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Arrowhead Announces Improvement in Fibrosis after ARO-AAT Treatment in Patients with Alpha-1 Liver Disease

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Home > Press > Arrowhead Announces Improvement in Fibrosis after ARO-AAT Treatment in Patients with Alpha-1 Liver Disease

Abstract:
Arrowhead Pharmaceuticals Inc. (NASDAQ: ARWR) today announced positive interim 48-week liver biopsy results from the AROAAT2002 study, an open-label Phase 2 clinical study of ARO-AAT, the company’s second generation investigational RNA interference (RNAi) therapeutic being co-developed with Takeda Pharmaceutical Company Limited (“Takeda”) as a treatment for the rare genetic liver disease associated with alpha-1 antitrypsin deficiency (AATD). The results demonstrate that ARO-AAT treatment led to a consistent and substantial reduction in intra-hepatic mutant AAT protein (Z-AAT), both Z-AAT monomer and Z-AAT polymer; a consistent decrease in histological globule burden; improvements in fibrosis; and, improvements in other relevant biomarkers of liver health. Arrowhead intends to present additional interim AROAAT2002 data at an upcoming medical congress, pending abstract acceptance.

Arrowhead Announces Improvement in Fibrosis after ARO-AAT Treatment in Patients with Alpha-1 Liver Disease


Pasadena. CA | Posted on April 28th, 2021

After 48 weeks of treatment with investigational ARO-AAT in cohort 2 (n=5) of the AROAAT2002 study, the following results were observed:

Four of the five patients achieved a 1 or greater stage improvement in Metavir fibrosis stage, with no worsening of fibrosis in the fifth patient
All five patients demonstrated reductions in histological globule assessment scores
Total intra-hepatic Z-AAT decreased by 77-97%
After only 24 weeks of treatment with investigational ARO-AAT in cohort 1 (n=4) of the AROAAT2002 study, the following results were observed:

Two of the four patients achieved a 1 or greater stage improvement in Metavir fibrosis stage, with no worsening of fibrosis in the other two patients
The two patients who improved fibrosis stages during treatment were both deemed cirrhotic (F4) when the study began
All four patients demonstrated reductions in histological globule assessment scores
As previously reported, total intra-hepatic Z-AAT decreased by 72-95%
Javier San Martin, M.D., chief medical officer at Arrowhead, said: “The results from treatment with investigational ARO-AAT in the Phase 2 AROAAT2002 open-label study continue to impress us. We believe the pharmacodynamic effect in alpha-1 patients is clear and consistent. The results from 24 and 48 weeks of treatment also indicate that when production of the Z-AAT protein is inhibited, the liver has the ability to clear the accumulated mutant protein and begin the fibrosis regression process earlier and more efficiently than we anticipated, even in patients with severe liver disease. We look forward to sharing more details about these exciting results at an upcoming medical congress. We also intend to use these and other results to inform further interactions with regulatory authorities to pursue opportunities for potential accelerated approval pathways, if appropriate. Our collaboration with Takeda on the ARO-AAT program has been highly productive, and we continue to see them as the ideal partner as the program advances towards patients in need of new therapies for alpha-1 liver disease.”

In October 2020, Arrowhead and Takeda announced a collaboration and licensing agreement to develop ARO-AAT. Under the terms of the agreement, Arrowhead and Takeda will co-develop ARO-AAT which, if approved, will be co-commercialized in the United States under a 50/50 profit-sharing structure. Outside the U.S., Takeda will lead the global commercialization strategy and receive an exclusive license to commercialize ARO-AAT with Arrowhead eligible to receive tiered royalties of 20-25% on net sales. Arrowhead received an upfront payment of $300 million and is eligible to receive potential development, regulatory and commercial milestones of up to $740 million.

AROAAT2002 (NCT03946449) is a pilot open-label, multi-dose, Phase 2 study to assess the response to ARO-AAT in 16 patients with AATD associated liver disease and baseline liver fibrosis. All eligible participants receive a pre-dose biopsy and an end of study biopsy. Treated participants will also be offered the opportunity to continue treatment in an open-label extension (OLE). Including the OLE, interim assessments will be made after 6 months, 12 months, 18 months, and 24 months of treatment with ARO-AAT.

####

About Arrowhead Pharmaceuticals, Inc.
About Arrowhead Pharmaceuticals

Arrowhead Pharmaceuticals develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

For more information, please visit www.arrowheadpharma.com, or follow us on Twitter @ArrowheadPharma. To be added to the Company’s email list and receive news directly, please visit http://ir.arrowheadpharma.com/email-alerts .

Safe Harbor Statement under the Private Securities Litigation Reform Act:

This news release contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. Any statements contained in this release except for historical information may be deemed to be forward-looking statements. Without limiting the generality of the foregoing, words such as “may,” “will,” “expect,” “believe,” “anticipate,” “intend,” “plan,” “project,” “could,” “estimate,” or “continue” are intended to identify such forward-looking statements. In addition, any statements that refer to projections of our future financial performance, trends in our businesses, or other characterizations of future events or circumstances are forward-looking statements. These statements are based upon our current expectations and speak only as of the date hereof. Our actual results may differ materially and adversely from those expressed in any forward-looking statements as a result of numerous factors and uncertainties, including the continuing impact of the COVID-19 pandemic, the safety and efficacy of our product candidates, the duration and impact of regulatory delays in our clinical programs, our ability to finance our operations, the likelihood and timing of the receipt of future milestone and licensing fees, the future success of our scientific studies, our ability to successfully develop and commercialize drug candidates, the timing for starting and completing clinical trials, rapid technological change in our markets, the enforcement of our intellectual property rights, and the other risks and uncertainties described in our most recent Annual Report on Form 10-K, subsequent Quarterly Reports on Form 10-Q and other documents filed with the Securities and Exchange Commission from time to time. We assume no obligation to update or revise forward-looking statements to reflect new events or circumstances.

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Contacts:
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Vince Anzalone, CFA
626-304-3400

Investors:
LifeSci Advisors, LLC
Brian Ritchie
212-915-2578
www.lifesciadvisors.com

Media:
LifeSci Communications, LLC
Josephine Belluardo, Ph.D.
646-751-4361
www.lifescicommunications.com

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A silver lining for extreme electronics

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Home > Press > A silver lining for extreme electronics

MSU researchers developed a process to create more resilient circuitry, which they demonstrated by creating a silver Spartan helmet. The circuit was designed by Jane Manfredi, an assistant professor in the College of Veterinary Medicine. Credit: Acta Materialia Inc./Elsevier
MSU researchers developed a process to create more resilient circuitry, which they demonstrated by creating a silver Spartan helmet. The circuit was designed by Jane Manfredi, an assistant professor in the College of Veterinary Medicine. Credit: Acta Materialia Inc./Elsevier

Abstract:
Tomorrow’s cutting-edge technology will need electronics that can tolerate extreme conditions. That’s why a group of researchers led by Michigan State University’s Jason Nicholas is building stronger circuits today.

A silver lining for extreme electronics


East Lansing, MI | Posted on April 30th, 2021

Nicholas and his team have developed more heat resilient silver circuitry with an assist from nickel. The team described the work, which was funded by the U.S. Department of Energy Solid Oxide Fuel Cell Program, on April 15 in the journal Scripta Materialia.

The types of devices that the MSU team is working to benefit — next-generation fuel cells, high-temperature semiconductors and solid oxide electrolysis cells — could have applications in the auto, energy and aerospace industries.

Although you can’t buy these devices off the shelf now, researchers are currently building them in labs to test in the real world, and even on other planets.

For example, NASA developed a solid oxide electrolysis cell that enabled the Mars 2020 Perseverance Rover to make oxygen from gas in the Martian atmosphere on April 22. NASA hopes this prototype will one day lead to equipment that allows astronauts to create rocket fuel and breathable air while on Mars.

To help such prototypes become commercial products, though, they’ll need to maintain their performance at high temperatures over long periods of time, said Nicholas, an associate professor in the College of Engineering.

He was drawn to this field after years of using solid oxide fuel cells, which work like solid oxide electrolysis cells in reverse. Rather than using energy to create gases or fuel, they create energy from those chemicals.

“Solid oxide fuel cells work with gases at high temperature. We’re able to electrochemically react those gases to get electricity out and that process is a lot more efficient than exploding fuel like an internal combustion engine does,” said Nicholas, who leads a lab in the Chemical Engineering and Materials Science Department.

But even without explosions, the fuel cell needs to withstand intense working conditions.

“These devices commonly operate around 700 to 800 degrees Celsius, and they have to do it for a long time — 40,000 hours over their lifetime,” Nicholas said. For comparison, that’s approximately 1,300 to 1,400 degrees Fahrenheit, or about double the temperature of a commercial pizza oven.

“And over that lifetime, you’re thermally cycling it,” Nicholas said. “You’re cooling it down and heating it back up. It’s a very extreme environment. You can have circuit leads pop off.”

Thus, one of the hurdles facing this advanced technology is rather rudimentary: The conductive circuitry, often made from silver, needs to stick better to the underlying ceramic components.

The secret to improving the adhesion, the researchers found, was to add an intermediate layer of porous nickel between the silver and the ceramic.

By performing experiments and computer simulations of how the materials interact, the team optimized how it deposited the nickel on the ceramic. And to create the thin, porous nickel layers on the ceramic in a pattern or design of their choosing, the researchers turned to screen printing.

“It’s the same screen printing that’s used to make T-shirts,” Nicholas said. “We’re just screen-printing electronics instead of shirts. It’s a very manufacturing-friendly technique.”

Once the nickel is in place, the team puts it in contact with silver that’s melted at a temperature of about 1,000 degrees Celsius. The nickel not only withstands that heat — its melting point is 1,455 degrees Celsius — but it also distributes the liquified silver uniformly over its fine features using what’s called capillary action.

“It’s almost like a tree,” Nicholas said. “A tree gets water up to its branches via capillary action. The nickel is wicking up the molten silver via the same mechanism.”

Once the silver cools and solidifies, the nickel keeps it locked onto the ceramic, even in the 700 to 800 degree Celsius heat it would face inside a solid oxide fuel cell or a solid oxide electrolysis cell. And this approach also has the potential to help other technologies, where electronics can run hot.

“There are a wide variety of electronic applications that require circuit boards that can withstand high temperatures or high power,” said Jon Debling, a technology manager with MSU Technologies, Michigan State’s tech transfer and commercialization office. “These include existing applications in automotive, aerospace, industrial and military markets, but also newer ones such as solar cells and solid oxide fuel cells.”

As a technology manager, Debling works to commercialize Spartan innovations and he’s working to help patent this process for creating tougher electronics.

“This technology is a significant improvement — in cost and temperature stability — over existing paste and vapor deposition technologies,” he said.

For his part, Nicholas remains most interested in those cutting-edge applications on the horizon, things like solid oxide fuel cells and solid oxide electrolysis cells.

“We’re working to improve their reliability here on Earth — and on Mars,” Nicholas said.

###

Also contributing to the project were Spartan engineering researchers Assistant Professor Hui-Chia Yu, Professor Timothy Hogan and Professor Thomas Bieler. Graduate student researchers on the project included Genzhi Hu, Quan Zhou, Aiswarya Bhatlawande, Jiyun Park, Robert Termuhlen and Yuxi Ma (Zhou, Bhatlawande and Ma have since graduated).

One of the project’s coleaders at Brown University, Professor Yue Qi, also has ties to MSU. She served as faculty and the inaugural associate dean of inclusion and diversity in the College of Engineering through 2020.

####

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Contacts:
Caroline Brooks

@MSUnews

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Simple robots, smart algorithms

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When sensors, communication, memory and computation are removed from a group of simple robots, certain sets of complex tasks can still be accomplished by leveraging the robots' physical characteristics, a trait that a team of researchers led by Georgia Tech calls "task embodiment." CREDIT
Shengkai Li, Georgia Tech
When sensors, communication, memory and computation are removed from a group of simple robots, certain sets of complex tasks can still be accomplished by leveraging the robots’ physical characteristics, a trait that a team of researchers led by Georgia Tech calls “task embodiment.” CREDIT
Shengkai Li, Georgia Tech

Abstract:
Anyone with children knows that while controlling one child can be hard, controlling many at once can be nearly impossible. Getting swarms of robots to work collectively can be equally challenging, unless researchers carefully choreograph their interactions — like planes in formation — using increasingly sophisticated components and algorithms. But what can be reliably accomplished when the robots on hand are simple, inconsistent, and lack sophisticated programming for coordinated behavior?

Simple robots, smart algorithms


Atlanta, GA | Posted on April 30th, 2021

A team of researchers led by Dana Randall, ADVANCE Professor of Computing and Daniel Goldman, Dunn Family Professor of Physics, both at Georgia Institute of Technology, sought to show that even the simplest of robots can still accomplish tasks well beyond the capabilities of one, or even a few, of them. The goal of accomplishing these tasks with what the team dubbed “dumb robots” (essentially mobile granular particles) exceeded their expectations, and the researchers report being able to remove all sensors, communication, memory and computation — and instead accomplishing a set of tasks through leveraging the robots’ physical characteristics, a trait that the team terms “task embodiment.”

The team’s BOBbots, or “behaving, organizing, buzzing bots” that were named for granular physics pioneer Bob Behringer, are “about as dumb as they get,” explains Randall. “Their cylindrical chassis have vibrating brushes underneath and loose magnets on their periphery, causing them to spend more time at locations with more neighbors.” The experimental platform was supplemented by precise computer simulations led by Georgia Tech physics student Shengkai Li, as a way to study aspects of the system inconvenient to study in the lab.

Despite the simplicity of the BOBbots, the researchers discovered that, as the robots move and bump into each other, “compact aggregates form that are capable of collectively clearing debris that is too heavy for one alone to move,” according to Goldman. “While most people build increasingly complex and expensive robots to guarantee coordination, we wanted to see what complex tasks could be accomplished with very simple robots.”

Their work, as reported April 23, 2021 in the journal Science Advances, was inspired by a theoretical model of particles moving around on a chessboard. A theoretical abstraction known as a self-organizing particle system was developed to rigorously study a mathematical model of the BOBbots. Using ideas from probability theory, statistical physics and stochastic algorithms, the researchers were able to prove that the theoretical model undergoes a phase change as the magnetic interactions increase — abruptly changing from dispersed to aggregating in large, compact clusters, similar to phase changes we see in common everyday systems, like water and ice.

“The rigorous analysis not only showed us how to build the BOBbots, but also revealed an inherent robustness of our algorithm that allowed some of the robots to be faulty or unpredictable,” notes Randall, who also serves as a professor of computer science and adjunct professor of mathematics at Georgia Tech.

###

The collaboration is based on experiments and simulations also designed by Bahnisikha Dutta, Ram Avinery and Enes Aydin from Georgia Tech, as well as on theoretical work by Andrea Richa and Joshua Daymude from Arizona State University, and Sarah Cannon from Claremont McKenna College, who is a recent Georgia Tech graduate.

This work is part of a Multidisciplinary University Research Initiative (MURI) funded by the Army Research Office (ARO) to study the foundations of emergent computation and collective intelligence.

Funding: This work was supported by the Department of Defense under MURI award no. W911NF-19-1-0233 and by NSF awards DMS-1803325 (S.C.); CCF-1422603, CCF-1637393, and CCF-1733680 (A.W.R.); CCF-1637031 and CCF-1733812 (D.R. and D.I.G.); and CCF-1526900 (D.R.).

####

About Georgia Institute of Technology
The Georgia Institute of Technology, or Georgia Tech, is a top 10 public research university developing leaders who advance technology and improve the human condition. The Institute offers business, computing, design, engineering, liberal arts, and sciences degrees. Its nearly 40,000 students, representing 50 states and 149 countries, study at the main campus in Atlanta, at campuses in France and China, and through distance and online learning. As a leading technological university, Georgia Tech is an engine of economic development for Georgia, the Southeast, and the nation, conducting more than $1 billion in research annually for government, industry, and society.

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Jess Hunt-Ralston
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@GeorgiaTech

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Polarization-sensitive photodetection using 2D/3D perovskite heterostructure crystal

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Home > Press > Polarization-sensitive photodetection using 2D/3D perovskite heterostructure crystal

(a) Schematic structure of polarized light detector. (b) Photoconductivity parallel and perpendicular to the interface. (c) Photoconductivity anisotropy versus excitation power. (d) Angle-resolved photocurrent as a function of polarization angle measured at 405 nm under zero bias. (e) Experimental polarization ratios of some reported polarized light detectors. (f) Angle-dependent photocurrent of the present device measured at different temperature. CREDIT
@Science China Press
(a) Schematic structure of polarized light detector. (b) Photoconductivity parallel and perpendicular to the interface. (c) Photoconductivity anisotropy versus excitation power. (d) Angle-resolved photocurrent as a function of polarization angle measured at 405 nm under zero bias. (e) Experimental polarization ratios of some reported polarized light detectors. (f) Angle-dependent photocurrent of the present device measured at different temperature. CREDIT
@Science China Press

Abstract:
Polarization-sensitive photodetectors, based on anisotropic semiconductors, have exhibited wide advantages in specialized applications, such as astronomy, remote sensing, and polarization-division multiplexing. For the active layer of polarization-sensitive photodetectors, recent researches focus on two-dimensional (2D) organic-inorganic hybrid perovskites, where inorganic slabs and organic spacers are alternatively arranged in parallel layered structures. Compared with inorganic 2D materials, importantly, the solution accessibility of hybrid perovskites makes it possible to obtain their large crystals at low cost, offering exciting opportunities to incorporate crystal out-of-plane anisotropy for polarization-sensitive photodetection. However, limited by the absorption anisotropy of the material structure, polarization sensitivity of such a device remains low. Thus, a new strategy to design 2D hybrid perovskites with large anisotropy for polarization-sensitive photodetection is urgently needed.

Polarization-sensitive photodetection using 2D/3D perovskite heterostructure crystal


Beijing, China | Posted on May 4th, 2021

Heterostructures provide a clue to address this challenge. On the one hand, construction of heterostructures can improve the optical absorption and free-carrier densities of the composite. On the other hand, the built-in electric field at the heterojunction can spatially separate the photogenerated electron-hole pairs, significantly reducing the recombination rate and further enhancing the sensitivity for polarization-sensitive photodetectors. Therefore, constructing single-crystalline heterostructures of anisotropic 2D hybrid perovskites would realize devices with high polarization sensitivity.

In a new research article published in the Beijing-based National Science Review, scientists at the Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences create a 2D/3D heterostructure crystal, combining the 2D hybrid perovskite with its 3D counterpart; and achieve polarization-sensitive photodetection with record-high performance. Different from the previous work, devices based on the heterostructure crystal deliberately leverage the anisotropy of 2D perovskite and the built-in electric field of heterostructure, permitting the first demonstration of a perovskite heterostructure-based polarization-sensitive photodetector that operates without the need for external energy supply. Notably, the polarization sensitivity of the device surpasses all of the reported perovskite-based devices; and can be competitive with conventional inorganic heterostructure-based photodetectors. Further studies disclose that the built-in electric field formed at the heterojunction can efficiently separate those photogenerated excitons, reducing their recombination rate and therefore enhancing the performance of the resulting polarization-sensitive photodetector.

“High polarization sensitivity is successfully achieved in self-driven polarization-sensitive photodetector based on a single-crystalline 2D/3D hybrid perovskite heterostructure which is grown via a delicate solution method,” the author claims, “This innovative study broadens the choice of materials that can be used for high-performance polarization-sensitive photodetectors, and correspondingly, the design strategies.”

###

This research received funding from the the National Natural Science Foundation of China, the Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS), the Natural Science Foundation of Fujian Province, the Strategic Priority Research Program of the CAS and the Youth Innovation Promotion of CAS.

####

About Science China Press
The National Science Review is the first comprehensive scholarly journal released in English in China that is aimed at linking the country’s rapidly advancing community of scientists with the global frontiers of science and technology. The journal also aims to shine a worldwide spotlight on scientific research advances across China.

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Junhua Luo

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A silver lining for extreme electronics

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MSU researchers developed a process to create more resilient circuitry, which they demonstrated by creating a silver Spartan helmet. The circuit was designed by Jane Manfredi, an assistant professor in the College of Veterinary Medicine. Credit: Acta Materialia Inc./Elsevier
MSU researchers developed a process to create more resilient circuitry, which they demonstrated by creating a silver Spartan helmet. The circuit was designed by Jane Manfredi, an assistant professor in the College of Veterinary Medicine. Credit: Acta Materialia Inc./Elsevier

Abstract:
Tomorrow’s cutting-edge technology will need electronics that can tolerate extreme conditions. That’s why a group of researchers led by Michigan State University’s Jason Nicholas is building stronger circuits today.

A silver lining for extreme electronics


East Lansing, MI | Posted on April 30th, 2021

Nicholas and his team have developed more heat resilient silver circuitry with an assist from nickel. The team described the work, which was funded by the U.S. Department of Energy Solid Oxide Fuel Cell Program, on April 15 in the journal Scripta Materialia.

The types of devices that the MSU team is working to benefit — next-generation fuel cells, high-temperature semiconductors and solid oxide electrolysis cells — could have applications in the auto, energy and aerospace industries.

Although you can’t buy these devices off the shelf now, researchers are currently building them in labs to test in the real world, and even on other planets.

For example, NASA developed a solid oxide electrolysis cell that enabled the Mars 2020 Perseverance Rover to make oxygen from gas in the Martian atmosphere on April 22. NASA hopes this prototype will one day lead to equipment that allows astronauts to create rocket fuel and breathable air while on Mars.

To help such prototypes become commercial products, though, they’ll need to maintain their performance at high temperatures over long periods of time, said Nicholas, an associate professor in the College of Engineering.

He was drawn to this field after years of using solid oxide fuel cells, which work like solid oxide electrolysis cells in reverse. Rather than using energy to create gases or fuel, they create energy from those chemicals.

“Solid oxide fuel cells work with gases at high temperature. We’re able to electrochemically react those gases to get electricity out and that process is a lot more efficient than exploding fuel like an internal combustion engine does,” said Nicholas, who leads a lab in the Chemical Engineering and Materials Science Department.

But even without explosions, the fuel cell needs to withstand intense working conditions.

“These devices commonly operate around 700 to 800 degrees Celsius, and they have to do it for a long time — 40,000 hours over their lifetime,” Nicholas said. For comparison, that’s approximately 1,300 to 1,400 degrees Fahrenheit, or about double the temperature of a commercial pizza oven.

“And over that lifetime, you’re thermally cycling it,” Nicholas said. “You’re cooling it down and heating it back up. It’s a very extreme environment. You can have circuit leads pop off.”

Thus, one of the hurdles facing this advanced technology is rather rudimentary: The conductive circuitry, often made from silver, needs to stick better to the underlying ceramic components.

The secret to improving the adhesion, the researchers found, was to add an intermediate layer of porous nickel between the silver and the ceramic.

By performing experiments and computer simulations of how the materials interact, the team optimized how it deposited the nickel on the ceramic. And to create the thin, porous nickel layers on the ceramic in a pattern or design of their choosing, the researchers turned to screen printing.

“It’s the same screen printing that’s used to make T-shirts,” Nicholas said. “We’re just screen-printing electronics instead of shirts. It’s a very manufacturing-friendly technique.”

Once the nickel is in place, the team puts it in contact with silver that’s melted at a temperature of about 1,000 degrees Celsius. The nickel not only withstands that heat — its melting point is 1,455 degrees Celsius — but it also distributes the liquified silver uniformly over its fine features using what’s called capillary action.

“It’s almost like a tree,” Nicholas said. “A tree gets water up to its branches via capillary action. The nickel is wicking up the molten silver via the same mechanism.”

Once the silver cools and solidifies, the nickel keeps it locked onto the ceramic, even in the 700 to 800 degree Celsius heat it would face inside a solid oxide fuel cell or a solid oxide electrolysis cell. And this approach also has the potential to help other technologies, where electronics can run hot.

“There are a wide variety of electronic applications that require circuit boards that can withstand high temperatures or high power,” said Jon Debling, a technology manager with MSU Technologies, Michigan State’s tech transfer and commercialization office. “These include existing applications in automotive, aerospace, industrial and military markets, but also newer ones such as solar cells and solid oxide fuel cells.”

As a technology manager, Debling works to commercialize Spartan innovations and he’s working to help patent this process for creating tougher electronics.

“This technology is a significant improvement — in cost and temperature stability — over existing paste and vapor deposition technologies,” he said.

For his part, Nicholas remains most interested in those cutting-edge applications on the horizon, things like solid oxide fuel cells and solid oxide electrolysis cells.

“We’re working to improve their reliability here on Earth — and on Mars,” Nicholas said.

###

Also contributing to the project were Spartan engineering researchers Assistant Professor Hui-Chia Yu, Professor Timothy Hogan and Professor Thomas Bieler. Graduate student researchers on the project included Genzhi Hu, Quan Zhou, Aiswarya Bhatlawande, Jiyun Park, Robert Termuhlen and Yuxi Ma (Zhou, Bhatlawande and Ma have since graduated).

One of the project’s coleaders at Brown University, Professor Yue Qi, also has ties to MSU. She served as faculty and the inaugural associate dean of inclusion and diversity in the College of Engineering through 2020.

####

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Caroline Brooks

@MSUnews

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