(Labaran NanowerkSakamakon gwaji na gwaji na gwaji na biyu na asibiti a Cibiyar Kiwon Lafiya ta Kudu maso Yamma ta UT ya nuna cewa dakatar da nanocrystals na zinare da marasa lafiya da ke fama da cutar sclerosis (MS) da cutar Parkinson (PD) suka yi amfani da su a kowace rana sun sake juyar da gazawar metabolites da ke da alaƙa da aikin kuzari a cikin kwakwalwa kuma ya haifar da hakan. inganta aikin. Sakamakon binciken, wanda aka buga a cikin Jaridar Nanobiotechnology ("Shaidar da aka yi niyya a cikin kwakwalwa a cikin cutar Parkinson da sclerosis da yawa ta binciken nanomedicine, CNM-Au8, a cikin gwajin gwaji na asibiti na 2 REPAIR"), a ƙarshe zai iya taimakawa wajen kawo wannan magani ga marasa lafiya da waɗannan da sauran cututtuka na neurodegenerative, a cewar marubuta. Nanocrystals na zinari da aka dakatar a cikin buffer ruwa suna wakiltar wani sabon maganin warkewa wanda Clene Nanomedicine ya haɓaka don yanayin neurodegenerative. Ana binciken wannan nanomedicine, wanda ake kira CNM-Au8, don kula da marasa lafiya masu fama da sclerosis da cutar Parkinson a gwajin asibiti a UT Kudu maso yammacin. (Hoto: Random 42/Source: Clene Nanomedicine) "Muna da kyakkyawan fata cewa za mu iya hana ko ma mu juya wasu nakasassu na jijiyoyi tare da wannan dabarun," in ji Peter Sguigna, MD, wanda ke jagorantar gwajin MS mai aiki kuma Mataimakin Farfesa na Neurology kuma mai bincike a cikin Peter O'Donnell Jr. Cibiyar Brain a UT Southwestern. Lafiyayyen aikin kwakwalwa ya dogara ne akan ci gaba da samar da kuzari ga wannan kwayoyin halitta ta kwayoyin halitta da ake kira adenosine triphosphate (ATP), Dr. Sguigna yayi bayani. Shekaru yana haifar da raguwa a cikin makamashi na kwakwalwa, wanda ya bayyana a cikin raguwa a cikin rabo na nicotinamide adenine dinucleotide (NAD +) da abokin tarayya, nicotinamide adenine dinucleotide + hydrogen (NADH). Duk da haka, binciken ya nuna cewa a cikin yanayin neurodegenerative irin su MS, PD, da kuma amyotrophic lateral sclerosis (ALS) - wanda kuma aka sani da cutar Lou Gehrig - wannan raguwa a cikin NAD +/NADH rabo ya fi sauri kuma ya fi tsanani. Nazarin a cikin sel, nau'ikan dabbobi, da marasa lafiyar ɗan adam sun ba da shawarar cewa dakatarwa ko jujjuya wannan ƙarancin kuzari na iya haifar da raguwar raguwa ko ma murmurewa ga marasa lafiya da cututtukan neurodegenerative, Dr. Sguigna yace. A ƙarshen wannan, shi da abokan aikinsa sun yi haɗin gwiwa tare da Clene Nanomedicine, wani kamfani da ke haɓaka nanocrystals na zinariya a cikin wakili na maganin warkewa na baki don yanayin neurodegenerative, ciki har da maganin gwaji mai suna CNM-Au8. Wadannan nanocrystals suna aiki a matsayin masu haɓakawa waɗanda ke haɓaka ƙimar NAD +/NADH, da kyau suna canza ma'aunin kuzarin sel na kwakwalwa - lamarin da aka nuna a cikin salon salula da ƙirar dabba a cikin binciken da suka gabata. Don sanin ko CNM-Au8 ya kai ga manufar da aka yi niyya a cikin marasa lafiya na mutum, masu bincike na UTSW sun dauki nauyin mahalarta 11 tare da sake dawowa MS da 13 tare da Parkinson na biyu na gwaji na asibiti na biyu, REPAIR-MS da REPAIR-PD. Waɗannan mahalarta sun sami na'urar sikelin sikelin ƙwalƙwalwar ƙwaƙwalwa ta farko (MR) don tantance tushen asalin NAD +/NADH da matakan sauran ƙwayoyin cuta masu alaƙa da haɓakar kuzarin tantanin halitta. Bayan sun ɗauki kashi na yau da kullun na CNM-Au8 na makonni 12, gwaji ya haɗa da na biyu MR spectroscopy. Tare, marasa lafiya na 24 sun sami matsakaicin haɓaka a cikin ƙimar NAD +/NADH na 10.4% idan aka kwatanta da tushe, yana nuna cewa CNM-Au8 yana yin niyya ga kwakwalwa kamar yadda aka yi niyya. Sauran ƙwayoyin kuzari masu ƙarfi, gami da ATP, waɗanda aka daidaita zuwa ƙungiyar suna nufin ƙarshen jiyya, wani tasiri mai fa'ida. Yin amfani da ingantaccen bincike don sakamakon aiki a cikin PD, masu bincike sun gano cewa nazarin marasa lafiya da wannan yanayin sun ruwaito inganta "ƙwarewar motsi na rayuwar yau da kullum" a wani lokaci, yana nuna cewa shan CNM-Au8 zai iya inganta alamun aikin cutar su. Babu ɗayan marasa lafiyan da ya sami mummunan sakamako masu illa masu alaƙa da CNM-Au8. Yayin da waɗannan sakamakon ke ƙarfafawa, ana buƙatar ƙarin karatu, Dr. Sguigna yace.

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• Source: https://www.nanowerk.com/nanotechnology-news3/newsid=64649.php