Early outpatient treatment is the most effective for treatment of coronavirus patients, according to a new study published in American Journal of Epidemiology. The study, which was led by Dr. Harvey A Risch of Yale University, suggests that late stage studies missed the point about effective usage of hydroxychloroquine. Dr. Risch says immediate and early ramping-up of treatment for high-risk COVID-19 patients is key to controlling the coronavirus pandemic crisis.
We’ve learned a lot about the virus since coronavirus started in Wuhan, China in December 2019. To date, more than 4,498,343 million Americans have been infected with SARS-CoV-2 and >10 times that number carry antibodies to it. High-risk patients presenting with progressing symptomatic disease have only hospitalization treatment with its high mortality.
According to the study, Dr. Risch said an outpatient treatment that prevents hospitalization is desperately needed. “Remdesivir has shown mild effectiveness in hospitalized inpatients, but no trials have been registered in outpatients. Hydroxychloroquine+azithromycin has been widely misrepresented in both clinical reports and public media, and outpatient trials results are not expected until September,” Dr. Risch said.
In a 29-page report, the study suggests that early outpatient illness is very different than later hospitalized florid disease and the treatments differ. Evidence about use of hydroxychloroquine alone, or of hydroxychloroquine+azithromycin in inpatients, is irrelevant concerning efficacy of the pair in early high-risk outpatient disease.
Five studies, including two controlled clinical trials, have demonstrated significant major outpatient treatment efficacy. Hydroxychloroquine+azithromycin has been used as standard-of-care in more than 300,000 older adults with multicomorbidities, with estimated proportion diagnosed with cardiac arrhythmias attributable to the medications 47/100,000 users, of which estimated mortality is <20%, 9/100,000 users, compared to the 10,000
The great majority of infected people are at low risk for progression or will manifest the infection asymptomatically. For the rest, outpatient treatment is required that prevents disease progression and hospitalization. Exposures will occur as isolation policies are lifted and people begin to mix, even with various degrees of public isolation such as mask usage and physical separation still in place. Thus, the key to returning society toward normal functioning and to preventing huge loss of life, especially among older individuals, people with comorbidities, African Americans and Hispanics and Latinos, is a safe, effective and proactive outpatient treatment that prevents ORIGINAL hospitalization in the first place.
In reviewing the current evidence, Dr. Risch said this:
Based on laboratory and other preliminary evidence to-date, among many others, two candidate medication regimens have been widely discussed for outpatient treatment: remdesivir (Gilead Sciences, Inc., Foster City, California), and hydroxychloroquine (HCQ) plus azithromycin (AZ). Remdesivir has been studied extensively in laboratory work and in animals (8) and for other viral diseases and has good biological properties, suggesting utility for SARSCoV-2 infection. In a study of remdesivir compassionate use in 53 hospitalized patients with severe disease (9), 13% died, which appears lower than what might have been expected without treatment, though greater than the deaths in the placebo arm of the Adaptive COVID-19 Treatment Trial (more below).
Dr. Risch went on to talk about hydroxychloroquine and said this:
The other suggestion is the combined regimen of HCQ+AZ (or its variant HCQ+doxycycline). The FDA has recently issued guidance (15) to physicians and the general public advising that the combination HCQ+AZ should not generally be used except by critically ill hospital inpatients or in the context of registered clinical trials. The NIH panel for Covid-19 treatment guidelines say essentially the same (16), and a similar statement has been released by the major cardiology societies (17). Numerous reviews of HCQ efficacy and adverse events have been and continue to be published. To my knowledge, all of these reviews have omitted the two critical aspects of reasoning about these drugs: use of HCQ combined with AZ or with doxycycline, and use in the outpatient setting. For example, the Veterans’ Administration Medical Centers study (18) examined treated hospitalized patients and was fatally flawed (19). The same point about outpatient use of the combined medications has been raised by a panel of distinguished French physicians (20) in petitioning their national government to allow outpatient use of HCQ+AZ. It appears that the FDA, NIH and cardiology society positions have been based upon theoretical calculations about potential adverse events and from measured physiologic changes rather than from current real-world mortality experience with these medications and that their positions should be revised.
In reviewing all available evidence about hydroxychloroquine, Dr. Risch said this:
In reviewing all available evidence, I will show that HCQ+AZ and HCQ+doxycycline are generally safe for short-term use in the early treatment of most symptomatic high-risk outpatients, where not contraindicated, and that they are
effective in preventing hospitalization for the overwhelming majority of such patients. If these combined medications become standard-of-care, they are likely to save an enormous number of lives that would otherwise be lost to this endemic disease.
Dr. Risch concluded with the following:
I conclude that HCQ+AZ and HCQ+doxycycline, preferably with zinc (47) can be this outpatient treatment, at least until we find or add something better, whether that could be remdesivir or something else. It is our obligation not to stand by, just “carefully watching,” as the old and infirm and inner city of us are killed by this disease and our economy is destroyed by it and we have nothing to offer except high-mortality hospital treatment. We have a solution, imperfect, to attempt to deal with the disease. We have to let physicians employing good clinical judgement use it and informed patients choose it. There is a small chance that it may not work. But the urgency demands that we at least start to take that risk and evaluate what happens, and if our situation does not improve we can stop it, but we will know that we did everything that we could instead of sitting by and letting hundreds of thousands die because we did not have the courage to act according to our rational calculations.
“Americans now dying each week. These medications need to be widely available and promoted immediately for physicians to prescribe,” the study concludes.
The full report can be found at Oxford University Press website
Demisexual: everything you need to know about it.
What does being demisexual mean?
Sexuality refers to how a person experiences sexual and romantic attraction and their interests and preferences regarding it. It is important to observe one’s liking in order to understand yourself efficiently and to discuss it with your partner. Familiarising with the different kinds of sexual orientation can help to navigate and understand the different ways through which people experience their sexuality. A person’s sexuality can be of any type like heterosexual, homosexual, asexual, demisexual etc. It is easier to view it as a spectrum and not a particular category.
Demisexual individuals are people who need to establish a secure emotional connection before they can feel a sexual attraction. The emotional bond does not only include a romantic relationship. It could also be a platonic friendship that makes the demisexual person develop a sexual interest. It is essential to know how being a demisexual feels like. Such individuals can only have a sexual attraction to a tiny group of people.
Demisexuals and heterosexuals
While getting to know about demisexual people, a lot of confusion may arise between their similarities with heterosexuals. Many of us wait long enough to feel a vital connection with a person before engaging in sexual relations with them. It is something that our community tells us as we grow up – to engage in sexual relations only with individuals that you have a bond with. Whether it is – marriages, love affairs or friends with benefits relationships, we usually try to build trust before getting close with them. What makes a demisexual person different is that their sexual attraction is not a choice that they can make.
We abstain from having sex with someone, whereas demisexual people are unable to do it without an emotional connection. Demisexual individuals are not just individuals who choose to date somebody for quite a while before engaging in sexual relations with them. It has no connection with wanting to have intercourse but about feeling sexually interested in someone. For them, it is about the capacity to feel sexual passion towards certain individuals. Heterosexual people can have sex with people that they do not feel a sexual attraction for. Similarly, you can be sexually attracted to someone and not do anything about it.
Demisexual people are unable to have a sexual passion for someone until they develop an emotional connection. That does not mean that all emotional associations lead to a sexual relationship. Just like heterosexuals cannot be sexually attracted to every person they meet, demisexual cannot be attracted to every person that they have a deep connection with. Even though that is the case, some demisexual individuals may decide to hold up some time before engaging in sexual relations with an emotional partner.
Demisexual, Asexual and Graysexual
There has always been a lot of complication between the various categories of sexualities. It is quite natural to mistake between demisexual, asexual and graysexual. To understand what makes these terms different, you need to know what each of them means. Sexual attraction indicates how somebody feels aroused by another person. An asexual individual encounters practically zero sexual fascination. The term that is the exact contrary to asexual is sexual, or even referred to as allosexual.
You can consider graysexuality as the midpoint among asexuality and homosexuality. Graysexual individuals infrequently experience sexual fascination, or they experience it with low force. A few people contend that demisexuality doesn’t fit under the asexual umbrella since it just alludes to the conditions under which you feel sexual fascination. It does not remark on how regularly or how seriously you experience sexual attraction. Someone who will, in general, feel serious sexual attraction toward almost all of their dearest companions and accomplices might think that they are demisexual.
Somebody who feels like having a sexual relationship with a couple of dear companions or accomplices, yet not regularly and not seriously, might recognise firmly with graysexuality or asexuality. Then again, individuals contend that demisexuality falls under the asexual group. This argument is on the grounds that demisexuality depicts a circumstance where you just experience sexual fascination in particular conditions.
Can a demisexual person change their sexuality over time?
A person’s sexual orientation is fluid and can change over time and with different circumstances. At the same time, you can be demisexual and graysexual or demisexual and asexual. Remember that it is reasonable to change between these sexualities. During various stages of life, you may discover your ability for sexual fascination shifts after some time. For instance, you may go from being allosexual to being graysexual to being asexual.
According to the Asexual Census conducted in 2015, more than 80 per cent of the subjects recognised themselves as heterosexual, homosexual or other sexualities before realising that they were asexual. This rate is a perfect example of how fluctuating sexuality can be.
Identifying the sexuality
Since sexuality is a fluid experience, being a demisexual person can be different for each person. Read on to know some of the signs that you can use to identify a demisexual person.
- Rarely do demisexual individuals feel sexual excitement towards people like colleagues, strangers and other individuals that they find in daily life.
- They might be sexually aroused by someone that they have a deep connection with such as a close friend or a romantic partner.
- Their enthusiastic association with somebody has a significant influence on whether they are sexually aroused by the.
- They are not excited by the notion of immersing in sexual associations with somebody that they do not know well. Even if they are aesthetically pleasing, demisexual people might not find them attractive.
- Before starting a romantic relationship with someone, they prefer to build a strong friendship first.
- While thinking about sexual activities, they are not eager right away.
- They are not comfortable or do not like the idea of one-night stands (1).
- The love language of a demisexual person is generally physical touch. They appreciate cuddles, hugs and kisses.
- Relationships are not usually casual for demisexual people.
- Since they do not feel attraction to a gorgeous person that they meet in the street, it is evident that looks are not what matters to them. They care more about an individual’s character and appearance.
- Their opinions about relationships can be naturally different from that of their friend’s group.
- Most demisexual people do not enjoy flirting. Since it is not simple for them to create a sexual connection as soon as they meet someone, they are never in the mood for flirting.
It is important to remember that these signs do not assure that a person is demisexual. You can have all these traits and be heterosexual, homosexual or of any other sexuality. At the same time, you can be demisexual and not agree with many of the above.
Nidhia Sebastian is an English literature graduate who looks forward to a career that complements her passion. Her never-ending love for language has brought her to creative writing. Having an open heart to knowledge is what leaves her with a thirst to explore the world. She believes in living life to the fullest and hopes to convey the same enthusiasm through her words.
Trypophobia: Symptoms, Diagnosis & Treatment
Trypophobia is the fear of carefully packed holes, and people having it cannot tolerate the atmosphere around holes. One can feel anxious and irritated around the pack of holes. For instance, one can even feel worried after seeing the body of strawberry, which ultimately signifies having Trypophobia and eventually feeling anxious or discomfort. Trypophobia today is limited, and the research still hasn’t clarified whether it is an official condition among people.
What Triggers Trypophobia?
Anything around our atmosphere having tightly packed holes, whether be it on animals, objects, or even the buildings having holes, can eventually trigger Trypophobia. Some of the familiar objects and materials that trigger Typophobia are mentioned below.
- Lotus seed pods
- Cluster of eyes
Symptoms of Trypophobia
Every person having Trypophobia may react differently depending upon how they perceive the object in front of them. Some of the common symptoms are mentioned below that one may experience after seeing the objects with tightly packed holes around it.
- Discomfort around that object
- Panic attack
Until today, not much risk has been established with Trypophobia. According to a study, there is somewhat a link between Trypophobia, major depression, and generalized anxiety disorder (GAD). People having Trypophobia may somehow have connections with the GAD and thus face this type of phobia. Back in 2016, a study was established between the relationships of social anxiety and Tyrpophobia.
For the diagnosis of Trypophobia, doctors may ask different questions related to the symptoms to confirm if one has this phobia or not. The questions might also include your experience regarding medical, psychiatric, and social history. Trypophobia is not yet officially recognized as a phobia and is not considered diagnosable by most medical institutions(1).
Treatment for Trypophobia
Different Phobias are treated through various methods. Most phobias are treated through exposure therapy, which is considered to be the most effective for the treatment of phobias. Exposure therapy focuses on changing one’s perspective towards the situation or the object, causing fear towards the patient and eventually making it go away. Besides exposure therapy, cognitive-behavioral therapy (CBT) is used, which helps manage anxiety and ultimately drives it off. Some of the other methods which can be used to cure Trypophobia are mentioned below.
- General talk therapy
- Medicines like beta-blockers which reduce anxiety and panic inside people.
- Natural methods like deep-breathing and yoga
- Physical activities which manage anxiety
- Mindful strategies which control the emotions inside people.
Anyone who is facing any phobia, can try to have mindfulness things and have enough rest along with a balanced diet, avoid caffeine and similar substances which trigger anxiety and be determined to face fearful situations and encounter them with determination. These points can all influence to drive off phobias to a great extent and make it go away.
Trypophobia has yet no been an official phobia and cannot impact a person’s everyday living. Although, very few people have the symptoms for this and may only trigger very little anxiety in the body of people experiencing it. People can be in touch with doctors or psychiatrists to solve their phobias and live a healthy life ahead.
I am a creative writer who likes to spread information. With different hobbies like panting and singing, i like writing and expressing the most. I am currently working as a content writer and am always curious to learn something new.
Surya Namaskar Benefits: How to do surya Namaskar step by step guide
Every one of us must do a little bit of yoga on a daily basis. And guess which is the best yoga practice? Undoubtedly, Surya Namaskar!
Many of us know it by the term ‘Surya Namskar,’ Several others know it by the word ‘Sun Salutation.’
Though this is the era of Fitbit and Fitness trackers but the old yoga practice of Surya namaskar will never go out of fashion. Not only is it beneficial for health, but it also impacts our minds.
So, today you will know every little detail about Surya namaskar or sun salutation. We will be talking about its meaning, Surya Namaskar benefits, how to do it, and much more.
So keep reading!
Sun Salutation- Meaning and Health Benefits of Surya Namaskar!
We all have must (at least once in our life) heard the name ‘Surya namaskar.’
And in case you have not heard of it, then I have only one question for you!
Are you guys even real?
Surya namaskar is a 12 step yoga asan that we used to do in our Physical education classes in schools. Our teachers always lectured us about the health benefits of Surya Namaskar, but you what, they were absolutely right.
If you dive deep into the Surya namaskar benefits, you wiill be shocked to the core.
This simple yoga asan has tons of health benefits for us.
Let’s start from the meaning and then go to the Surya namaskar benefits.
Surya Namaskar or Sun Salutation!
Surya Namaskar, or as we know it in English, Sun salutation is a 12 step yoga asan that helps us in achieving a sound mind and body.
Surya namaskar is an ancient ritual that includes prostrating towards the rising sun.
In ancient times, it was a belief that nothing (no asan) is complete without worshipping the Sun god.
And that is how Surya namaskar gained its importance.
The asan might look simple, but deep down, it has thousands of benefits for us.
Surya Namaskar Benefits!
Surya Namaskar is right for your body and the proper growth and development of your mind. It has tons of hidden benefits for us. Some of the Surya Namaskar benefits (benefits of Surya namaskar) are as follows:
- It helps in reducing tension.
- Surya Namaskar improves overall body circulation.
- It regulates your breathing.
- Your entire body is stretched in Surya Namaskar, and thus it helps you to stretch, flex, and tone your muscles.
- It helps in maintaining excellent cardiovascular health.
- Surya Namaskar helps in stimulating our nervous system.
- It is an outstanding yoga asan for weight loss.
- Surya Namaskar strengthens our immune system.
- It gives an overall healthy and sound mind and body.
How to do Surya Namaskar? – A Step by Step Guide!
Surya namaskar has 12 steps. According to the health experts, doing one full round of Surya Namaskar burns 13.90 calories.
Thus, you can make a rough estimate of how much beneficial is this asan for us. But it will only benefit you if you do it properly.
Thus, let us know more about the 12 positions of Surya namaskar!
1) Pranamasana ( The Prayer Pose)
- Stand straight with your feet together.
- Expand your shoulder area and relax your chest area.
- While breathing in, slowly lift both of your arms from the sides, and while exhaling, bring back your palms together.
- Stand in the prayer position.
2) Hastauttanasana (The Raised arms pose)
- While breathing in lift your hands up.
- Keep your biceps closer to the ears and stretch backward.
- Stretch your whole body from toes to the fingers of your hands.
NOTE: Too strong this position. You can even try to push your butt area forward.
3) Hastapadasana (The Standing forward bend)
- While breathing out, come back forward from the raised arm pose.
- Do not forget to keep your spine erect.
- Exhale completely, and bring your hands down.
- Touch your hands to the floor or your feet.
NOTE: To make this position more intense, you can bend your knees, try touching your palms to the floor and try to straighten your knees. Make sure to keep your hands in a fixed position and not move then here and there.
4) Ashwa Sanchalanasana (The Equestrian pose)
- While breathing in, take your right leg back (as far as possible).
- Then, bring your right knee to the floor and lock up this position.
NOTE: To make this pose intense, make sure that your left foot is between your palms.
5) Dandasana (The Stick pose)
- While breathing in, take your left foot backward.
- Stay still and keep your entire body in a straight line.
NOTE: Too intense this pose, place your arms perpendicular to the floor.
6) Ashtanga Namaskara (The Salute with eight parts or points)
- Slowly bring your knees down to the yoga mat/floor while breathing out.
- Take your hips swiftly away from the ground.
- Slide forward and gently rest your chest and chin on the floor.
- Raise our whole posture a little bit.
7) Bhujangasana (The Cobra Pose)
- Gently slide forward and raise your chest into the cobra pose.
- Keep your elbows bent and your shoulders away from the ears.
- Loom up towards the ceiling.
NOTE: To make this pose intense, gently push the chest forward while breathing in and naval downwards while breathing out.
Make sure to stretch your body as soon as possible.
8) Adho Mukha Svanasana (The Downward facing dog pose)
- While breathing in, lift your hips in the air.
- Make an inverted ‘V’ position with your body.
NOTE: To make this pose intense, try keeping your heels the ground and go for a deeper stretch.
9) Ashwa Sanchalanasana (The Equestrian pose)
- While breathing in get your right foot forward and place it between your palms.
- Bend down your left knee and lock the position.
- Stretch the body as much as possible.
NOTE: Place your right foot precisely between your palms to get the maximum stretch. Pull your hips down and stretch the body.
10) Hastapadasana (The Standing forward bend)
- While breathing out, bring the left foot forward and place your feet together.
- Place the palms on the ground. You can either bend the knees or keep them straight (according to your comfort).
11) Hastauttanasana (The Raised arms pose)
- While breathing in, pull your spine up.
- Raise your hands and bend them backward.
- Push your hips outward.
- Stretch as much as possible.
12) Tadasana (The Mountain Pose)
- While breathing out, slowly straighten your body.
- Bring your arms down and relax.
With this last step, we finish one full cycle of the Surya Namaskar.
Most Frequently Asked Questions about Surya Namaskar Benefits!
1) How many times should we do Surya namaskar in a day?
To get all the benefits of Surya namaskar, you must do it 12 times a day.
In case you are a beginner, you can initially do 4-5 rounds and gradually increase the number of rounds.
2) Is it food to do Surya namaskar daily for Surya namaskar benefits?
There is no harm in doing Surya Namaskar daily. If you inculcate the habit of regularly doing it, you will, without a doubt, get all the benefits of Surya namaskar and even notice the changes in your body after some time.
3) Can Surya namaskar reduce belly fat?
One of the essential benefits of Surya namaskar is that it reduces overall body fat. Thus, doing Surya namaskar regularly will reduce your fat because every round of Surya Namaskar burns 13.90 calories.
4) Can you perform Surya Namaskar in periods?
There is no harm in performing Surya namaskar in periods (1). But you must do fast, especially during heavy bleeding.
5) Can Surya namaskar reduce breast size?
Yes, Surya namaskar can reduce the flab around your chest and firm your breasts. But it will only happen if you perform it correctly. To reduce breasts, you must do Surya namaskar 10-15 times a day.
Alongside her graduation, she is pursuing her passion for content writing. She is young, raw, and continuously thriving for the best. Her hobbies include debates and travelling. Despite these nerdy things, she also likes to netflix and chill.
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