St. Jude Children’s Research Hospital COVID-19 screening and vaccination program for employees offers early evidence that vaccine protects against asymptomatic infection, which has fueled the pandemic
Credit: St. Jude Children’s Research Hospital
Vaccination dramatically reduced COVID-19 symptomatic and asymptomatic infections in St. Jude Children’s Research Hospital employees compared with their unvaccinated peers, according to a research letter that appears today in the Journal of the American Medical Association.
The study is among the first to show an association between COVID-19 vaccination and fewer asymptomatic infections. When the Pfizer-BioNTech BNT162b2 vaccine was authorized for use in the U.S., the vaccine was reported to be highly effective at preventing laboratory-confirmed COVID-19. Clinical trial data suggested that the two-dose regimen reduced symptomatic disease, including hospitalization and death. But an association with reduced asymptomatic infection was unclear.
“While further research is needed, by preventing infections, including in people who have no symptoms, there is a high possibility that vaccination will decrease transmission of SARS-CoV-2,” said Diego Hijano, M.D., of the St. Jude Department of Infectious Diseases. He and Li Tang, Ph.D., of St. Jude Biostatistics, are the first authors of the report. Tang is also the corresponding author.
The study involved 5,217 St. Jude employees who were eligible under Tennessee state guidelines for vaccination between Dec. 17, 2020, and March 20, 2021. More than 58% of employees were vaccinated during that period. Most workers received both doses.
Overall, vaccination reduced the risk of asymptomatic and symptomatic SARS-CoV-2 infection by 79% in vaccinated employees compared with their unvaccinated colleagues. An analysis of asymptomatic infections alone found vaccination reduced the risk by 72%.
Protection was even greater for employees who completed two doses. A week or more after receiving the second dose, vaccinated employees were 96% less likely than unvaccinated workers to become infected with SARS-CoV-2. When researchers looked just at asymptomatic infections, vaccination reduced the risk by 90%.
Finding SARS-CoV-2 infections
The research stems from a program that St. Jude leaders began in March 2020 to protect patients and employees from the pandemic virus.
The effort included targeted testing for employees with COVID-19 symptoms or known exposure to the pandemic virus. The plan also involved routine, laboratory testing of asymptomatic employees. Nasal swabs were collected at least weekly from self-reported asymptomatic on-campus workers to perform polymerase chain reaction to detect asymptomatic SARS-CoV-2 infection.
“This study was possible because St. Jude invested in resources to determine how best to control the disease and protect our patients and employees,” Tang said. “Few places then or now provide such broad asymptomatic testing.”
Hijano said, “Testing has been invaluable to the institutional COVID-19 mitigation plan. In the end, the testing also serves as a unique tool that helps to fill in critical knowledge gaps.”
Results by the numbers
During the study, 236 of the 5,217 employees included in the analysis tested positive for SARS-CoV-2. They included 185 unvaccinated employees and 51 of the 3,052 workers who had received at least one dose of the vaccine.
Almost half of the positive cases, 108, reported no symptoms upon testing. The asymptomatic cases included 20 employees who had received one vaccine dose and three who tested positive within seven days of the second dose. “The results are a reminder of the many hidden cases in the population, which makes containing the virus a big challenge,” Tang said.
The study group included a cross-section of employees in regard to race and gender. More than 80% of employees were younger than 65 years old. The vaccinated group included a higher percentage of health care staff, 47%, than the unvaccinated employees, 25.7%.
Authors and funding
The senior authors are James Hoffman, Pharm.D., and Randall Hayden, M.D., of St. Jude. The other authors are Aditya Gaur, Terrence Geiger and Ellis Neufeld, all of St. Jude.
The research was funded in part by ALSAC, the St. Jude fundraising and awareness organization.
St. Jude Children’s Research Hospital
St. Jude Children’s Research Hospital is leading the way the world understands, treats and cures childhood cancer and other life-threatening diseases. It is the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. Treatments developed at St. Jude have helped push the overall childhood cancer survival rate from 20% to 80% since the hospital opened more than 50 years ago. St. Jude freely shares the breakthroughs it makes, and every child saved at St. Jude means doctors and scientists worldwide can use that knowledge to save thousands more children. Families never receive a bill from St. Jude for treatment, travel, housing and food — because all a family should worry about is helping their child live. To learn more, visit stjude.org or follow St. Jude on social media at @stjuderesearch.
Frangopol awarded ISHMII Mufti Medal for civil structural health monitoring achievements
Lehigh University professor will be recognized for lifetime achievements during 10th International Conference on Structural Health Monitoring of Intelligent Infrastructure (SHMII10)
The International Association of Structural Health Monitoring of Intelligent Infrastructure (ISHMII) has honored Dan M. Frangopol, the inaugural Fazlur R. Khan Endowed Chair of Structural Engineering and Architecture at Lehigh University, with the 2021 Aftab Mufti Medal for lifetime achievement in civil structural health monitoring. The medal will be presented at the ISHMII award ceremony during the 10th International Conference on Structural Health Monitoring of Intelligent Infrastructure (SHMII10), June 30-July 2, 2021, in Porto, Portugal.
Frangopol has made seminal scholarly contributions to structural health monitoring (SHM) by bringing reliability and optimization methods into this field. He is internationally recognized for pioneering the integration of health monitoring in life-cycle performance assessment, prediction, and optimization of structural systems under uncertainty. His innovative methodologies have been instrumental to tremendous advances in health monitoring of structural systems.
His contributions to the field of SHM include: (a) formulating an approach for the inclusion of monitoring data in the structural reliability assessment process; (b) demonstrating the use of monitoring data for the development of structural reliability prediction models; (c) optimizing the planning of structural performance monitoring based on reliability importance assessment; (d) optimizing maintenance strategies based on multiple limit states and monitoring; (d) integrating SHM in life-cycle performance assessment of civil infrastructure systems under uncertainty; (e) proposing cost-effective lifetime SHM based on availability; and (f) optimizing scheduling of inspection and monitoring for fatigue-sensitive structures.
These contributions are fully documented in (a) a recent book: Life-Cycle of Structures under Uncertainty: Emphasis on fatigue-sensitive civil and marine structures, which Frangopol published in 2019 (CRC Press, Science Publishers) with his former student S. Kim as co-author, (b) several book chapters, and (c) about 40 papers in archival journals.
Frangopol is the Founding President of both the International Association for Bridge Maintenance and Safety (IABMAS) and the International Association for Life-Cycle Civil Engineering (IALCCE) as well as founding vice-president of ISHMII. He is also the past vice-president of the International Association for Structural Safety and Reliability (IASSAR) and past vice-president of the Engineering Mechanics Institute (EMI) of ASCE, as well as past member of its Board of Governors.
He has authored/co-authored three books, more than 50 book chapters, and over 420 articles in archival journals (117 in ASCE journals), including 11 prize-winning papers.
Frangopol is the founder and editor-in-chief of Structure and Infrastructure Engineering, an international peer-reviewed journal launched in 2005, and of the book series Structures and Infrastructures.
He is the recipient of several medals, awards, and prizes from ASCE, IABSE, IASSAR, ISHMII, and other professional organizations, including the Newmark, Freudenthal, Housner, Lin, Khan, and Croes (twice) medals; the Ang, Howard, Moisseiff, and State-of-the Art of Civil Engineering (three times) awards; the Munro, Noble, Reese, and Wellington prizes; the Lifetime Achievement Award in Education (OPAL); and the Civil Engineer of the Year Award.
Frangopol holds four honorary doctorates, 14 honorary professorships, and six guest professorships from major universities.
He is an Elected Member of the US National Academy of Construction, a Foreign Member of the Academy of Europe (London), a Foreign Associate of the Engineering Academy of Japan, a Foreign Member of the Royal Academy of Belgium, an Honorary Member of the Romanian Academy, an Honorary Member of the Romanian Academy of Technical Sciences, and a Distinguished Member of ASCE.
Read more about Frangopol’s research and achievements here.
Website: Dan M. Frangopol
International Association of Structural Health Monitoring of Intelligent Infrastructure
Metal catalysts used for environmental sustainability found to degrade and become less effective
New research is showing that some tiny catalysts being considered for industrial-scaled environmental remediation efforts may be unstable during operation.
Chemists from the University of Waterloo studied the structures of complex catalysts known as “nanoscale electrocatalysts” and found that they are not as stable as scientists once thought. When electricity flows through them during use, the atoms may rearrange. In some cases, the researchers found, electrocatalysts degrade completely.
Understanding why and how this rearrangement and degradation happens is the first step to using these nanoscale electrocatalysts in environmental remediation efforts such as removing atmospheric carbon dioxide and groundwater contaminants and transforming them into higher-value products such as fuels.
“Current electrocatalysts rely on complex nanoscale structures in order to optimize their efficiency,” said Anna Klinkova, a professor in Waterloo’s Department of Chemistry. “What we found, however, is that the superior performance of these complex nanomaterials often come at a cost of their gradual structural degradation, as there is a trade-off between their effectiveness and stability.”
Klinkova and her team discovered that the rearrangement of atoms in the catalyst depended on the type of metal, structural shape, and the reaction conditions of the catalyst.
They identified two reasons for the rearrangements. Some small molecules can temporarily attach to the surface of the catalyst and reduce the energy needed for an atom to move across the surface. In other cases, narrow areas within the catalyst concentrate the electron’s current, causing the metal atoms to displace via a process called electromigration.
Electromigration has been previously identified in microelectronics, but this is the first time it has been connected to nanoscale catalysts.
These findings establish a framework for assessing structural stability and mapping the changing geometry of nanoscale catalysts, which is an important step to designing better catalysts in the future.
“These structural effects could be used as one of the design rules in future catalyst development to maximize their stability,” Klinkova said. “You could also purposefully induce reconstruction to a different structure that becomes active as the reaction starts.”
The study, Interplay of electrochemical and electrical effects induces structural transformations in electrocatalysts, was recently published in the journal Nature Catalysis.
The MedWalk diet: A step closer to walking away from dementia
It’s been named the world’s best diet for weight loss, but now researchers at the University of South Australia are confident that the Mediterranean Diet – combined with a daily bout of exercise – can also stave off dementia, slowing the decline in brain function that is commonly associated with older age.
In the world-first study starting this week, researchers at the University of South Australia and Swinburne University, along with a consortium of partners* will explore the health benefits of older people adhering to a Mediterranean diet, while also undertaking daily walking.
Termed the MedWalk Trial, the two-year, $1.8 million NHMRC-funded study will recruit 364 older Australians – aged 60-90 years, living independently in a residential village, and without cognitive impairment – across 28 residential sites in South Australia and Victoria.
It’s a timely study, particularly given Australia’s ageing population, where around a quarter of all Australians will be aged 65+ by 2050.
Lead UniSA researcher, Associate Professor Karen Murphy, says combining the dietary benefits of the Mediterranean Diet with the health benefits of an exercise intervention could deliver significant benefits.
“Dementia is a condition that affects a person’s thinking, behaviour and ability to perform everyday tasks. While it is more common in older Australians, it’s not a normal part of ageing,” Assoc Prof Murphy says.
“In Australia, around 472,000 people are living with dementia. Each year it costs the economy more than $14 billion which is expected to balloon to more than $1 trillion over the next 40 years.
“While there is currently no prevention or cure for dementia, there is growing consensus that a focus on risk reduction can have positive outcomes. That’s where our study comes in.
“Early pilots of our MedWalk intervention show improved memory and thinking in a sub-group of older participants adhering to a combination of Mediterranean diet and daily walking for six months.
“We’re now extending this study across a broader group of older Australians, using carefully-designed behavioural change and maintenance strategies in the hope of substantially reducing the incidence of dementia across Australia.”
A Mediterranean diet is high in fruit, vegetables, legumes, whole grains, and fish, while being low in saturated fats, red meat, and alcohol.
The 24-month study will randomly assign residential community sites the MedWalk intervention, or their usual lifestyle (the control group), so that all participants who live at one facility will be in the same group. Changes to diet and walking will be supported through organised and regular motivational, dietary and exercise sessions.
Head of Neurocognitive Ageing Research at Swinburne’s Centre for Human Psychopharmacology and Chief Investigator, Professor Andrew Pipingas, says this trial is about trying to prevent the onset of dementia.
“As it’s extremely difficult to find a cure and treat those in the later stages of the disease, focusing our efforts on helping those at risk of developing dementia to stay healthy is one-way to ensure Australians stay well in future.”
Notes for editors:
- May is National Mediterranean Diet Month
- The full list of partners involved in this study are: Swinburne University; University of South Australia; Deakin University; La Trobe University; RMIT University; Murdoch University; Sheffield Hallam University, UK; University of East Anglia, UK; University College Cork, Ireland.
Media contact: Annabel Mansfield T: +61 8 8302 0351 M: +61 417 717 504
E: [email protected]
Researchers: UniSA: Associate Professor Karen Murphy T: +61 8 8302 1033
E: [email protected]
Swinburne: Professor Andrew Pipingas T: +61 3 9214 5215 E: [email protected]
Researchers trace dust grain’s journey through newborn solar system
Combining atomic-scale sample analysis and models simulating likely conditions in the nascent solar system, the study revealed clues about the origin of crystals that formed more than 4.5 billion years ago
A research team led by the University of Arizona has reconstructed in unprecedented detail the history of a dust grain that formed during the birth of the solar system more than 4.5 billion years ago. The findings provide insights into the fundamental processes underlying the formation of planetary systems, many of which are still shrouded in mystery.
For the study, the team developed a new type of framework, which combines quantum mechanics and thermodynamics, to simulate the conditions to which the grain was exposed during its formation, when the solar system was a swirling disk of gas and dust known as a protoplanetary disk or solar nebula. Comparing the predictions from the model to an extremely detailed analysis of the sample’s chemical makeup and crystal structure, along with a model of how matter was transported in the solar nebula, revealed clues about the grain’s journey and the environmental conditions that shaped it along the way.
The grain analyzed in the study is one of several inclusions, known as calcium-aluminum rich inclusions, or CAIs, discovered in a sample from the Allende meteorite, which fell over the Mexican state of Chihuahua in 1969. CAIs are of special interest because they are thought to be among the first solids that formed in the solar system more than 4.5 billion years ago.
Similar to how stamps in a passport tell a story about a traveler’s journey and stops along the way, the samples’ micro- and atomic-scale structures unlock a record of their formation histories, which were controlled by the collective environments to which they were exposed.
“As far as we know, our paper is the first to tell an origin story that offers clues about the likely processes that happened at the scale of astronomical distances with what we see in our sample at the scale of atomic distances,” said Tom Zega, a professor in the University of Arizona’s Lunar and Planetary Laboratory and the first author of the paper, published in The Planetary Science Journal.
Zega and his team analyzed the composition of the inclusions embedded in the meteorite using cutting-edge atomic-resolution scanning transmission electron microscopes – one at UArizona’s Kuiper Materials Imaging and Characterization Facility, and its sister microscope located at the Hitachi factory in Hitachinaka, Japan.
The inclusions were found to consist mainly of types of minerals known as spinel and perovskite, which also occur in rocks on Earth and are being studied as candidate materials for applications such as microelectronics and photovoltaics.
Similar kinds of solids occur in other types of meteorites known as carbonaceous chondrites, which are particularly interesting to planetary scientists as they are known to be leftovers from the formation of the solar system and contain organic molecules, including those that may have provided the raw materials for life.
Precisely analyzing the spatial arrangement of atoms allowed the team to study the makeup of the underlying crystal structures in great detail. To the team’s surprise, some of the results were at odds with current theories on the physical processes thought to be active inside protoplanetary disks, prompting them to dig deeper.
“Our challenge is that we don’t know what chemical pathways led to the origins of these inclusions,” Zega said. “Nature is our lab beaker, and that experiment took place billions of years before we existed, in a completely alien environment.”
Zega said the team set out to “reverse-engineer” the makeup of the extraterrestrial samples by designing new models that simulated complex chemical processes, which the samples would be subjected to inside a protoplanetary disk.
“Such models require an intimate convergence of expertise spanning the fields of planetary science, materials science, mineral science and microscopy, which was what we set out to do,” added Krishna Muralidharan, a study co-author and an associate professor in the UArizona’s Department of Materials Science and Engineering.
Based on the data the authors were able to tease from their samples, they concluded that the particle formed in a region of the protoplanetary disk not far from where Earth is now, then made a journey closer to the sun, where it was progressively hotter, only to later reverse course and wash up in cooler parts farther from the young sun. Eventually, it was incorporated into an asteroid, which later broke apart into pieces. Some of those pieces were captured by Earth’s gravity and fell as meteorites.
The samples for this study were taken from the inside of a meteorite and are considered primitive – in other words, unaffected by environmental influences. Such primitive material is believed to not have undergone any significant changes since it first formed more than 4.5 billion years ago, which is rare. Whether similar objects occur in asteroid Bennu, samples of which will be returned to Earth by the UArizona-led OSIRIS-REx mission in 2023, remains to be seen. Until then, scientists rely on samples that fall to Earth via meteorites.
“This material is our only record of what happened 4.567 billion years ago in the solar nebula,” said Venkat Manga, a co-author of the paper and an assistant research professor in the UArizona Department of Materials Science and Engineering. “Being able to look at the microstructure of our sample at different scales, down to the length of individual atoms, is like opening a book.”
The authors said that studies like this one could bring planetary scientists a step closer to “a grand model of planet formation” – a detailed understanding of the material moving around the disk, what it is composed of, and how it gives rise to the sun and the planets.
Powerful radio telescopes like the Atacama Large Millimeter/submillimeter Array, or ALMA, in Chile now allow astronomers to see stellar systems as they evolve, Zega said.
“Perhaps at some point we can peer into evolving disks, and then we can really compare our data between disciplines and begin answering some of those really big questions,” Zega said. “Are these dust particles forming where we think they did in our own solar system? Are they common to all stellar systems? Should we expect the pattern we see in our solar system – rocky planets close to the central star and gas giants farther out – in all systems?
“It’s a really interesting time to be a scientist when these fields are evolving so rapidly,” he added. “And it’s awesome to be at an institution where researchers can form transdisciplinary collaborations among leading astronomy, planetary and materials science departments at the same university.”
The study was co-authored by Fred Ciesla at the University of Chicago and Keitaro Watanabe and Hiromi Inada, both with the Nano-Technology Solution Business Group at Hitachi High-Technologies Corp. in Japan.
Funding was provided through NASA’s Emerging Worlds Program; NASA’s Origins Program; and NASA’s Nexus for Exoplanet System Science (NExSS) research coordination network, which is sponsored by NASA’s Science Mission Directorate. NASA and the National Science Foundation provided the funding for the instrumentation in LPL’s Kuiper Materials Imaging and Characterization Facility.
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