Although ZnO nanoparticles possess novel properties that make them available to a vast range of applications, the questions regarding their safety arise when it comes in contact with the biological systems (such as skin, lungs and tissues). In this study, we evaluated the possible toxicology effects of different dosage of zinc oxide nanoparticles (with quantities of 25, 50 and 100 mg/kg of nano solution) in three treatments for four consecutive weeks on skin and muscle tissues of rats (n= 40; weight: 150-200 g) compared with the control samples and the results were analyzed by one-way analysis of variance (ANOVA).
The results showed that the use of zinc oxide did not have much effect on skin and skeletal muscle tissue of rats. Although, we did not find any harm to the skin and musculoskeletal system in the use of different dosage of zinc oxide nanoparticles in this study, but we can not ignore the reports of the sensitivity of cells and tissues to potentially cytotoxic nanoparticles. Therefore, it is suggested that further, wider and stronger research should be paid on the complex mechanism of toxicity of zinc oxide nanoparticles in living systems.