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Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase

Date:

Nature Nanotechnology, Published online: 05 August 2021; doi:10.1038/s41565-021-00952-x

Understanding the fundamental nano–bio interactions of nanomaterials intended for biomedical use might unlock potential alternative applications. Here the authors reveal a tumoricidal mechanism of black phosphorus nanomaterials where these nanomaterials directly affect the mitotic centrosome machinery by suppressing polo-like kinase 1, suggesting that nanomaterials can be applied in targeted cancer therapy with their intrinsic nano–bio properties.
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Source: https://www.nature.com/articles/s41565-021-00952-x

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