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G1 Therapeutics to Provide Second Quarter 2020 Corporate and Financial Update on August 5, 2020

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RESEARCH TRIANGLE PARK, N.C., July 29, 2020 (GLOBE NEWSWIRE) — G1 Therapeutics, Inc. (Nasdaq: GTHX), a clinical-stage oncology company, today announced that it will host a webcast and conference call to provide a corporate and financial update for the second quarter of 2020 on Wednesday, August 5, 2020 at 5:00 p.m. ET.

The live call may be accessed by dialing 866-763-6020 (domestic) or 210-874-7713 (international) and entering the conference code: 4648036. The live and archived webcast will be available on the Events & Presentations page of the G1 website.

About G1 Therapeutics
G1 Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on the discovery, development and delivery of innovative therapies that improve the lives of those affected by cancer. The company is advancing three clinical-stage programs. Trilaciclib is a first-in-class FDA-designated Breakthrough Therapy designed to improve outcomes for patients being treated with chemotherapy. Rintodestrant is a potential best-in-class oral selective estrogen receptor degrader (SERD) for the treatment of ER+ breast cancer. Lerociclib is a differentiated oral CDK4/6 inhibitor designed to enable more effective combination treatment strategies.

G1 Therapeutics is based in Research Triangle Park, N.C. For additional information, please visit www.g1therapeutics.com and follow us on Twitter @G1Therapeutics.

Contact:
Jeff Macdonald
Senior Director, Investor Relations & Corporate Communications
919-907-1944
jmacdonald@g1therapeutics.com

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Source: https://www.biospace.com/article/releases/g1-therapeutics-to-provide-second-quarter-2020-corporate-and-financial-update-on-august-5-2020/?s=75

Biotechnology

Benefits of Purchasing Used Lab Equipment

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In the laboratory industry, there can be a lot of pressure to always have the newest and latest technology. Due to concerns about having outdated or inefficient equipment, many professionals don’t even consider purchasing used equipment. However, there are numerous advantages to doing so. Here are some of the key benefits of purchasing used lab equipment to keep in mind next time you need to purchase equipment.


Financial Benefits

One of the most significant and obvious benefits of purchasing used lab equipment is that doing so can save you a lot of money. Used laboratory equipment is significantly less expensive than brand new models. Often laboratories can save up to 50 percent or more by purchasing quality second-hand equipment.

Because laboratory equipment is often one of the top expenses that laboratories incur, purchasing used can substantially reduce laboratory costs and free up some much-needed room in tight budgets.

 

Environmental Benefits

Large laboratory equipment can take up a lot of room in landfills and often contain toxic components such as lead or mercury. Such toxins can seep into the earth and contaminate groundwater over time. By purchasing used laboratory equipment rather than new, you can reduce the amount of equipment that ends up in landfills. Plus, you will also reduce the number of raw materials used to manufacture new equipment which will decrease your lab’s negative impact on the environment.

Increased Insight

Purchasing a new type of equipment right after it is released comes with some risks. When a piece of equipment is fresh on the market, there aren’t many reviews from past customers attesting to how well or poorly it operates.\

Used equipment, however, is far less risky. Because the equipment has been on the market for a while, there are likely plenty of reviews that you can reference and any potential issues have likely been well-documented. Just make sure to purchase from a reliable and trustworthy reseller that took the proper measures to ensure the equipment is in optimal operating condition.

Reduced Wait Time

If you need a piece of equipment in a short period of time, buying used is often the best option. Many manufacturers have long wait times that can require you to wait for several weeks or even months before the equipment will arrive. If you have deadlines you need to meet, that simply won’t do. In cases when you need equipment in a timelier manner, used equipment is already built and ready to go so you often only have to wait for shipping.


 

Source: Christina Duron is a freelance writer for multiple online publications where she can showcase her affinity for all things digital. She has focused her career around digital marketing and writes to explore topics that spark her interest.

 

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Biotechnology

CYIOS CORP’S RECEIVES APPROVAL TO SELL ITS SANITIZER PRODUCTS ON AMAZON.COM

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Deerfield Beach, Florida, November 23, 2020 – OTC PR WIRE — CYIOS Corp. (OTC US: CYIO), a publicly traded company focused on developing and marketing specialty branded products in the Health and Wellness markets, is pleased to announce it has received approval from Amazon to sell various My-shield sanitizing products in Amazon’s Personal Safety and Household category.  Products to be sold on Amazon.com will include the My-shield triple play sanitizing products which have recently undergone clinical studies for effectiveness including My Shield Hand Sanitizer, My-shield Surface Cleaner and My-shield Laundry Complete.  Clinical data from these studies conducted on this trio of My-shield sanitizing products have shown long lasting sanitizer protection and effectiveness against a surrogate virus for SARS-CoV-2 on skin, hard surfaces, fabrics and clothes.

John O’Shea CYIO’s Chairman stated, “We are pleased to have received this approval to sell various My-shield sanitizing products in Amazon’s Personal Safety and Household category.  Our strategy continues to be on developing market and distribution opportunities around a Triple Play of sanitizing products which have recently undergone clinical studies for effectiveness including My Shield Hand Sanitizer, My-shield Surface Cleaner and My-shield Laundry Complete. During the six week period of time we had to undergo for the approval process within this product category, several of the My-shield Zetrisl® based sanitizer products had completed lengthy clinical testing in a laboratory setting and showed effectiveness against a CDC recognized surrogate virus for SARS-CoV-2 on skin, hard surfaces, fabrics and clothes.  Results of which are posted here:  Zetrisil-The-Total-Covid-19-Solution

Approval on Amazon gives the Company an additional platform for selling direct to consumers, which complements our recently announced launch with RangeMe giving us direct access to thousands of retail purchasing managers on their B2B platform. As we enter the holiday season, keep an eye out for valuable holiday specials, product marketing and advertising on the My-shield Triple Play and our “24” Brand Hand sanitizer which is also Zetrisl® powered.  We believe giving the gift of safety and security with these long-lasting clinically proven sanitizers for effectiveness is a terrific and thoughtful holiday gift”.

About Zetrisil: Zetrisil®-based technologies are a family of proprietary silicon-based virus killing agents that reduce the presence of the virus from the hands, hard surfaces, fabric and most clothing environments.  Zetrisil® effectively protects and/or “shields” the area that “24” Brand hand sanitizer and My-shield products are applied to from bacterial contamination for an extended period of time after application. Made with non-alcohol, Benzalkonium Chloride (BZK), My-shield® and 24 Brand sanitizers are a safer alternative to Alcohol-based hand sanitizers which can be absorbed into the bloodstream, are flammable, and are only proven effective for a few minutes after each application.  These factors make traditional alcohol-based hand sanitizers a less than optimal choice particularly for families with children and/or for those out and about in public.  Because Zetrisil® is safer than traditional agents and remains on the skin for several hours, people are protected longer without the need for frequent applications of sanitizer ― all without the toxicity and flammability concerns of alcohol-based sanitizers.  The recent clinical testing data is powerful and proven evidence of the effectiveness of these products.

CONTACT INFORMATION

info@choicewellnessbrands.com

Investors are encouraged to follow CYIOS using:

www.twitter.com/cyioscorp

https://www.instagram.com/choicewellnessbrands/

https://www.linkedin.com/company/choice-wellness

https://www.facebook.com/choicewellnessbrands/

About ChoiceWellness, Inc:

ChoiceWellness, Inc. is a health and wellness company that has brought to market the DR’s CHOICE line of products, as well as the “24” Brand Hand Sanitizer products.  DR’s CHOICE was developed with a mission to offer Doctors and Medical Practitioners their own Professional Grade CBD BRAND with a suite of products they could stand behind and be confident to offer to their patients.  Our customers can be assured that DR’s CHOICE CBD products have gone through the highest scrutiny of testing for purity, potency and quality. DR’s Choice products have been brought to market for Doctors and Medical Professionals seeking a better solution for patients suffering from pain, inflammation, anxiety or other persistent symptoms.  For more information please visit www.choicewellnessbrands.com

About CYIOS Corporation

CYIOS Corporation is a publicly traded company focused on developing and marketing specialty branded products in the Health and Wellness markets, including the “DR’s CHOICE” and “24” brand of products. The team has in-depth knowledge of the health and wellness markets, financial services industry, medical and health services, and blockchain. The Company looks to develop, distribute, and license proprietary products as well as evaluate potential acquisition opportunities. Further, the Company continues to seek and evaluate attractive business opportunities and to leverage its resources and expertise to build a diversified, sustainable business model.  For more information please visit www.cyioscorporation.com

FORWARD-LOOKING STATEMENTS: This release contains “forward-looking statements.” Forward-looking statements also may be included in other publicly available documents issued by the Company and in oral statements made by our officers and representatives from time to time. These forward-looking statements are intended to provide management’s current expectations or plans for our future operating and financial performance, based on assumptions currently believed to be valid. They can be identified by the use of words such as “anticipate,” “intend,” “plan,” “goal,” “seek,” “believe,” “project,” “estimate,” “expect,” “strategy,” “future,” “likely,” “may,” “should,” “would,” “could,” “will” & other words of similar meaning in connection with a discussion of future operating or financial performance. Examples of forward-looking statements include, among others, statements relating to future sales, earnings, cash flows, results of operations, uses of cash and other measures of financial performance. Because forward-looking statements relate to the future, they are subject to inherent risks, uncertainties and other factors that may cause the Company’s actual results and financial condition to differ materially from those expressed or implied in the forward-looking statements. Such risks, uncertainties and other factors include, among others such as, but not limited to economic conditions, changes in the laws or regulations, demand for products and services of the company, the effects of competition and other factors that could cause actual results to differ materially from those projected or represented in the forward-looking statements. Any forward-looking information provided in this release should be considered w/ these factors in mind. We assume no obligation to update any forward-looking statements contained in this report.

Source: https://otcprwire.com/cyios-corps-receives-approval-to-sell-its-sanitizer-products-on-amazon-com/

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Biotechnology

Umbra Companies, Inc. Announces the Acquisition of H2O Processing

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Tampa, FL, November 19, 2020 – OTC PR WIRE – Umbra Companies, Inc. (OTC: UCIX) announced today that it has initiated the acquisition of the Denver, Colorado based manufacturer of water treatment components company H2O Processing.

Chief Executive Officer, Alex Umbra commented, “H2O represents an evolution in water treatment technology commensurate with the growing environmental demands of modern times. What Stan and his team at H2O have developed is exceptionally dynamic and will result in a paradigm shift within the segment. This addition to our suite of companies supports our commitment to building value within our subsidiary structure and delivering improved shareholder value”.

H2O Processing is a manufacturing, research and engineering company, that has been operating within the water treatment space for 30 years in varying capacities. With an expanding portfolio of intellectual property, the H2O team has just recently begun its expansion into a full-provider and manufacturer of mobile on-site and fixed water treatment platforms.

The company’s mobile water treatment platform concluded field testing and certification within the past five years and has been awarded the only state-wide permit in all 77 counties within Oklahoma to treat deleterious water to non-deleterious water. The mobile platforms are fully automated and can be managed remotely by either H2O Processing from their headquarters in Denver or managed by the customers onsite team. The mobile platform is ready for commercial production and introduction into the market.

H2O Processing CEO stated, “we are aware of more than 2 trillion gallons of water that need to be treated in the United States daily.  This is a tremendous market that will require new water treatment equipment on a large scale.  We want to be in a position to supply this equipment with our associate company Processing Engineering, Inc so that we can further enhance our relationship with UCI. This path forward will allow H2O the capability of meeting the future demands as a “green” company”.

For more information about H2O Processing go here: https://h2otechnologiesinc.com/

About Umbra Companies, Inc.:

The firm is located in Tampa Florida and focuses on advanced technologies across many disciplines. UCI is an investment holding company that invests in both public and private companies during the early stages of development as well as growth stages of companies with a synergistic business model to UCI subsidiaries. For more information visit www.umbracompanies.com

NEITHER THE SECURITIES EXCHANGE COMMISION NOR ITS REGULATION SERVICES PROVIDER ACCEPTS RESPONSIBILITY FOR THE ADEQUACY OR ACCURACY OF THIS NEWS RELEASE.

Forward-Looking Information

This news release may include “forward-looking statements” including forecasts, estimates, expectations, and objectives for future operations including but not limited to its ability to conclude a business combination with a third party, sale of assets, return of capital or initial public offering and a secondary listing on the OTC as a result of aforementioned and its ability to fund the exploration of its assets through the raising of equity or debt capital or through funding by a joint venture partner that are subject to a number of assumptions, risks, and uncertainties, many of which are beyond the control of Umbra Companies, Inc. including but not limited to capital markets and securities risks and continued development success on technology. There can be and are no actual or implied guarantees that any of the above activities will be completed or completed on terms acceptable to the Company and its shareholders or approved by any regulatory authority having jurisdiction. Such forward-looking information represents management’s best judgment based on information currently available. No forward-looking statement can be guaranteed and actual future results may vary materially. Risks and uncertainties about Umbra Companies, Inc. business are more fully discussed in the company’s disclosure materials, including its MD&A, filed with the securities regulatory authorities in Canada and available at www.sedar.com and readers are urged to read these materials. Umbra Companies, Inc. does not assume the obligation to update any forward-looking statement, except as required by applicable law.

Contact:

info@umbracompanies.com

Source: https://otcprwire.com/umbra-companies-inc-announces-the-acquisition-of-h2o-processing/

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Newly discovered enzyme helps make valuable bioactive saponins

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Osaka University-led research team discovers new enzyme, opening novel routes for producing a family of valuable chemicals with medical and food uses

Osaka, Japan – Many plants, including legumes, make naturally occurring chemicals called saponins. For example, the medicinal plant licorice produces the saponin glycyrrhizin, a potent natural sweetener that also has antiviral and other pharmacological activity. Soyasaponins, found in soybeans, have anticarcinogenic and antioxidant properties.

But exactly how plants make these useful products was unclear. Now a research team at Osaka University, in collaboration with National Agriculture and Food Research Organization (NARO), RIKEN, and Chiba University, has uncovered a vital link in the complex biochemical pathway for saponin synthesis. Their discovery paves the way for improving the commercial production of these high-value products. The team recently published the study in Nature Communications.

Osaka University researchers Soo Yeon Chung and Hikaru Seki, with collaborators in NARO (Masao Ishimoto et al.), RIKEN, and Chiba University, studied co-expression gene network of saponin synthesis using technologies including gene cloning and sequence comparisons, coupled with biochemical analyses in mutants and genetically modified plants of a model legume species. They discovered a new enzyme in the CSyGT family that are similar in structure to the enzymes producing cellulose in plant cell walls. Unexpectedly, they showed that the new member of the family was responsible for a key step in saponin synthesis, where a sugar molecule is attached to the triterpenoid backbone. This discovery challenged the generally accepted view that a different class of enzyme was probably involved in this step.

They went on to insert the gene for the newly discovered CSyGT enzyme, along with genes for other steps in the biochemical pathway, into yeast cells. The engineered cells successfully produced glycyrrhizin from simple sugars, indicating a potential route for industrial manufacture of valuable saponins by growing yeast cells on a large scale.

“Our multi-disciplinary team showed, for the first time, that this type of enzyme is important in saponin synthesis,” says corresponding author Toshiya Muranaka. “Our results fill a gap in previous knowledge and also challenge the accepted view of how this pathway for biosynthesis operates.”

“We showed that yeast cells can make glycyrrhizin when we insert the necessary plant genes,” explains Chung. “This offers the prospect of new ways to produce these valuable substances commercially, and to generate completely novel types of saponin that might have further beneficial applications in medicine or the food industry.” Seki adds, “producing the chemicals in cell cultures would also reduce the need to deplete natural plant resources and so help to meet the vitally important Sustainable Development Goals.”

###

The article, “A cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis,” was published in Nature Communications at DOI: https://doi.org/10.1038/s41467-020-19399-0

About Osaka University

Osaka University was founded in 1931 as one of the seven imperial universities of Japan and is now one of Japan’s leading comprehensive universities with a broad disciplinary spectrum. This strength is coupled with a singular drive for innovation that extends throughout the scientific process, from fundamental research to the creation of applied technology with positive economic impacts. Its commitment to innovation has been recognized in Japan and around the world, being named Japan’s most innovative university in 2015 (Reuters 2015 Top 100) and one of the most innovative institutions in the world in 2017 (Innovative Universities and the Nature Index Innovation 2017). Now, Osaka University is leveraging its role as a Designated National University Corporation selected by the Ministry of Education, Culture, Sports, Science and Technology to contribute to innovation for human welfare, sustainable development of society, and social transformation.

Website: https://resou.osaka-u.ac.jp/en/top

Source: https://bioengineer.org/newly-discovered-enzyme-helps-make-valuable-bioactive-saponins/

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