. First Hotels was established in 1993 and initially comprised six hotels located in Sweden.To know more visit https://www.firsthotels.com/

Media Contact:

Ankit Chaturvedi
AVP-Marketing
[email protected]

Logo : https://mma.prnewswire.com/media/923440/RateGain_Logo.jpg

SOURCE RateGain

Source: https://www.prnewswire.com:443/news-releases/first-hotels-partners-with-rategain-for-ai-enabled-competitive-intelligence-and-rate-parity-871974520.html

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